A5083583513- Inorganic Chemistry and Materials
- Organometallic Complex Synthesis and Catalysis
- Nanocluster Synthesis and Applications
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Properties of Aromatic Compounds
- Synthesis and characterization of novel inorganic/organometallic compounds
- Free Radicals and Antioxidants
- Advanced Chemical Physics Studies
- Inorganic Fluorides and Related Compounds
- Electrochemical Analysis and Applications
- Electrocatalysts for Energy Conversion
- Polyoxometalates: Synthesis and Applications
- Iron-based superconductors research
- Molecular Junctions and Nanostructures
- Metal complexes synthesis and properties
- Synthesis and Biological Evaluation
- MXene and MAX Phase Materials
- Organic Light-Emitting Diodes Research
- Arsenic contamination and mitigation
- Metalloenzymes and iron-sulfur proteins
- Cerebral Palsy and Movement Disorders
- Fuel Cells and Related Materials
- Analytical Methods in Pharmaceuticals
Universidad Central de Chile
2023-2024
University of the Americas
2023
Universidad de Aconcagua
2022
Universidad Pedro de Valdivia
2020-2021
Universidad Bernardo O'Higgins
2011-2020
Universidad Andrés Bello
2008-2012
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment HepG2 cells for 24 h with 2’-hydroxychalcones resulted in apoptosis induction dose-dependent inhibition cell proliferation. The calculated reactivity indexes adiabatic electron affinities using DFT method including solvent effects, suggest a structure-activity relationship Chalcones structure cells. absence methoxy substituents B ring 2’-hydroxychalcones, showed...
Abstract The use of deep eutectic solvent (DES)/water mixtures were explored for the selective enzymatic synthesis α‐monobenzoate glycerol (α‐MBG) from and benzoic acid as substrates. Experiments performed with four DES, three them containing choline chloride (ChCl), combined urea (URA), (GLY), ethylene glycol (ETA) (in all cases ChCl/HBD 1:2 mol ratio), another one formed methylammonium (MA/GLY 1:3 ratio). best conversions (99 %) achieved immobilized lipase B Candida antarctica (CAL‐B) when...
The chiral-induced spin selectivity effect (CISS) is a breakthrough phenomenon that has revolutionized the field of electrocatalysis. We report first study on electron spin-dependent electrocatalysis for oxygen reduction reaction, ORR, using iron phthalocyanine, FePc, well-known molecular catalyst this reaction. FePc complex belongs to non-precious catalysts group, whose active site, FeN4, emulates catalytic centers biocatalysts such as Cytochrome c. This presents an experimental platform...
Success in cancer chemotherapy is based on the selectivity of some drugs to induce tumor cell death without affecting normal cells. In that respect, metal-based appear be promising development efficient anticancer agents. Here, we evaluate efficacy anionic hexa-iodo rhenium selenide cluster, Re6Se8I63−, which was predicted years ago luminescent, selectively increase death, leaving non-tumoral cells unaffected. Thus, here explore its intracellular localization by taking advantage revealed...
Objective: To determine the association between academic performance and eating behavior in university students Chile.Methods: A total of 680 college students, 409 (60%) women 271 (40%) men, were randomly recruited mean age entire sample was 26. The Three-Factor Eating Questionnaire (TFEQ), which evaluates 3 dimensions behavior—cognitive restriction (limiting own intake), uncontrolled (inclination to eat), emotional (control food intake context negative emotions)—was used. Academic measured...
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers worldwide. Chemoprevention HCC can be achieved through use natural or synthetic compounds that reverse, suppress prevent development cancer progression. In this study, we investigated antiproliferative effects and mechanism action two compounds, 2,3,4′-trimethoxy-2′-hydroxy-chalcone (CH1) 3′-bromo-3,4-dimethoxy-chalcone (CH2), over human hepatoma cells (HepG2 Huh-7) cultured mouse hepatocytes (HepM). Cytotoxic were...
Abstract The chiral‐induced spin selectivity effect (CISS) is a breakthrough phenomenon that has revolutionized the field of electrocatalysis. We report first study on electron spin‐dependent electrocatalysis for oxygen reduction reaction, ORR, using iron phthalocyanine, FePc, well‐known molecular catalyst this reaction. FePc complex belongs to non‐precious catalysts group, whose active site, FeN4, emulates catalytic centers biocatalysts such as Cytochrome c. This presents an experimental...
A chronotype is an individual trait that determines circadian rhythm (dark/light cycle) characteristics, associated with bedtime, waking, and other daily activities. classified as morning, intermediate, evening. The objective to associate chronotypes academic performance in university students. cross-sectional study was performed evaluate the of students (n = 703) by Horne-Ostberg questionnaire performance. group higher GPAs had scores (p 0.002). Morning intermediate exhibited better...
The reactions of the previously reported cluster complexes [Re6(μ3-Se)8(PEt3)5I]I, trans-[Re6(μ3-Se)8(PEt3)4I2], and cis-[Re6(μ3-Se)8(PEt3)4I2] with [Re6(μ3-Se)8]2+ core CO in presence AgSbF6 afforded corresponding carbonyls [Re6(μ3-Se)8(PEt3)5(CO)][SbF6]2 (1), trans-[Re6(μ3-Se)8(PEt3)4(CO)2][SbF6]2 (2), cis-[Re6(μ3-Se)8(PEt3)4(CO)2][SbF6]2 (3). Infrared spectroscopy indicated weakening bond CO, suggesting existence backbonding between ligand(s). Electrochemical studies focusing on...
Chagas disease (CD) is one of the most important neglected tropical disorders, being a major health concern in Latin America.
We study the relativistic effects on aromaticity of six hexahalogenated compounds C<sub>6</sub>X<sub>6</sub>,<italic>via</italic>a magnetically induced current density method.
The cluster Re6Se8I63− has been shown to induce preferential cell death of a hepatic carcinoma line, thus becoming promising anti-cancer drug. Whether this induces acute hemolysis or if it interacts with albumin remains unclear. effect exposure human red blood cells different concentrations the and without is described. Red from healthy donors were isolated, diluted at 1% hematocrit exposed (25–150 µM) 37 °C, under agitation. Hemolysis morphology analyzed 1 24 h. potential protection 0.1%...
In this study we report about the aromaticity of prototypical [(HtAc)3(μ2-H)6], [(HtTh)3(μ2-H)6]+, and [(HtPa)3(μ2-H)6] clusters via two magnetic criteria: nucleus-independent chemical shifts (NICS) magnetically induced current density. All-electron density functional theory calculations were carried out using two-component zeroth-order regular approach four-component Dirac-Coulomb Hamiltonian, including scalar spin-orbit relativistic effects. Four-component maps integration ring-current...
The binding of ethambutol to the C‐terminal domain arabinosyltransferase from Mycobacterium tuberculosis was studied. analysis performed using an in silico approach order find out, by docking calculations and energy descriptors, conformer Ethambutol that forms most stable complex with arabinosyltransferase. shows location coincides cocrystallization ligand position amino acid residues ASH1051, ASN740, ASP1052, ARG1055 should be critical EmbC.
Abstract This work reports the magnetic index of aromaticity cyclophosphazene (‐PNH) and their halogenated cyclic derivatives: ‐PNF, ‐PNCl, ‐PNBr, ‐PNI, ‐PNAt ‐PNTs. index, also known as ring‐current strength, is calculated by numerical integration magnetically‐induced current density vector field which generated a perturbing external field. Due to presence heavy atoms in ‐PNX, important relativistic were expected. Accordingly, all‐electron functional theory (DFT) calculations carried out...