A5064208853- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Neural dynamics and brain function
Norwegian University of Science and Technology
2021-2022
University of Edinburgh
2022
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at time in freely moving mice. With weight below 3 g and highly flexible connection cable, MINI2P allowed stable with no impediment behavior variety assays compared to untethered, unimplanted animals. The improved cell yield was achieved through optical system design featuring an enlarged field view (FOV) microtunable lens increased z-scanning range speed...
This study outlines two novel protocols for examining context specific recall in animals prior to embarking on neurobiological studies. The approach is distinct from and contrasts with studies investigating associative familiarity that depend upon procedural variations of the widely used object recognition task. It uses an event arena which are trained across numerous sessions search for, find dig up reward sandwells during sample choice trials - a prominent spatial rodent. could be laid out...
Summary We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at time in freely moving mice. With weight below 3g and highly flexible connection cable, MINI2P allowed to proceed with no impediment behavior half-hour free-foraging trials compared untethered, unimplanted animals. The improved cell yield was achieved through new optical system design featuring an enlarged field view (FOV) micro-tunable lens...