A5071649962- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- HIV-related health complications and treatments
- Renal Transplantation Outcomes and Treatments
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Muscle activation and electromyography studies
- Bacterial biofilms and quorum sensing
- Pharmacological Effects and Toxicity Studies
- Neurological Complications and Syndromes
- Heart Rate Variability and Autonomic Control
- COVID-19 epidemiological studies
- COVID-19 and healthcare impacts
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Advanced Sensor and Energy Harvesting Materials
University of Alberta
2023-2024
Diabetes Canada
2023-2024
22q11 Ireland
2024
Alberta Hospital Edmonton
2023
University of Exeter
2020-2022
Phillips Exeter Academy
2022
Research Network (United States)
2020
The Ohio State University Wexner Medical Center
2018
Environmental and intracellular stresses can perturb protein homeostasis trigger the formation accumulation of aggregates. It has been recently suggested that level aggregates accumulated in bacteria correlates with frequency persister viable but nonculturable cells transiently survive treatment multiple antibiotics. However, these findings have often obtained employing fluorescent reporter strains. This enforced heterologous expression facilitates visualization could also Using...
C-peptide declines in type 1 diabetes, although many long-duration patients retain low, but detectable levels. Histological analyses confirm that β-cells can remain following diabetes onset. We explored the trends observed decline UK Genetic Resource Investigating Diabetes (UK GRID) cohort (N = 4,079), with β-cell loss pancreas donors from network for Pancreatic Organ (nPOD) biobank and Exeter Archival Biobank (EADB) (combined N 235), stratified by recently reported age at diagnosis...
Abstract Aims Misclassification of diabetes is common due to an overlap in the clinical features type 1 and 2 diabetes. Combined diagnostic models incorporating biomarker information have recently been developed that can aid classification, but they not validated using pancreatic pathology. We evaluated a model against histologically defined Methods classified cases from Network for Pancreatic Organ donors with Diabetes (nPOD) biobank as ( n = 111) or non‐type 42) histopathology. Type was by...
Human islets from deceased organ donors have made important contributions to our understanding of pancreatic endocrine function and continue be an resource for research studies aimed at understanding, treating, preventing diabetes. Understanding the impacts isolation culture upon yield human is planning islet distribution distant laboratories. Here, we examine cell outcomes Alberta Diabetes Institute (ADI) IsletCore (n = 197). Research-focused isolations typically a lower equivalents (IEQ),...
Recent joint American Diabetes Association and European for the Study of guidelines recommend routine islet autoantibody testing in all adults newly diagnosed with type 1 diabetes. We aimed to assess impact this population.We prospectively assessed relationship between status (GADA, IA-2A, ZNT8A), clinical genetic characteristics, progression (annual change urine C-peptide-to-creatinine ratio [UCPCR]) 722 (≥18 years old at diagnosis) clinically diabetes duration <12 months. also evaluated...
Abstract This study describes risk factors associated with mortality among COVID-19 cases reported in the WHO African region between 21 March and 31 October 2020. Average hazard ratios of death were calculated using weighted Cox regression as well median time to for key factors. We included 46 870 confirmed by eight Member States region. The overall incidence was 20.06 per 100 000, a total 803 deaths observation 3 959 874 person-days. Male sex (aHR 1.54 (95% CI 1.31–1.81); P < 0.001),...
Abstract Context High-residual C-peptide in longer-duration type 1 diabetes (T1D) is associated with fewer hypoglycemic events and reduced glycemic variability. Little known about the impact of close to diagnosis. Objective Using continuous glucose monitoring (CGM) data from a study newly diagnosed adults T1D, we aimed explore if variation diagnosis influenced variability risk hypoglycemia. Methods We studied T1D who wore Dexcom G4 CGM for 7 days as part Exercise Type Diabetes (EXTOD) study....
An increase in recording interval continuous glucose monitors results the identification of fewer hypoglycaemic episodes but interpolation can help to identify some these missed
Introduction People living with diabetes in low-resource settings may be at increased hypoglycemia risk due to food insecurity and limited access glucose monitoring. We aimed assess associated sulphonylurea (SU) insulin therapy people type 2 a sub-Saharan African setting. Research design methods This study was conducted the outpatients’ clinics of two hospitals (one rural one urban) Uganda. used blinded continuous monitoring (CGM) self-report compare rates duration 179 patients treated...
Abstract Aims/hypothesis TCF7L2 variants are the strongest genetic risk factor for type 2 diabetes. In individuals with 1 diabetes, these associated a higher C-peptide AUC, lower glucose AUC during an OGTT, single autoantibody positivity near diagnosis, particularly in older than 12 years of age, and frequency diabetes-associated HLA genotypes. Based on initial observations from clinical cohorts, we tested hypothesis that diabetes-predisposing percentage residual insulin-containing cells...
<p> </p> <p><strong>Objective</strong></p> <p>Recent joint American and European diabetes association guidelines recommend routine islet autoantibody testing in all adults newly diagnosed with type 1 diabetes. We aimed to assess the impact of this population.</p> <p><strong>Research Design Methods</strong></p> <p>We prospectively assessed characteristics progression (annual change Urine C-peptide Creatinine Ratio...
The future of islet transplantation (ITx) is rapidly moving towards stem-cell based therapies, which have led to short term insulin independence when delivered into the hepatic portal vein. It likely that multiple infusions will be needed maintain long term. We examined effects sequential ITx on pressures and if features transplanted preparation influence acute changes in pressure. include data from adults undergoing intraportal at University Alberta Hospital between May 1999 April 2023....
Abstract Human islets from deceased organ donors have made important contributions to our understanding of pancreatic endocrine function and continue be an resource for research studies aimed at understanding, treating, preventing diabetes. Understanding the impacts isolation culture upon yield human is planning islet distribution distant laboratories. Here we examine cell outcomes Alberta Diabetes Institute (ADI) IsletCore (n=197). Research-focused isolations typically a lower equivalents...
Islet transplantation (ITx) is an established treatment for recurrent, severe hypoglycemia in type 1 diabetes, however, requires lifelong immunosuppression (IS) which can be nephrotoxic. We conducted a risk regression to identify factors associated with progression Stage 3 CKD (S3CKD) or worse post-ITx. used data from adults undergoing ITx alone at the University of Alberta Hospital between March 11 1999 and Oct 2019 &gt;1 year follow up. IS included tacrolimus sirolimus/mycophenolate....
Islet transplantation (ITx) is an established treatment for recurrent, severe hypoglycemia in type 1 diabetes, but requires lifelong immunosuppression (IS) which can be nephrotoxic. We examined long term changes renal function after ITx, through estimated GFR (eGFR), a single centre cohort followed up to 20 years. used data from adults undergoing islet kidney or ITx alone (94%) at the University of Alberta Hospital between March 11 1999 and Oct 2019 with &gt;1 year follow up. IS included...
Composite scores using fasting samples have been developed to routinely monitor beta cell mass after islet transplantation in type 1 diabetes (T1D). They may also utility new onset or T1D prevention trials as an alternative mixed meal tolerance tests measuring AUC C-peptide. We examined if a composite score stimulated C-peptide was equivalent estimating and reflected changes over time. BETA-2 (fasting C-peptide, glucose, insulin dose, HbA1c) BETA-2stim (using AUC) were calculated 1312...
Introduction: The BETA-2 score is a clinical composite used to assess graft function after islet transplantation (ITx). This incorporates C-peptide, fasting plasma glucose, hemoglobin A1c, and insulin requirements. However, C-peptide undergoes renal clearance may accumulate in people with impairment. We sought examine the effect of impairment on ITx recipients. Methods: Cross-sectional study recipients at University Alberta. Most recent scores (pre-graft failure), its components (insulin...