Abstract The objective of the present investigation was to elucidate time‐dependence phosphate adsorption by calcium carbonate and Ca‐kaolinite suggest a mechanism adsorption. at low concentrations in solution could be described Langmuir isotherms, indicating that monolayer is formed on surface. calculated maximum surface saturation 25µg/g for 187µg/g Ca‐kaolinite. A second‐order kinetic equation developed which considers both change concentration adsorbent during process. rate constant...

Rapamycin has been considered as a potential treatment for osteoarthritis (OA). Drug carriers fabricated from liposomes can prolong the effects of drugs and reduce side drugs. Low-intensity pulsed ultrasound (LIPUS) found to possess anti-OA effects.The anti-osteoarthritic liposome-encapsulated rapamycin (L-rapa) combined with LIPUS were examined by culture normal OA chondrocytes in alginate beads further validated prone Dunkin-Hartley guinea pigs.L-rapa largely up-regulated aggrecan type II...

Abstract Barrier membranes are employed clinically to deflect the growth of gingival tissues away from root surface. They provide an isolated space over regions with defective that allow relatively slow growing periodontal ligament fibroblasts be repopulated onto Several makes bioabsorbable now commercially available. In this study, we have chitosan as barrier membrane material and evaluated it for a guided tissue regeneration application. Three types membranes: Chi‐NaOH, Chi‐Na 5 P 3 O 10 ,...

Astaxanthin (Asta) has been demonstrated to possess anti-inflammatory, antitumor, and free radical-clearing activities. However, the poor stability low water solubility of Asta hamper its bioavailability. The objectives this study were fabricate Asta-loaded liposomes (Asta-lipo) investigate therapeutic effects Asta-lipo on alcoholic liver fibrosis in mice. mice administered with or alone prior a 3-week dose containing 30% alcohol without feeding second alcohol. prepared 225.0 ± 58.3 nm...

Lung cancer is one of the most clinically challenging malignant diseases worldwide. Sinulariolide (SNL), extracted from farmed coral species Sinularia flexibilis, has been used for suppressing cells. For developing anticancer therapeutic agents, we aimed to find an alternative non-small cell lung treatment by using SNL as target drug. We investigated bioactivity on A549 cells conjugating with hyaluronan nanoparticles form HA/SNL aggregates a high-voltage electrostatic field system. was toxic...

Astaxanthin (Asta), a xanthophyll carotenoid, has been reported to be strong antioxidative agent and anti-inflammatory, antitumor free radical-scavenging activities. However, inadequate stability water solubility results in its low bioavailability. This study incorporated Asta into hydrophilic hyaluronan nanoparticles (HAn) produce Asta-HAn aggregates (AHAna) using an electrostatic field system investigated the restorative effects of AHAna on retrorsine-CCl₄-induced liver fibrosis rats vivo....

Distal clavicular fractures are less common than involving the middle third of clavicle. For Neer type IIb distal unstable associated with disruption coracoclavicular ligament, surgical treatment is indicated because high risk nonunion. Various methods can be found in literature, but no gold standard has been established. We treated 29 consecutive adult patients fracture single suture fixation by using Mersilene tape (Ethicon, Somerville, New Jersey) and without repair torn ligament or...

The stimulatory effects of liposomal propranolol (PRP) on proliferation and differentiation human osteoblastic cells suggested that the prepared liposomes-encapsulated PRP exerts anabolic bone in vivo. Iontophoresis provides merits such as sustained release drugs circumvention first pass metabolism. This study further investigated evaluated anti-osteoporotic ovariectomized (OVX) rats via iontophoresis. Rats subjected to OVX were administered with pure or iontophoresis subcutaneous injection...

Abstract Background Low-intensity pulsed ultrasound (LIPUS) regiment has been used to treat fractures with non-union and promote bone union in general. The effect of LIPUS on articular cartilage metabolism characterized. Yet, the repair injury remains unclear vivo. Methods We designed a study investigate repairing rabbit severe model. Eighteen rabbits were divided into three groups: Sham-operated group, operated group without-LIPUS-treatment, with-LIPUS-treatment (a daily 20-minute treatment...

The effects against tumors exerted by marine active compounds have been highlighted and investigated. Polymeric nanoparticles made from biodegradable biocompatible molecules such as hyaluronan (HA) chitosan (CHI) are able to aggregate the enhance their activities tumor cells reduce toxicity on normal cells. Here, we extensively examined antitumor mechanisms of HA/CHI nanoparticles-aggregated heteronemin (HET) extracted sponge Hippospongia sp. half-maximal inhibitory concentration (IC50) pure...

Abstract A simple and in situ method, by using a high‐voltage electrostatic system, for the fabrication of chitosan microspheres (in form isolatable microgels) an extrusion process, exhibiting variable sizes different membrane structures, was presented. The exhibited good sphericity were range 185.8 ± 13.8 to 380.9 11.5 μm diameter. There two significant factors, pump flow rate field strength, that affected microsphere size. size decreased when increased from 0.1 0.4 mL/h. Also, strength 5.5...

Abstract Guided tissue regeneration (GTR) membranes with bioabsorbable characteristics have been employed, in recent years, for periodontal procedures to deflect the growth of gingival tissues away from root surface. They provide an isolated space over regions defective and allow relatively slow growing ligament fibroblasts be repopulated In this study, we employed chitosan tricalcium phosphate (β‐TCP) as viable membrane materials evaluated their roles GTR applications. Three types...

Purpose This study aimed to develop a quantitative dry cupping system that can monitor negative pressure attenuation and soft tissue pull-up during quantify compliance. Methods Baseball players with myofascial pain syndrome were recruited validate the benefits of therapy. Nine 40 baseball on same team diagnosed trapezius syndrome; another nine from as controls. All participants received 400 mmHg for 15 minutes each time, twice week, 4 weeks. Subjective perception was investigated using upper...

Abstract Chitosan membranes were first prepared by a thermally induced phase separation method and then alginate was coated on one side of the modified dialysis apparatus to prepare alginate/chitosan (A/C membranes). Electron spectroscopy for chemical analysis (ESCA), scanning electron microscope, contact angle measurements conducted evaluate surface characteristics. The mechanical strength, degradation behavior, cell adhesion test performed feasibility using A/C membrane in guided tissue...

The aim of this study was to investigate the ability nano‐sized collagen I molecules (nanoparticles or nanofibrils) and a 5‐azacytidine (5‐aza) treatment enhance differentiation rat mesenchymal stem cells (MSCs) toward cardiomyogenic phenotype in vitro . Second passaged MSCs were cocultured with for 24 h then treated 10 μ M 5‐aza h. results demonstrated that size increased significantly acquired flattened, triangular‐shaped morphology after 5‐aza. are connecting adjoining by forming...

Abstract This study related to the preparation of chitosan microspheres by means reacting with β‐tricalcium phosphate (β‐TCP) and glutaraldehyde crosslinking reaction in oil phase, followed de‐oil purification processes get product. Three cement composites, Pure P, C1P1, C2P1, were prepared polymerization poly(methyl methacrylate) (PMMA) bone presence 0, 50, 66.7% chitosan/β‐TCP microspheres, respectively. The result revealed obtained was size range 50–150 μm. composites decreased ultimate...

Abstract Chitosan was first converted into micro‐droplets by using a high voltage electrostatic field system. The droplets were then dropped series of Na 5 P 3 O 10 /NaOH solution mixtures with volume ratio 17:3, 19:1, 1:0 (pure aqueous ) or 0:1 NaOH) in order to fabricate chitosan microspheres different membrane structures. exhibit distinct chemical and physical properties, including release behaviors encapsulated drugs. These prepared this method exhibited good sphericity within the range...