Pei‐Leun Kang

ORCID: 0000-0001-8970-3535
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About
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Research Areas
  • Congenital Heart Disease Studies
  • Tissue Engineering and Regenerative Medicine
  • Advanced Sensor and Energy Harvesting Materials
  • MXene and MAX Phase Materials
  • Pulmonary Hypertension Research and Treatments
  • Dialysis and Renal Disease Management
  • Periodontal Regeneration and Treatments
  • Electrospun Nanofibers in Biomedical Applications
  • Anesthesia and Neurotoxicity Research
  • Cardiovascular Conditions and Treatments
  • Cardiac Ischemia and Reperfusion
  • Neuroscience and Neural Engineering
  • Aortic Disease and Treatment Approaches
  • Tracheal and airway disorders
  • Hemostasis and retained surgical items
  • Cardiac Valve Diseases and Treatments
  • Surgical Sutures and Adhesives
  • Nanowire Synthesis and Applications
  • Cardiac and Coronary Surgery Techniques
  • Cardiac Structural Anomalies and Repair
  • Vascular Anomalies and Treatments
  • Coronary Artery Anomalies
  • Burn Injury Management and Outcomes
  • Nanoplatforms for cancer theranostics
  • Boron and Carbon Nanomaterials Research

Kaohsiung Veterans General Hospital
2007-2022

National Taiwan University
2011-2013

National University of Malaysia
2013

I-Shou University
2009

National Yang Ming Chiao Tung University
2007

Chang Gung University
2006

Taipei Veterans General Hospital
1992

Background and objectives: Ischaemic preconditioning is commonly regarded as one of the most powerful protective mechanisms against a subsequent lethal ischaemic injury during coronary artery bypass graft surgery but not practiced routinely. Experimentally, isoflurane, used volatile anaesthetic agent, provides myocardial protection through signal transduction cascade that remarkably similar to pathways identified in preconditioning. The aim our study was investigate whether pre-ischaemic...

10.1017/s0265021506000354 article EN European Journal of Anaesthesiology 2006-03-01

Pulmonary artery aneurysm is a rare lesion of the thoracic cavity. Different etiologies have been reviewed, but idiopathic lesions without other symptoms are seldom reported. Usually, surgical interventions suggested, long-term outcomes not well established. Here, we report 24-year-old man with main pulmonary who successfully underwent aneurysmectomy and polytetrafluoroethylene vascular graft replacement. The postoperative course was uneventful, following image study revealed normal size...

10.1016/s1726-4901(08)70038-8 article EN publisher-specific-oa Journal of the Chinese Medical Association 2007-10-01

The aim of this study was to investigate the ability nano‐sized collagen I molecules (nanoparticles or nanofibrils) and a 5‐azacytidine (5‐aza) treatment enhance differentiation rat mesenchymal stem cells (MSCs) toward cardiomyogenic phenotype in vitro . Second passaged MSCs were cocultured with for 24 h then treated 10 μ M 5‐aza h. results demonstrated that size increased significantly acquired flattened, triangular‐shaped morphology after 5‐aza. are connecting adjoining by forming...

10.1002/jbm.a.34589 article EN Journal of Biomedical Materials Research Part A 2013-03-05

The aim of this study was to investigate the changes regional tissue Doppler velocity after volume removal following regular hemodialysis (HD) in uremic patients. Is really preload-independent?Diastolic dysfunction divided into four stages: normal pattern, abnormal relaxation pseudonormalization and restrictive pattern. Pulse wave color echocardiography were important diagnostic tools for these forms diastolic dysfunction. However, they preload-dependent sometimes there confusion between...

10.1159/000099652 article EN Cardiology 2007-01-01

The aim of this article is to introduce a new technique, named the "double balloon occlusion technique" (DBOT), for salvage acutely thrombosed grafts and demonstrate its safety efficacy.Acute thrombosis recognized as most common factor acute graft failures. A suitably percutaneous technique should be devised remove thrombi safely effectively. Care also taken prevent possible thromboembolic complications during procedures. Mainly composed two balloons, DBOT has been developed meet clinical...

10.1002/ccd.21808 article EN Catheterization and Cardiovascular Interventions 2008-10-27

This study focuses on preparation and valuation of the biodegradable, native, modified gelatin film as screen-printing substrates. Modified was prepared by crosslinking with various agents electrode array designed screen-printing. It observed that swelling ratio C-2, crosslinked glutaraldehyde EDC/NHS (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide) found to be lower (3.98%) than C-1 (crosslinked only glutaraldehyde) (8.77%) C-0 (without crosslinking) (28.15%). The...

10.3390/polym12051186 article EN Polymers 2020-05-22

Advances and improvements in mesenchymal stromal/stem cells (MSCs) cell replacement therapies have been promising approaches to treat diabetes mellitus (DM) since their potent capacities for differentiation into various functional match the demands of tissue repair regeneration. The aim this study is examine effects nano-sized type I collagen molecules combination with nicotinamide (NCT) exendin-4 (EX4) on MSC insulin-secreting vitro evaluate reparative against 2 (T2DM) vivo. Differentiation...

10.1039/c6tb00731g article EN Journal of Materials Chemistry B 2016-01-01

Effective cancer therapy relies on delivering the therapeutic agent precisely to target site improve treatment outcome and minimize side effects. Although surgery, chemotherapy, radiotherapy are standard methods commonly used in clinics, hyperthermia has been developed as a new promising strategy for therapy. In this study, magnetic bioceramic hydroxyapatite (mHAP) nanocrystals have heat mediator intracellular hyperthermia. Hyaluronic acid (HA) modified mHAP synthesized by wet chemical...

10.1166/jbn.2016.2128 article EN Journal of Biomedical Nanotechnology 2015-10-13

Platelet gels (PG), activated by bovine thrombin (BT), have increasingly been used in orthopedic surgery. However, BT may induce immunological reactions and carry potential viral prion risks. To avoid these side effects, derived from human plasma (human thrombin, HT) is becoming the preferred platelet activator to prepare PG. limited experience data on clinical benefits of HT-generated PG (HTPG) surgery reported. Consequently, we designed performed a series studies dogs compare impacts...

10.1080/10731190902742497 article EN Artificial Cells Blood Substitutes and Biotechnology 2009-01-01

Endovascular stent-grafting is an alternative treatment for adult patent ductus arteriosus (PDA), especially in elderly patients. Regarding young adults, endovascular therapy a reasonable choice if the landing zone sufficient. In this study, we report on with PDA successfully treated stent-grafting.

10.6515/acs20151117a article EN PubMed 2016-09-01

The latest European System for Cardiac Operative Risk Evaluation (EuroSCORE) II is a well-accepted risk evaluation system mortality in cardiac surgery Europe.To determine the performance of this new model Taiwanese patients.Between January 2012 and December 2014, 657 patients underwent at our institution. EuroSCORE scores all were determined preoperatively. short-term surgical outcomes 30-day in-hospital evaluated to assess II.Of [192 women (29.22%); age 63.5 ± 12.68 years], rate was 5.48%,...

10.6515/acs.202207_38(4).20220128b article EN PubMed 2022-07-01

Introduction: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by the increased vascular resistance and remodeling of pulmonary arteries. Evidences accumulated inflammatory cells in lung suggested that chronic inflammation might play role PAH. Regenerative cell therapy emerged as potential treatment for PAH through regulating host’s immune response. Hypothesis: The secretome induced pluripotent stem (iPSCs) was investigated their preventive therapeutic effects...

10.1161/circ.132.suppl_3.12041 article EN Circulation 2015-11-10
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