A5082900642- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Neuroscience and Neuropharmacology Research
- Caveolin-1 and cellular processes
- Metabolism, Diabetes, and Cancer
- Traditional Chinese Medicine Studies
- Medical Research and Treatments
- CAR-T cell therapy research
- Aortic aneurysm repair treatments
- Abdominal vascular conditions and treatments
- Marine Sponges and Natural Products
- Sport and Mega-Event Impacts
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Immunotherapy and Biomarkers
- Sirtuins and Resveratrol in Medicine
- Doping in Sports
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Advanced optical system design
- Immune Cell Function and Interaction
Hebei Medical University
2011-2024
Jiamusi University
2024
Third Hospital of Hebei Medical University
2011-2018
Boston Biomedical Research Institute
2017
Hefei University of Technology
2012
University of Strathclyde
2005
Discovery Institute
2005
Abstract Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development diabetic nephropathy (DN). Mitochondrial biosynthesis mediated by coactivator PGC‐1α and its downstream transcription factors NRF1 TFAM may a key target maintaining function. Resveratrol (RESV), natural polyphenolic antioxidant, potent SIRT1 agonist. In this study we established diabetes mouse podocyte exposed high glucose as vivo vitro models investigate...
The Hippo (Hpo) pathway is a novel signaling that controls organ size in Drosophila and mammals deregulated variety of human cancers. It consists set kinases that, through number phosphorylation events, inactivate YAP, transcriptional co-activator cellular proliferation apoptosis. We have identified PTPN14 as YAP-binding protein negatively regulates YAP activity by controlling its localization. Mechanistically, we find the interaction ectopic with can be mediated respective WW PPxY motifs....
N-methyl-D-aspartate-receptors (NMDARs) are ionotropic glutamate receptors that function in synaptic transmission, plasticity and cognition. Malfunction of NMDARs has been implicated a variety nervous system disorders, making them attractive therapeutic targets. Overexpression functional NMDAR non-neuronal cells results cell death by excitotoxicity, hindering the development cell-based assays for drug discovery. Here we report plate-based, high-throughput approach to study function. Our...
Abstract Obesity-induced kidney injury contributes to albuminuria, which is characterized by a progressive decline in renal function leading glomerulosclerosis and fibrosis. Matrix metalloproteinases (MMPs) modulate inflammation fibrosis degrading variety of extracellular matrix regulating the activities effector proteins. Abnormal regulation MMP-12 expression has been implicated abdominal aortic aneurysm, atherosclerosis emphysema, but underlying mechanisms remain unclear. The present study...
Abstract DCBLD2 is a neuropilin‐like transmembrane protein that up‐regulated during arterial remodeling in humans, rats, and mice. Activation of PDGFR‐β via PDGF triggers receptor phosphorylation endocytosis. Subsequent activation downstream signals leads to the stimulation phenotypic conversion VSMCs wall proliferation, which are common pathological changes vascular diseases such as atherosclerosis, hypertension, restenosis after angioplasty. In this study, we hypothesized regulates...
Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and associated with excessive cardiovascular morbidity mortality. The angiotensin converting enzyme inhibitor (ACEI) benazepril has been shown to slow progression renal have beneficial effects in patients a combination disease. Transforming growth factor-β1 (TGF-β1) plays central role pathogenesis DN. Integrin-linked kinase (ILK) can modulate TGF-β1-induced glomerular mesangial cell (GMC) injury, which prominent...
Just-in-time cell supply for cell-based high-throughput screening (HTS) is frequently problematic.In addition to scheduling and logistical issues, quality issues variability due passage effect, cycle, or confluency contribute day-to-day signal in the course of HTS campaigns.Cell division-arrest cryopreservation technologies permit use cells as assay-ready reagents other profiling structure-activity studies.In this report, authors compare division-arrested dividing 2 assay types that are...
Discoidin, CUB, LCCL domain-containing 2 (DCBLD2) is a type I transmembrane protein with similar structure to neuropilin, which acts as co-receptor for certain receptor tyrosine kinases (RTKs). The insulin an RTK and plays critical role in endothelial cell function glycolysis. However, how whether DCBLD2 regulates activity cells poorly understood. Diabetes was induced through treatment of Dcbld2 global-genome knockout mice endothelium-specific streptozotocin. Vascular ultrasound, vascular...
BACKGROUND: Unwanted angiogenesis is involved in the progression of various malignant tumors and cardiovascular diseases, factors that regulate are potential therapeutic targets. We tested hypothesis DCBLD1 (discoidin, CUB, LCCL domain-containing protein 1) a coreceptor VEGFR-2 (vascular endothelial growth factor receptor-2) modulates cells. METHODS: A carotid artery ligation model retinal assay were used to study using globe knockout or cell–specific conditional Dcbld1 mice vivo....
Laser photobiostimulation (LPBS) at the pulsing frequency of 4 Hz applied to low resistance point located base tail rat, (Governing Vessel Meridian 1), produced a hypoalgesic effect, measured by tail-flick and hot-plate techniques. Pre-treatment with dose naloxone (2 mg/kg) did not reverse effect LPBS. High (20 reversed only partially, but significantly, LPBS hot-plate, that technique. These data suggest mechanisms other than endogenous opioids may be involved in LPBS-induced hypoalgesia.
The present study was conducted to determine the effects of 1-O-acetylbritannilactone (ABL), a compound extracted from Inula britannica L., on vascular endothelial growth factor (VEGF) signaling and angiogenesis in cells (ECs). We showed that ABL promotes VEGF-induced cell proliferation, growth, migration, tube formation cultured human ECs. Furthermore, modulatory effect Akt, MAPK p42/44, p38 phosphorylation, as well upstream VEGFR-2 were associated with VEGF-dependent Matrigel vivo. In...
Abstract Objective Unwanted angiogenesis is involved in the progression of various malignant tumors and cardiovascular diseases, factors that regulate are potential therapeutic targets. We tested hypothesis DCBLD1 (Discoidin, CUB, LCCL domain-containing protein 1) a co-receptor VEGFR-2 modulates endothelial cells(ECs). Approach Results A carotid artery ligation model retinal assay were used to study using globe knockout or EC-specific conditional mice vivo . Immunoblotting,...