A5036049489- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Sex work and related issues
- Helicobacter pylori-related gastroenterology studies
- Photoreceptor and optogenetics research
- HIV/AIDS Research and Interventions
- HIV/AIDS Impact and Responses
- Neural dynamics and brain function
- HIV, Drug Use, Sexual Risk
- Transcranial Magnetic Stimulation Studies
- Influenza Virus Research Studies
- Syphilis Diagnosis and Treatment
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Essential Oils and Antimicrobial Activity
- HIV, TB, and STIs Epidemiology
- HIV/AIDS oral health manifestations
- Hemoglobinopathies and Related Disorders
- Gastrointestinal motility and disorders
- Global Maternal and Child Health
- Neuroscience and Neuropharmacology Research
- Nail Diseases and Treatments
- Clostridium difficile and Clostridium perfringens research
- Iron Metabolism and Disorders
Open University of Sri Lanka
2025
MRC Brain Network Dynamics Unit
2018-2023
University of Oxford
2018-2023
University of Sri Jayewardenepura
2021-2022
University of Kelaniya
2019
National AIDS Control Organisation
2016-2018
Colombo North Teaching Hospital
2013
National Hospital of Sri Lanka
2013
Deep brain stimulation (DBS) is known to be an effective treatment for a variety of neurological disorders, including Parkinson's disease and essential tremor (ET). At present, it involves administering train pulses with constant frequency via electrodes implanted into the brain. New 'closed-loop' approaches involve delivering according ongoing symptoms or activity have potential provide improvements in terms efficiency, efficacy reduction side effects. The success closed-loop DBS depends on...
Parkinson’s disease motor symptoms are associated with an increase in subthalamic nucleus beta band oscillatory power. However, these oscillations phasic, and there is a growing body of evidence suggesting that burst duration may be critical importance to symptoms. This makes insights into the dynamics bursting generation valuable, particular refine closed-loop deep brain stimulation disease. In this study, we ask question “Can average reveal how change between ON OFF medication states?”....
Abstract Objective. While brain stimulation therapies such as deep for Parkinson’s disease (PD) can be effective, they have yet to reach their full potential across neurological disorders. Entraining neuronal rhythms using rhythmic has been suggested a new therapeutic mechanism restore neurotypical behaviour in conditions chronic pain, depression, and Alzheimer’s disease. However, theoretical experimental evidence indicate that also entrain at sub- super-harmonics, far from the frequency....
Abstract Essential tremor manifests predominantly as a of the upper limbs. One therapy option is high-frequency deep brain stimulation, which continuously delivers electrical stimulation to ventral intermediate nucleus thalamus at about 130 Hz. Constant can lead side effects, it therefore desirable find ways stimulate less while maintaining clinical efficacy. strategy, phase-locked consists stimulating according phase tremor. To advance methods optimise providing insights into circuits, we...
Dermatophytes, the primary causative agents of superficial cutaneous fungal infections in humans, present a significant therapeutic challenge owing to increasing prevalence recurrent and emergence antifungal resistance. To address this critical gap, study was designed investigate potential 3-benzylideneindolin-2-one against dermatophytes assess its vivo toxicological profile using brine shrimp zebrafish embryo models. The activity evaluated 30 clinical isolates dermatophyte species,...
Deep brain stimulation (DBS) is a well-established treatment option for variety of neurological disorders, including Parkinson’s disease and essential tremor. The symptoms these disorders are known to be associated with pathological synchronous neural activity in the basal ganglia thalamus. It hypothesised that DBS acts desynchronise this activity, leading an overall reduction symptoms. Electrodes multiple independently controllable contacts recent development technology which have potential...
Abstract Objective. Deep brain stimulation is a treatment for medically refractory essential tremor. To improve the therapy, closed-loop approaches are designed to deliver according system’s state, which constantly monitored by recording pathological signal associated with symptoms (e.g. or limb tremor). Since space of possible strategies vast and cannot be fully explored experimentally, how stimulate state should informed modeling. A typical modeling goal design strategy that aims maximally...
Summary Neurological manifestations are reported only occasionally in patients with thalassaemia and given much less prominence than the complications related to anaemia iron overload. White matter changes ( WMC s) on magnetic resonance imaging MRI ) were first two decades ago but significance of these lesions remains unclear. We studied neurological cognitive 82 older thalssaemia [25 Thalassaemia major TM ), 24 intermedia TI 33 haemaglobin E β EBT )] 80 controls, found that headaches more...
Abstract While brain stimulation therapies such as deep for Parkinson’s disease can be effective, they have yet to reach their full potential across neurological disorders. Entraining neuronal rhythms using rhythmic has been suggested a new therapeutic mechanism restore neurotypical behavior in conditions chronic pain, depression, and Alzheimer’s disease. However, theoretical experimental evidence indicate that also entrain at sub- super-harmonics, far from the frequency. Crucially, these...
Abstract Deep brain stimulation (DBS) is known to be an effective treatment for a variety of neurological disorders, including Parkinson’s disease and essential tremor (ET). At present, it involves administering train pulses with constant frequency via electrodes implanted into the brain. New ‘closed-loop’ approaches involve delivering according ongoing symptoms or activity have potential provide improvements in terms efficiency, efficacy reduction side effects. The success closed-loop DBS...
Abstract Parkinson’s disease motor symptoms are associated with an increase in subthalamic nucleus beta band oscillatory power. However, these oscillations phasic, and there is a growing body of evidence suggesting that burst duration may be critical importance to symptoms. This makes insights into the dynamics bursting generation valuable, particular refine closed-loop deep brain stimulation disease. In this study, we ask question “Can average reveal how change between ON OFF medication...
<strong>Introduction: </strong>Factory workers in Export Processing Zones (EPZs) have been identified as a group with vulnerable behaviour for acquiring Sexually Transmitted Infections (STIs) including HIV due to many social and environmental risk factors. This study was done assess the knowledge, attitudes behaviours related STI HIV/AIDS among male female factory Seethawaka EPZ. <strong> </strong> <strong>Method: </strong>A descriptive cross sectional carried out 430 EPZ, using...
Abstract Essential tremor manifests predominantly as a of the upper limbs. One therapy option is high-frequency deep brain stimulation, which continuously delivers electrical stimulation to ventral intermediate nucleus thalamus at about 130 Hz. Investigators have been looking stimulating less, chiefly reduce side effects. strategy, phase-locked consists according phase tremor, once per period. In this study, we aim reproduce dependent effects seen in patient data with biologically inspired...
Australia is a sink for low pathogenicity avian influenza viruses, with isolated circulation occurring on the continent. We report incursion of Eurasian H5 virus into Australia. This benefits surveillance and diagnostic work because risk current absence highly pathogenic A(H5N1).
Sri Lankan Journal of Infectious Diseases (SLJID) is an open access, peer-reviewed, biannual journal published by the Society for Microbiology (SSM). The considers articles from all professional disciplines involved in field infectious diseases. SLJID does not charge any article processing or publication fee. has been since 2011 and included DOAJ 2018.
<strong>Introduction: </strong>Sri Lanka has initiated ART programme in 2004. By the end of 2014 a total 825 patients were receiving care services with 481 at HIV clinic, Colombo. Based on WHO consolidated guidelines published 2013 guideline was updated 2014. It decided to determine response among PLHIV managed according new guideline. The objective study adult attending NSACP. <strong>Methods: </strong>A clinic based prospective carried out main STD/HIV Colombo assess clinical and...
DOI: http://dx.doi.org/10.4038/sljv.v2i1.5399 Sri Lanka Journal of Venereology Vol.2(1) 2009 pp.11-18
Presidential Address 2007 <em>The Sri Lanka Journal of Venereology; Vol.1 No.1; December 2007; Page 5-9</em> <a href="http://dx.doi.org/10.4038/sljv.v1i1.5577">http://dx.doi.org/10.4038/sljv.v1i1.5577</a>
Background The bacterium Treponema pallidum ( T. ) causes syphilis. Penicillin is effective treatment, but azithromycin (a macrolide) a single-dose oral alternative for those with allergy. Unfortunately, macrolide resistance secondary to one of two 23S ribosomal RNA (rRNA) point mutations (A2058G and A2059G) now wide-spread. Molecular strain-typing suggests that epidemics are unlikely the spread single clones. We present typing data from geographically distinct populations: Colombo, Sri...
<strong>Introduction:</strong><strong> </strong>Information regarding sexual health and related issues are of utmost importance to FSW, MSM TGW as their life styles deeply bound with them. However, it is difficult deliver information which mostly goes medical jargon populations lower understanding <strong>Objectives:</strong><strong> </strong>To describe the linguistic patterns terms when communicating sex variations, among Sinhala speaking STD clinic attendees Colombo explore barriers in...
<strong>Sri Lanka has been declared as a country that eliminated mother to child transmission of HIV and syphilis by the World Health Organisation (WHO), Geneva on 13th November 2019.</strong> <br /> National STD AIDS Control Programme (NSACP) Sri <strong>In 1954,</strong> commenced programme for prevention congenital syphilis. 2002</strong>, started HIV. <strong> In 2013,</strong> these two programmes were combined “Elimination (EMTCT) syphilis.” />Overall target was achieve maintain impact...
Abstract Deep brain stimulation (DBS) is a well-established treatment option for variety of neurological disorders, including Parkinson’s disease (PD) and essential tremor (ET). It widely believed that the efficacy, efficiency side-effects can be improved by stimulating ‘closed-loop’, according to symptoms patient. Multi-contact electrodes powered independent current sources are recent development in DBS technology which allow greater precision when targeting one or more pathological regions...
Introduction: Hospital based HIV Rapid Diagnostic Testing (RDT) was introduced in 2018, following programmatic decision. However, being the province with highest prevalence country, number of hospital rapid testing carried out Western not impressive, leading to missed opportunities and late diagnosis. Therefore, RDT re-implemented selected medical wards NHSL. Objective: To assess case detection rate, feasibility challenges services among inpatients Method: A descriptive demonstration study,...
The stomach is considered a sterile organ for long time due to anatomical and physiological features, till the discovery of Helicobacter pylori in 1982, which demolished conception stomach. pathogenicity enhanced by several virulence factors. Initially, with aid culture-based techniques were later followed advanced culture-independent molecular techniques, whereby complexity biodiversity gastric microbiota revealed. Commensals, as well pathogenic microbes have developed mechanisms ensure...