A5048388773- Tissue Engineering and Regenerative Medicine
- Mechanical Circulatory Support Devices
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Organ Transplantation Techniques and Outcomes
- Congenital heart defects research
- Extracellular vesicles in disease
- Infective Endocarditis Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Xenotransplantation and immune response
- Anesthesia and Neurotoxicity Research
- Vascular Procedures and Complications
- Phagocytosis and Immune Regulation
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Urological Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Central Venous Catheters and Hemodialysis
- Cardiac and Coronary Surgery Techniques
- Coronary Artery Anomalies
- Testicular diseases and treatments
University of Pittsburgh Medical Center
2024-2025
Al-Neelain University
2024
Barts Health NHS Trust
2024
Royal London Hospital
2024
Pittsburg State University
2024
Cairo University
2006-2024
Lurie Children's Hospital
2021-2022
Mount Sinai Health System
2021-2022
Icahn School of Medicine at Mount Sinai
2022
Northwestern University
2022
ABSTRACT Background This study evaluates the effects of nighttime procurement and transplantation on outcomes following heart transplantation. Methods The UNOS registry was queried to analyze adult recipients who underwent isolated orthotopic between January 1, 2010, September 30, 2022. cohort stratified into daytime (4 am–8 pm) (8 pm–4 am) transplant groups. primary outcome 1‐year survival. Propensity score‐matching performed. Risk adjustment performed using multivariable Cox regression....
Background Perioperative cardiac xenograft dysfunction (PCXD) describes a rapidly developing loss of function after xenotransplantation. PCXD occurs despite genetic modifications to increase compatibility the heart. We report on incidence using static preservation in ice slush following crystalloid or blood-based cardioplegia versus continuous cold perfusion with XVIVO © heart solution (XHS) based cardioplegia. Methods Baboons were weight matched genetically engineered swine donors....
With encouraging early experience, ex vivo machine perfusion (MP) systems are increasingly employed in heart transplantation. In this study, utilizing a national registry database, 2 separate analyses were performed to evaluate the effects of MP on graft preservation time (total n = 22,794; 308 with MP) and donor age 22,581; 95 donation after brain death (DBD) The cohort was stratified based total (<4 ≥4 hours) (<45 ≥45 years). During study period, use isolated DBD transplantation...
ObjectivesTo evaluate the clinical outcomes and perioperative complications associated with complete percutaneous decannulation of femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) MANTA closure device.MethodsThis is a retrospective analysis single surgeon consecutive series 14 patients at center who underwent from VA-ECMO, 10 whom method cannula removal.ResultsAfter mean duration VA-ECMO support 7.4 ± 3.8 days, all patients, arterial cannulas ranging in size 17 to 21 Fr,...
Successful cell therapy requires cells to resist the hostile ischemic myocardium, be retained continue secreting cardioprotective growth factors/exosomes, and immunological host responses. Clinically relevant stem/progenitor in a rodent model of acute myocardial infarction (MI) demonstrated that neonatal cardiac mesenchymal stromal (nMSCs) provide most robust functional recovery. Transplanted nMSCs significantly increased number tissue reparative macrophages regulatory T-cells decreased...
BACKGROUND AND OBJECTIVES: Many patients with relapsed metastatic breast cancer are pre-treated taxanes and anthracyclines, which usually given in the neoadjuvant/adjuvant setting or as first-line treatment for disease. The primary objective of this study was to determine overall response rate combination gemcitabine cisplatin locally advanced who had after receiving one adjuvant/neoadjuvant chemotherapy regimen containing an anthracycline with/without a taxane. secondary endpoints included...
Stem cell-based therapies have shown promise in adults with ischemic cardiomyopathy and children congenital heart diseases, especially those without available therapeutic options. Human neonatal mesenchymal stem cells (nMSCs) greater regenerative potential than adult cells.To describe our experience a novel catheter system for transcoronary delivery of (CIRCULATE catheter) the intra-coronary nMSCs swine acute myocardial infarct model.A newly developed several unique features, including an...
Central MessageWe report a safe and efficient technique for arterial ECMO cannula exchange in an awake patient that can be performed at the bedside.See Commentaries on pages 86, 88, 90. We bedside. See Although uncommon, fracture of extracorporeal membrane oxygenator (ECMO) with consequent bleeding requires immediate management. describe employed bedside without use general anesthesia or surgical incisions venoarterial peripheral exchange. A 54-year-old man presented cardiogenic shock due to...
<h3>Background</h3> Monogenic diabetes is a rare form of heterogenous disorders resulting from mutations or defects in single gene chromosomal locus with more than 40 subtypes identified to date. Clinical characterization includes early-onset such as neonatal diabetes, maturity-onset the young (MODY), associated extra-pancreatic features, and monogenic insulin resistance (IR) syndromes. It may be inherited dominant, recessive, non-Mendelian trait present spontaneous case due de novo...
Background and objective Cryptorchidism, or undescended testes (UDT), refers to the failure of one both testicles descend their natural position in scrotum newborn males. The association gestational diabetes with cryptorchidism has not been studied sufficiently. Hence, this study aimed analyze between maternal other associated anomalies among Jordanian male children. Methods We conducted a retrospective involving women cryptorchid offspring over 10-year period, January 2010 December 2019....
The criteria for evaluating donations after circulatory death (DCD) heart allografts, particularly donor cardiopulmonary resuscitation (CPR) status, remains underexplored. This study evaluates the impact of CPR on post-transplant outcomes in DCD transplants.
The United Network for Organ Sharing (UNOS) 2018 heart allocation policy prioritizes patients receiving temporary mechanical circulatory support (tMCS) given the high waitlist mortality rate of this group. This study evaluates national trends and outcomes tMCS under UNOS policy. Adult waitlisted isolated transplantation were included using database. prevalence tMCS, 90 day mortality, incidence transplantation, posttransplant 1 year analyzed. A total 27,343 during period (pre-policy change:...
This is a report of very rare case marginal zone lymphoma in 15-years old male with Ataxia Telangiectasia. Besides being diagnosis within the pediatric age group, this exhibited true challenge not only from diagnostic point view but also regarding management plans. Marginal an indolent disease which transformation extremely particularly subtype. However, there isn't enough data sitting immunodeficiency conditions had been published so far. The described here showed some features pointing to...
Left ventricular assist devices can extend life for select patients with advanced heart failure. However, adverse events, including outflow graft obstruction, may occur over time. Outflow obstruction is generally insidious in onset and result low LVAD flows symptoms of In this report, we describe a patient who presented acute decompensation requiring temporary mechanical support due to development extrinsic compression the after HeartMate 3 implantation. The acuity severity case demonstrate...
Fat embolism occurs in all patients with long bone fractures and intra-medullary reaming of but is usually asymptomatic. A few will have pulmonary, cerebral dermal dysfunction; this triad called fat syndrome (FES). We report a case FES developed after intramedullary nailing both femurs that was successfully managed our surgical intensive care unit (SICU).