The potential of the cluster regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9)-based therapeutic genome editing is severely hampered by difficulties in precise regulation vivo activity CRISPR-Cas9 system. Herein, sono-controllable and reactive oxygen species (ROS)-sensitive sonosensitizer-integrated metal-organic frameworks (MOFs), denoted as P/M@CasMTH1, are developed for augmented sonodynamic therapy (SDT) efficacy using genome-editing technology....

Abstract Endogenic tumor chemodynamic therapy (CDT) is emerging as a tumor‐therapeutic strategy featuring in situ treatments with high efficiency and specificity based on the Fenton reaction principle. Considering limitation of monotherapy relatively insufficient intracellular level endogenous hydrogen peroxide (H 2 O ) tissues, mitochondria‐specific nanocatalyst composed cisplatin prodrug gallic acid‐ferrous (GA‐Fe(II)) nanocomposites successfully fabricated to fulfill...

Overcoming apoptosis resistance to achieve efficient breast cancer treatment remains a challenge. The precise induction of another form programmed cell death, pyroptosis, is an excellent alternative for treating cancer. Ultrasound (US)-enhanced enzyme dynamic (enzyodynamic) therapy developed by employing LaFeO3 (LFO) perovskite nanocrystals as substrate increase the rate deleterious reactive oxygen species (ROS) generation intensive pyroptosis. LFO possess quadruple enzyme-mimicking...

Atherosclerosis, driven by chronic inflammation in the artery walls, underlies several severe cardiovascular diseases. However, currently available anti-inflammatory-based strategies for atherosclerosis treatment suffer from compromised therapeutic efficacy and undesirable outcome. Herein, a distinct tetrapod needle-like PdH nanozyme was designed engineered efficient combinatorial reactive oxygen species (ROS) scavenging, hydrogen anti-inflammation, autophagy activation. After loading into...

Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost, sonodynamic therapy (SDT) still suffers from a quantum yield reactive oxygen species (ROS), limited delivery efficiency, potential toxicity sonosensitizers. Different direct sonosensitizers into tumor tissue for SDT, this work reports fabrication two-dimensional (2D) nanosonosensitizers/nanocatalysts (Ti3C2/CuO2@BSA) in situ generation nanosonosensitizers by responding to microenvironment, achieving...

The anticancer mechanism of nanozymes is dominantly associated with the capacity for generation reactive oxygen species (ROS) caused by valence change metal elements. However, very little research focused on and has achieved exploration development enzyme-mimicking activities valence-invariable compounds. Herein, a distinct calcium fluoride (CaF2 ) nanozyme ultrasound (US)-enhanced peroxidase (POD)-mimicking activity rationally designed engineered efficient (Ca2+ )-overload-enhanced...

Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant cancers, especially triple-negative cancer (TNBC), have evolved acquire specific antioxidant defense functions, significantly limiting killing efficiency SDT. Herein, authors engineered distinct single copper atom-doped titanium dioxide (Cu/TiO2 ) nanosonosensitizer with...

Abstract As a non‐invasive treatment modality with high tissue‐penetration depth, ultrasound‐triggered sonodynamic therapy (SDT) has been extensively explored and is regarded as the alternative choice to overcome drawbacks of conventional photo‐triggered therapies. Nevertheless, low quantum yield sonosensitizer, tumor hypoxia, undesirable therapeutic efficiency are still major concerns SDT. It highly challenging but necessary explore SDT‐based synergistic, augmented, noninvasive modalities....

Photothermal therapy (PTT) has emerged as a distinct therapeutic modality owing to its noninvasiveness and spatiotemporal selectivity. However, heat-shock proteins (HSPs) endow tumor cells with resistance heat-induced apoptosis, severely lowering the efficacy of PTT. Here, high-performance pyroelectric nanocatalyst, Bi13 S18 I2 nanorods (NRs), prominent conversion photothermal performance for augmented pyrocatalytic nanotherapy, is developed. Canonical binary compounds are reconstructed by...

Abstract Inducing ferroptosis has been acknowledged as an emerging strategy to kill drug‐resistant tumor cells, but how efficiently induce at the site and enhance its therapeutic efficacy are still highly challenging. In this work, ultrasound (US)‐augmented nanocatalytic is implemented by a GA‐Fe(II)‐based liposomal nanosystem, which simultaneously encapsulates doxorubicin hydrochloride (DOX), for reversing chemotherapeutic resistance inducing synergistic ferroptosis/apoptosis‐based...

Sonodynamic therapy (SDT), relying on the generation of reactive oxygen species (ROS), is a promising clinical therapeutic modality for treatment hepatocellular carcinoma (HCC) due to its noninvasiveness and high tissue-penetration depth, whereas oxidative stress antioxidative defense system in cancer cells significantly restrict prevalence SDT. Herein, we initially identified that NFE2L2 was immediately activated during SDT, which further inhibited SDT efficacy. To address this intractable...

Hypoxia, the typical and conspicuous characteristic of most solid tumors, worsens tumor invasiveness metastasis. Here, we engineered a sequential ultrasound (US)/hypoxia-sensitive sonochemotherapeutic nanoprodrug by initially synthesizing hypoxia-activated azo bond-containing camptothecin (CPT) prodrug (CPT2-Azo) then immobilizing it into mesopores sonosensitizer-integrated metal organic frameworks (MOF NPs). Upon entering hypoxic microenvironment (TME), structure CPT2-Azo immobilized MOFs...

Abstract The effective deployment of reactive oxygen species (ROS)‐mediated oncotherapy in practice remains challenging, mired by uncontrollable catalytic processes, stern reaction conditions and safety concerns. Herein, we develop a copper nanodot integrating sonodynamic effects within one active center, which responds to exogenous ultrasound (US) endogenous H 2 O stimuli. US irradiation induces the valence conversion from Cu II I catalyzing into ⋅OH for chemodynamic therapy. Meanwhile,...

As one of the most promising noninvasive therapeutic modalities, sonodynamic therapy (SDT) can focus ultrasound energy on tumor sites located in deep tissue and locally activate preloaded sonosensitizer to kill cells. However, exploring sonosensitizers with high SDT efficacy desirable biosafety is still a significant challenge. Herein, we utilized hydrophilic-hydrophobic self-assembly technology assemble hydrophobic organic dye Ce6 broad spectral anti-cancer agent Paclitaxel hydrophilic...

MXenes, a new class of two-dimensional (2D) nanomaterials, have shown enormous potential for biological applications. Notably, the development 2D MXenes in nanomedicine is still its infancy. Herein, distinct W1.33 C i-MXene with multiple theranostic functionalities, fast biodegradation, and satisfactory biocompatibility explored. By designing parent bulk laminate in-plane ordered (W2/3 Y1/3 )2 AlC ceramic optionally etching aluminum (Al) yttrium (Y) elements, nanosheets divacancies are...

Abstract Osteosarcoma (OS) is the primary malignant bone tumor. Despite therapeutic strategies including surgery, chemotherapy, and radiotherapy have been introduced into war of fighting OS, 5‐year survival rate for patients still remains unchangeable decades. Besides, critical defects after drug‐resistance side effects also attenuate predict poor prognosis. Recently, photothermal therapy (PTT) has attracted extensive attention featuring minimal invasiveness high spatial‐temporal precision...

Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal tumor hypoxia could enable oxygen-boosted PDT, but is limited by scant penetration depth and external light. Herein, aiming at dual purposes reducing biological toxicity induced long-term light irradiation alleviating hypoxia, we here introduce a novel-designed CaAl2O4:Eu,Nd blue persistent luminescence material (PLM) in...

Reactive oxygen species (ROS) has been employed as a powerful therapeutic agent for eradicating tumor via oxidative stress. As an emerging ROS-involving noninvasive anticancer modality, sonodynamic therapy (SDT) with high tissue penetration depth and benign remote spatiotemporal selectivity progressively utilized the distinct alternative ROS-based treatment. However, hypoxic microenvironment substantially restricts effect. In this work, self-sufficient hybrid sonosensitizer on basis of...

Abstract Bioorthogonal chemistry, referring to the rapid and selective synthesis of imaging and/or therapeutic molecules in live animals via transition metal‐mediated non‐natural chemical transformation without disrupting endogenous reactions, has greatly expanded tools techniques for biomedicine. However, owing safety concerns associated with metal toxicity, selectivity, sensitivity stability, efficient bioorthogonal reactions that can be reliably executed complex biological environments...

The local hypoxic tumor environment substantially hampers the therapeutic efficiency of radiotherapy, which typically requires large X-ray doses for treatment but induces serious side effects. Herein, a biomimetic radiosensitized platform based on natural in-situ oxygen-evolving photosynthetic cyanobacteria combined with two-dimensional (2D) bismuthene high atomic-number (Z) components, is designed and engineered to effectively modulate radiotherapy-resistant achieve sufficient radiation...

Abstract Background In comparison with traditional therapeutics, it is highly preferable to develop a combinatorial therapeutic modality for nanomedicine and photothermal hyperthermia achieve safe, efficient, localized delivery of chemotherapeutic drugs into tumor tissues exert tumor-activated nanotherapy. Biocompatible organic–inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) have shown high performance in molecular imaging drug as compared other inorganic nanosystems....