Hepatocellular carcinoma (HCC) is the fifth-most common cancer and third leading cause of cancer-related deaths worldwide. Increasing evidence indicates that dysregulation microRNAs often observed in HCC, has been extensively investigated terms formation, progression, diagnosis, therapy, prognosis. Recently, microRNA-326 (miR-326) demonstrated to play important roles multiple types human cancer. However, expression pattern, clinical significance, regulatory mechanisms miR-326 HCC have yet be...

To investigate the low-temperature adaptability of different provenances Ziziphus jujuba var. spinosa, we used 21 clones from seven as experimental materials and observed changes in physiological biochemical indicators characteristics anatomical structures under stress. A comprehensive evaluation their cold resistance was conducted using membership function method. As temperature decreased, relative electrical conductivity (REC) clone 89 became stable had lowest LT50 value (−44.04 °C). The...

Pink-flowered Prunus sibirica, of the genus Prunus, is an exceptional germplasm resource with high ornamental value. Understanding mechanism behind petal coloration crucial for cultivating P. sibirica varieties. This study utilized pink-flowered and white-flowered petals at different stages flowering to explore relationship between various physiological indicators, anatomical structures petals, flower during flowering. Results indicated that anthocyanins, key pigment indicators in directly...

The aim was to explore the alterations in growth traits, physiological and biochemical characteristics of Prunus sibirica seedlings raised from spaceflight seeds. cultivated by “Shenzhou XII” spacecraft carrying seeds superior clones P. were used observe their traits determine indicators. results showed that plant height increased 18–34% internode length 8–26%, but number primary branches, secondary leaves no significant change compared ground control. Leaf width significantly higher than...

As the large‐scale wind power penetration and distributed generation become popular in modern systems, governing control of pumped storage unit has attracted many attentions recent years for its flexible adjustment capability. To provide a research platform dynamic analysis hybrid system, micro‐grid mainly including plant is introduced detail taken as system plant. Refined mathematical models pump turbine, synchronous generator turbine have been established considering complicated non‐linear...

Due to frequent phosphoinositide 3‑kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway dysregulation, AKT is typically accepted as a promising anticancer therapeutic target. mTOR, in particular, represents suitable for hepatocellular carcinoma, whilst suppressor with morphogenetic effect on genitalia family member‑1 (SMG‑1) believed serve potential tumor role human cancer. Despite SMG‑1 and mTOR belonging the same PI3K‑related kinase family, interactions between them are...

The optimization of guide vane closing schemes (OGVCS) pumped storage hydro units (PSHUs) is a cooperative control and optimal operation research field in renewable energy power generation technology. This paper presents an OGVCS model PSHUs considering the rise rate unit rotational speed, specific node pressure each hydraulic unit, as well various complicated mechanical constraints. formulated multi-objective problem to optimize conflicting objectives, i.e., speed water hammer criteria. In...

The optimization of guide vane closing schemes (OGVCS) pumped storage hydro unit (PSHU) is the research field cooperative control and optimal operation storage, wind power solar generation. This paper presents a OGVCS model PSHU considering rise rate rotational speed specific node pressure each hydraulic unit, as well various complicated mechanical constraints. formulated multi-objective problem to optimize conflictive objectives, i.e., water hammer criteria. In order realize efficient...

• Premise of the study: A set novel expressed sequence tag (EST) microsatellite markers was developed in Pinus sylvestris var. mongolica to promote further genetic studies this species. Methods and Results: One hundred seventy‐five EST–simple repeat (SSR) primers were designed synthesized for 31,653 isotigs based on P. tabuliformis EST sequences. The primer pairs used identify 25 polymorphic loci 48 individuals. number alleles ranged from two eight with observed expected heterozygosity...

With increasing wind farm, solar and pump storage plant integrations, intense frequency fluctuation of the pumped hydro unit (PSHU) under no-load running condition, which is caused by its operation along S-shaped curve, has been noted researched. So, parameter identification PSHU regulation system (PSHURS) crucial in precise modeling can provide support for optimized control stability analysis power system. In this paper, a adaptive method together with an improved gravitational search...

Due to the reversible properties of pump turbine, its operation along "S" shape curve can lead unstable operation, like remarkable unit frequency oscillation, under unload condition. To solve problem, a robust non-fragile fractional order PID controller (FOPID) turbine governing system is proposed in this paper. Furthermore, combination bacterial foraging algorithm (BFA) and multi-scenario functions are employed select parameters for novel FOPID controller, which composed by time domain...

Determining the deformation trend of silt subsoil under long-term aircraft loading by conventional numerical methods based on finite elements is challenging and poses several limitations. In this study, a boundary surface model for remolded saturated considering influence soil dry density was developed, an explicit integral algorithm with error control used to incorporate into user-defined material subroutine that element software (ABAQUS 6.14) could call. way, consolidated undrained dynamic...

Abstract Prunus sibirica is an economically important forest tree with great development prospects. To study the mechanisms of male sterile P. , we compared phenotypic, cytological, and physiological characteristics clone 1 those fertile 60. Phenotypic included abnormal anther dehiscence, short unbent filaments, distorted pollen. Cytological features in emerged following late‐uninucleate stage were characterized by delayed tapetum degeneration, limited secondary thickening endothecium,...

Considering a precise mathematic model is the foundation of unit status evaluation, fault diagnosis and power system analysis, it necessary to identify parameters hydraulic turbine governing which can describe its characteristic appropriately. According linear mapping theory, white-box established. However, generation units are all running under regulation dispatch department strictly, makes difficult obtain enough operating data various inputs. To overcome problem shortage, RBF neural...

With the rapid development of process control theories in electrical engineering, new strategies which lead to better performances are urgently demanded for excitation synchronous generators. For sake improving convergence rate terminal voltage and covering weakness adaptability operational conditions conventional controls disturbances, a fuzzy predictive PID method is proposed this paper. This scheme can be divided into three steps every sample interval: parameter adaptation, rolling state...