A5053885152- Nutrition and Health in Aging
- Heart Failure Treatment and Management
- Renin-Angiotensin System Studies
- Ion Transport and Channel Regulation
- Frailty in Older Adults
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Catalytic Cross-Coupling Reactions
- Hormonal Regulation and Hypertension
- Phenothiazines and Benzothiazines Synthesis and Activities
- Body Composition Measurement Techniques
- Asymmetric Hydrogenation and Catalysis
- COVID-19 Clinical Research Studies
- GDF15 and Related Biomarkers
- Plant Molecular Biology Research
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Characterization of Heterocyclic Compounds
- Synthetic Organic Chemistry Methods
- Astrophysical Phenomena and Observations
- Plant nutrient uptake and metabolism
- Pancreatic function and diabetes
- Photosynthetic Processes and Mechanisms
- Synthesis and Reactions of Organic Compounds
- SARS-CoV-2 detection and testing
- Synthesis and Reactivity of Sulfur-Containing Compounds
University of Göttingen
2022-2025
German Centre for Cardiovascular Research
2023-2025
Okayama University Hospital
2025
Universitätsmedizin Göttingen
2023-2024
Tulane University
2012-2024
Yokohama City University Medical Center
2017-2023
Yokohama City University
2017-2023
Teikyo University
2021-2023
Niigata City General Hospital
2021-2023
Gunma University
2022
The purpose of this study was to determine the origin and subsequent spread feline calicivirus (FCV), herpesvirus (FHV), enteric coronavirus (FECV) in cats relinquished shelters. FCV isolated from oral fauces 11% healthy upon entry, isolation rates were highest for kittens (33%). FHV shedding very low (4%) at time entry occurred mainly juveniles. FECV also common among newly (33%), especially older juveniles (90%). all three viruses rapid efficient shelter environment. Fifteen percent FCV,...
Brain renin angiotensin system within the paraventricular nucleus plays a critical role in balancing excitatory and inhibitory inputs to modulate sympathetic output blood pressure regulation. We previously identified ACE2 ADAM17 as compensatory enzyme sheddase, respectively, involved brain Here, we investigated opposing contribution of hypothalamic presympathetic activity ultimately neurogenic hypertension. New mouse models were generated where selectively knocked down from all neurons...
The (pro)renin receptor is a newly discovered member of the brain renin-angiotensin system. To investigate role in hypertension, adeno-associated virus-mediated short hairpin RNA was used to knockdown expression nontransgenic normotensive and human renin-angiotensinogen double-transgenic hypertensive mice. Blood pressure monitored using implanted telemetric probes conscious animals. Real-time PCR immunostaining were performed determine receptor, angiotensin II type 1 vasopressin mRNA levels....
Cachexia, characterized by loss of muscle with or without fat mass, is a poor prognostic factor in patients heart failure (HF). However, there limited investigation on the impact and mass separately HF. We hypothesized that have different effects prognosis
Abstract ANAC071 and its homolog ANAC096 are plant-specific transcription factors required for the initiation of cell division during wound healing in incised Arabidopsis flowering stems hypocotyl grafts; however, mechanism remains mostly unknown. In this study, we showed that wound-induced cambium formation involved proliferation promoter activity TDR/PXY (cambium-related gene) stem. Prior to formation, both were expressed at these sites. anac- multiple mutants significantly decreased...
Trimethylamine N-oxide (TMAO), a metabolite derived from the gut microbiota, is proatherogenic and associated with cardiovascular events. However, change in TMAO secondary prevention therapies for ST-segment elevation acute myocardial infarction (STEMI) remains unclear. The purpose of this study was to investigate sequential levels response current patients STEMI clinical impact on events We included 112 measured plasma at onset 10 months later (chronic phase). After chronic-phase...
Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome, making it challenging to improve prognosis pharmacotherapy. Obesity one of the leading phenotypes HFpEF, and its prevalence continues grow worldwide. Consequently, obesity-targeted interventions have attracted attention as novel treatment strategy for HFpEF.
Abstract Zum Wohl! Zwei Alkohole (ein primärer und ein sekundärer) werden mithilfe eines Katalysesystems in Form von Silber‐Subnanoclustern auf γ‐Al 2 O 3 durch Wasserstoffautotransfer atomeffizient gekuppelt. Der wiederverwendbare Heterogenkatalysator fördert die Eintopf‐C‐C‐Kreuzkupplung Gegenwart katalytischer Mengen der schwachen Base Cs CO (siehe Reaktionsmechanismus). magnified image
The archetypical very-high-energy γ-ray blazar Mrk 421 was monitored for more than three years with the Gas Slit Camera on board Monitor of All Sky X-ray Image (MAXI), and its long-term variability investigated. MAXI light curve in 3–10 keV range transformed into periodogram frequency f = 1 × 10−8–2 10−6 Hz. artifacts periodogram, resulting from data gaps observed curve, were extensively simulated variations a power-law-like power spectrum density (PSD). By comparing periodograms, PSD index...
The importance of sarcopenia in cardiovascular diseases has been recently demonstrated. This study aims to examine whether skeletal muscle mass (SMM), an important component sarcopenia, is associated with increased risk poor outcome patients after ST-segment elevation myocardial infarction (STEMI).We measured SMM 387 STEMI using dual-energy X-ray absorptiometry. Patients were divided into low- and high-appendicular index (ASMI: appendicular by height squared (kg/m2)) groups the first...
Graphical AbstractIron deposition in the myocardium following intravenous iron therapy—by non-canonical pathway but not canonical (created with BioRender. com). Plasma NTBI levels increase rapidly after therapy FCM and are transported directly to cardiomyocyte through transporters such as L-type T-type calcium channels divalent metal transporter 1 within hours (non-canonical pathway). Iron taken up by remains a labile form for weeks FCM. FCM, ferric carboxymaltose; NTBI, non-transferrin...
We report a case of poorly differentiated pancreatic cancer that showed an exceptional response to combination therapy with nivolumab and metformin. A 58-year-old man presented epigastric pain was diagnosed locally advanced para-aortic lymph node metastasis. After disease progression following modified FOLFIRINOX (a fluorouracil, leucovorin, irinotecan, oxaliplatin), the patient enrolled in phase Ib clinical trial (3 mg/kg biweekly) combined metformin (750 mg/day). Post-treatment imaging...
Background: In 2023, Japan had the highest proportion of elderly in world, with one 10 individuals aged ≥80 years. Consequently, number patients cardiovascular diseases is increasing. Older often have comorbidities such as frailty, sarcopenia, and cognitive decline that leads to a decreased quality life (QOL). We analyzed effects outpatient cardiac rehabilitation (OCR) disease. Methods: The comprehensive OCR been provided by multidisciplinary team. data from 49 diseases, years, who received...
We present the catalog of high Galactic-latitude ($|b|>10^{\circ}$) X-ray sources detected in first 37-month data Monitor All-sky Image (MAXI) / Gas Slit Camera (GSC). To achieve best sensitivity, we develop a background model GSC that well reproduces based on detailed on-board calibration. Source detection is performed through image fit with Poisson likelihood algorithm. The contains 500 objects 4--10 keV band significance $s_{\rm D, 4-10 keV} \geq 7$. limiting sensitivity $\approx...
Sulfonylureas are categorized according to their binding sites of the ATP-sensitive K+ channel (K(ATP) channel) complex in pancreatic β-cells. The classified as A, B and A + site (both sites), respectively. Ser1369Ala variant sulfonylurea receptor gene ABCC8 which encodes a subunit K(ATP) has been demonstrated be associated with hypoglycemic effect gliclazide, binds site. However, on treatment sulfonylureas, such glimepiride or glibenclamide, is still uncertain.In case-control study, 32...