A5107480639- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Heart Failure Treatment and Management
- Synthesis and Biological Evaluation
- Cardiac Structural Anomalies and Repair
- X-ray Diffraction in Crystallography
- Reproductive System and Pregnancy
- Nanoplatforms for cancer theranostics
- Synthesis and biological activity
- Mechanical Circulatory Support Devices
- Chronic Lymphocytic Leukemia Research
- Cardiac pacing and defibrillation studies
- Crystallography and molecular interactions
- Acute Lymphoblastic Leukemia research
- Cancer therapeutics and mechanisms
- Photodynamic Therapy Research Studies
- Crystallization and Solubility Studies
- Transplantation: Methods and Outcomes
- Organometallic Complex Synthesis and Catalysis
- Pelvic and Acetabular Injuries
- Cardiovascular Function and Risk Factors
- Uterine Myomas and Treatments
- Berberine and alkaloids research
- Peptidase Inhibition and Analysis
- Structural and Chemical Analysis of Organic and Inorganic Compounds
Ponce Health Sciences University
2019-2024
Autonomous University of Tlaxcala
2023
Institut d'Etudes Politiques de Paris
2021
University of Puerto Rico-Mayaguez
2003-2019
University of Puerto Rico System
1999-2014
Monash Medical Centre
2009
Monash University
2009
Hospital Universitario Puerta de Hierro Majadahonda
2001-2007
University of Pittsburgh
2005
Scripps Mercy Hospital
2005
The generation of singlet oxygen (SO) in the presence specific photosensitizers (PSs) or semiconductor quantum dots (QDs) and its application photodynamic therapy (PDT) is great interest to develop cancer therapies with no need surgery, chemotherapy, and/or radiotherapy. This work was focused on identification main factors leading enhancement SO production using Rose Bengal (RB), Methylene Blue (MB) as PS species organic aqueous mediums. Subsequently, capacity zinc oxide (ZnO), sulfide...
Nonviral delivery systems are relatively easy to produce in the large scale, safe, and elicit a negligible immune response. Nanoparticles (NPs) offer promise as nonviral vectors biocompatible -degradable carriers of drugs with targeting specific sites by surface receptors monoclonal antibodies (mAbs). We investigated effect four PEG-PLGA (polyethylene glycol-polylactic-co-glycolic acid) NP on drug-resistant B-chronic lymphocytic leukemia (B-CLL) cells vitro, three them encapsulating drug,...
ABSTRACT Background and objective: Stable asthma is characterized by the production of Th2 cytokines, although Th1 cytokines may play a key role in aspects such as airway hyper‐responsiveness. This study explored cytokine profiles associated with exacerbation. Methods: Intracellular T‐cell was measured 16 children acute severe (emergency department), after convalescence (6 weeks, n = 13), stable disease (after 6 months, 7) 14 age‐matched hospital controls. Flow cytometry used to identify...
Benzazolo[3,2-a]quinolium salts (BQS) are cationic quaternary alkaloids with similar structure to the anticancer agent ellipticine. This study describes synthesis and screen, at experimental concentration of 10 mM, utilizing 60 cell line anti-cancer screening two BQS, namely, 7-benzyl-3- aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) corresponding nitrobenzimidazo[3,2-a]quinolinium (NBQ 48: D-763303). Compound ABQ-48: D-763307 was also screened in 5-dose NCI panel. These...
Endometriosis is a chronic gynecological disorder characterized by the growth of endometrial glands and stroma outside cavity producing inflammation pain. Previously we demonstrated that modulation hypothalamic pituitary adrenal (HPA) axis exacerbates development severity this condition. A physically active lifestyle has been shown to confer health benefits in many conditions potentially acting as stress buffer, thus hypothesized voluntary physical exercise can 'realign/reset' HPA resulting...
Abstract As part of our research efforts we had to prepare quantities bicyclo[3.1.0] hex-3-en-2-one (1). Attempts follow the previously described procedure for synthesis 1 produced unsatisfactory yields, consequently decided explore other synthetic approaches 1. The method herein envolves fewer steps and yields each step are quite satisfactory.
Objectives: The present study evaluates novel cationic quinoline derivatives known as benzimidazo[3,2- a ]quinolinium salts (BQS) named NBQ-48 and ABQ-48 that have structural similarities to anti-cancer substances such ellipticine berberine. Methods: Toledo human lymphoma (ATCC CRL2631) cells were treated for 24 48 hours. Apoptosis related endpoints cell cycle arrest, mitochondrial damage, RNS ROS generation the activity of several apoptosis proteins caspases inducing factor (AIF) studied...
Endometriosis is a complex gynecological disorder characterized by the ectopic growth of endometrial tissue. Symptoms endometriosis are known to impair quality life patients, and among these found dysmenorrhea, chronic pelvic pain, gastrointestinal (GI) issues. GI issues such as painful bowel movements, bloating constipation or diarrhea, one common reasons for misdiagnosis with irritable syndrome (IBS). Enteric glial cells (EGC) play role in pain associated IBS, reactive gliosis has been...
Abstract The electrochemical reduction of the chloride or perchlorate salts benzazolo[3,2‐ a ]quinolinium ion and several its analogues is reported. compounds studied are salt 3‐nitrobenzothiazolo‐and 3‐nitro‐9‐methoxybenzothiazolo[3,2‐ ]quinolinium, 7‐ethyl‐, 3‐nitro‐7‐methyl‐, 3‐nitro‐7‐ethyl‐, 3‐nitro‐7‐isopropyl‐, 3‐nitro‐7‐butyl‐ 3‐nitro‐7‐benzylbenzimidazolo[3,2‐ ]‐quinolinium, respectively. Cyclic voltammetry corresponding 3‐nitrobenzothiazolo[3,2‐ derivatives in N,N...