A5065614635- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Nutrition and Health in Aging
- Receptor Mechanisms and Signaling
- Transcranial Magnetic Stimulation Studies
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Immunotherapy and Immune Responses
- Stress Responses and Cortisol
- RNA regulation and disease
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Frailty in Older Adults
- S100 Proteins and Annexins
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- Sleep and Wakefulness Research
- Inflammasome and immune disorders
- Chemokine receptors and signaling
- Circadian rhythm and melatonin
- Hypothalamic control of reproductive hormones
Universidad de Murcia
2016-2025
Instituto Murciano de Investigación Biosanitaria
2021-2025
Weatherford College
2020
Complexo Hospitalario Universitario A Coruña
2020
Servicio Murciano de Salud
2020
Centro de Investigación Biomédica en Red
2008-2014
Biomedical Research Networking Center on Neurodegenerative Diseases
2009-2014
Universitat de València
1998
Abstract Inflammatory changes have been found in Parkinson's disease, humans intoxicated with the parkinsonian toxin MPTP, and animal models of disease. However, it is still not known whether inflammatory are responsible for active nerve cell death or if they a protective role against neurodegeneration. In this study, we analyzed glial reaction substantia nigra pars compacta (SNpc) striatum monkeys rendered parkinsosian by chronic MPTP injections. At postmortem examination 1 year after last...
The role of microglial motility in the context adult neurodegeneration is poorly understood. In present work, we investigated microanatomical details microglia-neuron interactions an experimental mouse model Parkinson's disease following intraperitoneal injection MPTP. specific intoxication dopaminergic neurons induces cellular polarization microglia, leading to formation body-to-body neuron-glia contacts, called gliapses, which precede neuron elimination. Inhibiting ROCK/Cdc42-mediated vivo...
Gut microbiota alteration (gut dysbiosis) occurs during the onset and progression of Parkinson's disease. dysbiosis biomarkers could be relevant to prodromal Urolithins, anti-inflammatory metabolites produced from some dietary polyphenols by specific gut microbial ecologies (urolithin metabotypes), have been proposed as composition functionality. However, this has not explored in disease patients. The current study aimed assess associations between urolithin metabotypes, severity...
The increase in life expectancy recent years has resulted a higher incidence of age-related diseases. Among these, osteoporosis and sarcopenia, collectively known as osteosarcopenia, have the most significant impact on quality life, general health frailty elderly. As for other diseases, pre-clinical studies these conditions are primarily limited by availability experimental model systems. Octodon degus ( O. ) is long-lived diurnal rodent identified potential tool ageing research. However,...
In the present work we analyze cerebellum of chronic parkinsonian monkeys in order to clarify whether mesencephalic depletion is associated with long term activation cerebellar neurons Parkinsonism. our study, observed a persistent Purkinje cells macaques, characterized by expression c-Fos, which correlated dopaminergic degeneration. These results are compatible fMRI Parkinson's disease patients, and may contribute understanding additional alterations brain circuitry
CCL2 is a chemokine involved in brain inflammation, but the way which it contributes to entrance of lymphocytes parenchyma unclear. Imaging cell type responsible for this task and details on how process takes place vivo remain elusive. Herein, we analyze that overexpresses multiple scenarios T-cell infiltration three different species. We observe CCL2+ astrocytes play part T-cells our analysis shows contact with perivascular occurs, suggesting may be an important event lymphocyte extravasation.
Parkinson disease is mainly characterized by the degeneration of dopaminergic neurons in central nervous system, including retina. Different interrelated molecular mechanisms underlying disease-associated neuronal death have been put forward brain, oxidative stress and mitochondrial dysfunction. Systemic injection proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to monkeys elicits appearance a parkinsonian syndrome, morphological functional impairments However, intracellular...
V. Annese, C. Barcia, F. Ros‐Bernal, A. Gómez, M. Ros, De Pablos, E. Fernández‐Villalba, M.‐E. Stefano and T. Herrero (2013) Neuropathology Applied Neurobiology 39, 132–143 Evidence of oligodendrogliosis in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced Parkinsonism Aims: Mice nonhuman primates administered with (MPTP) represent elective experimental models Parkinsonism, which degeneration the nigrostriatal dopaminergic pathway is associated prominent neuroinflammation,...
Neuroprotective strategies are becoming relevant to slow down dopaminergic cell death and inflammatory processes related the progressive neurodegeneration in Parkinson's disease (PD). Interestingly, among others, physical activity (PA) or anti-oxidant agents (such as N-acetyl-L-cysteine, NAC) common therapeutic strategies. Therefore, this study aims analyze if there is a synergistic effect of along with NAC treatment on degeneration neuroinflammatory response...