A5013947713- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Advanced Neuroimaging Techniques and Applications
- Nerve injury and regeneration
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Nuclear Receptors and Signaling
- Cytokine Signaling Pathways and Interactions
- Hereditary Neurological Disorders
- Stress Responses and Cortisol
- Heat shock proteins research
- Social Policies and Family
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- RNA regulation and disease
Université Paris-Saclay
2016-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2015-2022
Centre National de la Recherche Scientifique
2011-2022
CEA Paris-Saclay
2018-2022
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2015-2019
Université Paris-Sud
2015-2019
Direction de la Recherche Fondamentale
2016-2018
Institut d'Imagerie Biomédicale
2013-2016
Universidad de Murcia
2011-2013
Centro de Investigación Biomédica en Red
2012-2013
Astrocyte reactivity is a hallmark of neurodegenerative diseases (ND), but its effects on disease outcomes remain highly debated. Elucidation the signaling cascades inducing in astrocytes during ND would help characterize function these cells and identify novel molecular targets to modulate progression. The Janus kinase/signal transducer activator transcription 3 (JAK/STAT3) pathway associated with reactive models acute injury, it unknown whether this directly responsible for astrocyte...
Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer's disease. However, the specific role reactive astrocytes is still debated. This controversy may stem from fact that most strategies used to modulate astrocyte explore its contribution disease outcomes have only limited specificity. Moreover, now emerging heterogeneous cells all types not be controlled efficiently by strategies.Here, we cell type-specific approaches in vivo identified...
Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory that determine microglial actions pathological states. We examined role of glucocorticoid receptors (GRs), glucocorticoids released response stress and regulate inflammation, DN survival. Overall GR level was decreased substantia...
The role of microglial motility in the context adult neurodegeneration is poorly understood. In present work, we investigated microanatomical details microglia-neuron interactions an experimental mouse model Parkinson's disease following intraperitoneal injection MPTP. specific intoxication dopaminergic neurons induces cellular polarization microglia, leading to formation body-to-body neuron-glia contacts, called gliapses, which precede neuron elimination. Inhibiting ROCK/Cdc42-mediated vivo...
Abstract Huntington’s disease is a fatal neurodegenerative characterized by striatal neurodegeneration, aggregation of mutant Huntingtin and the presence reactive astrocytes. Astrocytes are important partners for neurons engage in specific response that involves morphological, molecular functional changes. How astrocytes contribute to still an open question, especially because their state poorly reproduced experimental mouse models. Here, we show JAK2-STAT3 pathway, central cascade...
Huntington's disease (HD) is an inherited neurodegenerative characterized by motor, cognitive and psychiatric symptoms. Atrophy of the striatum has been proposed for several years as a biomarker to assess progression in HD gene carriers. However, it does not provide any information about biological mechanisms linked pathogenesis. Changes brain metabolites have also consistently seen patients animal models using Magnetic Resonance Spectroscopy (MRS), but metabolite measurements are generally...
Abstract Inflammation is a characteristic feature of Parkinson’s disease (PD). We examined the role TLR9 and its regulation by glucocorticoid receptors (GRs) in degeneration substantia nigra dopamine neurons (DNs). agonist, CpG-ODN, induced DN mice lacking GR microglia but not controls. deletion reduced loss neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model PD. regulates activation during MPTP neurotoxicity as antagonist suppressed increased microglia/macrophage...
The precise contribution of astrocytes in neuroinflammatory process occurring Parkinson's disease (PD) is not well characterized. In this study, using GRCx30CreERT2 mice that are conditionally inactivated for glucocorticoid receptor (GR) astrocytes, we have examined the actions astrocytic GR during dopamine neuron (DN) degeneration triggered by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). results show significantly augmented DN loss mutant substantia nigra (SN) compared to...
CCL2 is a chemokine involved in brain inflammation, but the way which it contributes to entrance of lymphocytes parenchyma unclear. Imaging cell type responsible for this task and details on how process takes place vivo remain elusive. Herein, we analyze that overexpresses multiple scenarios T-cell infiltration three different species. We observe CCL2+ astrocytes play part T-cells our analysis shows contact with perivascular occurs, suggesting may be an important event lymphocyte extravasation.
The neurobiological functions of a number kinases expressed in the brain are unknown. Here, we report new findings on DCLK3 (doublecortin like kinase 3), which is preferentially neurons striatum and dentate gyrus. Its function has never been investigated. expression markedly reduced Huntington's disease. Recent data obtained studies related to cancer suggest could have an anti-apoptotic effect. Thus, hypothesized that early loss disease may render striatal more susceptible mutant huntingtin...
Ciliary neurotrophic factor (CNTF) is neuroprotective against multiple pathologic conditions including metabolic impairment, but the mechanisms are still unclear. To delineate CNTF effects on brain energy homeostasis, we performed a multimodal imaging study, combining in vivo proton magnetic resonance spectroscopy, high-performance liquid chromatography analysis, and situ glutamate by chemical exchange saturation transfer. Unexpectedly, found that expression through lentiviral gene transfer...
The role of astrocytes in the immune-mediated inflammatory response brain is more prominent than previously thought. Astrocytes become reactive to neuro-inflammatory stimuli through multiple pathways, contributing significantly machinery that modifies parenchymal environment. In particular, astrocytic signaling induces establishment critical relationships with infiltrating blood cells, such as lymphocytes, which a fundamental process for an effective immune response. interaction between and...
Abstract Huntington’s disease is a fatal neurodegenerative characterized by striatal neurodegeneration, aggregation of mutant Huntingtin and the presence reactive astrocytes. Astrocytes are important partners for neurons engage in specific response that involves morphological, molecular functional changes. How astrocytes contribute to still an open question, especially because their state poorly reproduced experimental mouse models. Here, we show JAK2-STAT3 pathway, central cascade...
Astrocytes are essential partners for neurons and their role in Huntington's disease (HD) is emerging. In HD, astrocytes change become reactive. Astrocyte reactivity characterized by morphological changes but its functional impact still unclear. To understand the roles of reactive we have developed viral vectors that infect selectively <i>in vivo</i> either block or induce reactivity, through manipulation JAK2-STAT3 pathway. We used these to modulate astrocyte two complementary mouse models...
Abstract Anticipated reactions to stressful situations are vital for the survival and well-being of organisms, abnormal involved in stress-related disorders. The neuropeptide oxytocin is a key modulator ensuring well-adapted stress responses. Oxytocin acts on both neurons astrocytes, but molecular cellular mechanisms mediating response remain poorly understood. Here, we focus amygdala, crucial hub that integrates processes sensory information through oxytocin- dependent mechanisms. Using an...
Astrocytes are essential partners of neurons in the central nervous system. In response to many brain diseases, astrocytes change at morphological, molecular and functional levels: they become reactive. These multiple changes likely have significant impacts on neurons, which dependent several astrocyte functions. Astrocyte reactivity is context-specific. It therefore determine occurring reactive each pathological situation, through dedicated selective approaches. This will promote...