A5035697205- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
- Infant Health and Development
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Evolutionary Psychology and Human Behavior
- Genetic Syndromes and Imprinting
- Essential Oils and Antimicrobial Activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Human-Animal Interaction Studies
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects of Natural Compounds
- Elasticity and Material Modeling
- Veterinary Pharmacology and Anesthesia
- Reproductive System and Pregnancy
- Biochemical Analysis and Sensing Techniques
- Morphological variations and asymmetry
- Adipose Tissue and Metabolism
- Phytochemistry and Biological Activities
- Regulation of Appetite and Obesity
- Child Development and Digital Technology
Institut des Neurosciences Cellulaires et Intégratives
2012-2024
Université de Strasbourg
2011-2024
Centre National de la Recherche Scientifique
2010-2022
Institut d'Etudes Avancées Paris
2016-2019
University of Lausanne
2011
Christie's
2009
Association pour la Recherche de Thérapeutiques Innovantes en Cancérologie
2009
Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral physiological expression of fear, but it is unknown whether these different aspects fear response can be separately regulated by CeA. We combined fluorescent retrograde tracing CeA that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings vivo monitoring related parameters. emerged from separate neuronal populations characteristics properties...
Abstract The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central and peripheral action. However, the precise pathways recruited by OT are largely elusive. Here we discovered a subset of neurons whose projections preferentially terminate on receptor (OTR)-expressing in ventrolateral periaqueductal gray (vlPAG). Using newly generated line transgenic rats (OTR-IRES-Cre), determined that most vlPAG OTR expressing cells targeted GABAergic. Ex vivo stimulation...
Neuropeptides, such as neuropeptide S (NPS) and oxytocin (OXT), represent potential options for the treatment of anxiety disorders due to their potent anxiolytic profile. In this study, we aimed reveal mechanisms underlying behavioral action NPS, present a chain evidence that effects NPS within hypothalamic paraventricular nucleus (PVN) are mediated via actions on local OXT neurons in male Wistar rats. First, retrograde studies identified fibers originating brainstem locus coeruleus,...
Oxytocin possesses several physiological and social functions, among which an important analgesic effect. For this purpose, oxytocin binds mainly to its unique receptor, both in the central nervous system peripheral nociceptive terminal axon skin. However, despite interesting properties current use clinics facilitate labor, is not used pain treatment. Indeed, it rapidly metabolized, with a half-life blood circulation estimated at five minutes cerebrospinal fluid around twenty humans rats....
Fast Inhibitory controls mediated by glycine (GlyRs) and GABAA receptors (GABAARs) play an important role to prevent the apparition of pathological pain symptoms allodynia hyperalgesia. The use positive allosteric modulators these receptors, specifically expressed in spinal cord, may represent interesting strategy limit or block expression. In this study, we have used stereoisomers progesterone metabolites, acting only via non-genomic effects, order evaluate contribution GlyRs GABAARs for...
Hypothalamospinal control of spinal pain processing by oxytocin (OT) has received a lot attention in recent years because its potency to reduce symptoms inflammatory and neuropathic conditions. However, cellular molecular mechanisms underlying OT antinociception are still poorly understood. In this study, we used biochemical, electrophysiological, behavioral approaches demonstrate that levels elevated the cord rats exhibiting symptoms, 24 h after induction inflammation with an intraplantar...
Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. thus project axons various cortical subcortical structures activate subpopulations increase the signal-to-noise ratio, turn, increases saliency of stimuli. Less about origin inputs neurons, but recent studies show cells projecting are often located...
The central processing of peripheral nociceptive messages is highly controlled by the activity local inhibitory networks in spinal cord and supraspinal centers. Recently, it has been shown that endogenous 3α-reduced neurosteroids (3αNS) exert a significant antinociception potentiating GABAA receptor function. Because 3αNS can be produced many relay structures system, we tested potential analgesic efficacy promoting production using etifoxine (ETX, 50 mg/kg i.p.). This prescribed...
Context: Menthol, the main monoterpene found in Mentha piperita L. (M. piperita) is known to modulate nociceptive threshold and present different curative preparations that reduce sensory hypersensitivities pain conditions. While for pulegone, a menthol-like monoterpene, only limited number of studies focus on its putative analgesic effects, pulegone most abundant Calamintha nepeta (L.) Savi (C. nepeta), plant Lamiaceae family used traditional medicine alleviate rheumatic disorders, which...
Here, we present a step-by-step protocol for three-dimensional reconstruction of astrocyte morphology, applied to the central amygdala oxytocin receptor-expressing astrocytes. This includes RNAse-free perfusion, combination RNAscope and immunohistochemistry, confocal imaging. provides detailed information about tissue handling comprehensive description RNAScope technique label rat mouse receptor mRNA. We also describe that allows assessment more than 70 different cellular parameters,...
Although cholinergic drugs are known to modulate nociception, the role of endogenous acetylcholine in nociceptive processing remains unclear. In current study, we evaluated transmission through spinal β(2)-subunit-containing nicotinic receptors control thresholds. We show that mechanical and thermal thresholds significantly lowered β(2)(∗)-knockout (KO) mice. Using antagonists these mice, demonstrate β(2)(∗)-nAChRs responsible for tonic inhibitory at level. further hypothesized β(2)(∗)-nAChR...
Abstract Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts potent analgesic effect through an action on the nociceptive system. endogenous control of pain important adaptive value but might be altered by early life stress, possibly contributing to long-term consequences responses and associated comorbidities. We tested this hypothesis using rat model...
Abstract Oxytocinergic actions within the hippocampal CA2 are important for neuromodulation, memory processing and social recognition. However, source of OTergic innervation, cellular targets expressing OT receptors (OTRs) whether PVN‐to‐CA2 system is altered during heart failure (HF), a condition recently associated with cognitive mood decline, remains unknown. Using immunohistochemistry along retrograde monosynaptic tracing, RNAscope novel OTR‐Cre rat line, we show that PVN (but not...
Abstract Heart failure (HF) patients suffer from cognitive decline and mood impairments, but the molecular signals brain circuits underlying these effects remain elusive. The hypothalamic neuropeptide oxytocin (OT) is critically involved in regulating mood, OTergic signalling central amygdala (CeA) a key mechanism that controls emotional responses including anxiety‐like behaviours. Still, whether an altered contributes to disorders HF remains unknown. To address this, we used ischaemic rat...