A5081911571- Neuroendocrine regulation and behavior
- Infant Health and Development
- Neuroscience of respiration and sleep
- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Infant Development and Preterm Care
- Neuropeptides and Animal Physiology
- Pain Management and Placebo Effect
- Stress Responses and Cortisol
- Musculoskeletal pain and rehabilitation
- Diet and metabolism studies
- Ion Channels and Receptors
- Anesthesia and Neurotoxicity Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Lysosomal Storage Disorders Research
- Neonatal and fetal brain pathology
- Treatment of Major Depression
- Carbohydrate Chemistry and Synthesis
- Trypanosoma species research and implications
- Biomedical Research and Pathophysiology
- Neonatal Health and Biochemistry
- Acupuncture Treatment Research Studies
- Blood Pressure and Hypertension Studies
- Pain Management and Treatment
- Aldose Reductase and Taurine
Université de Strasbourg
2016-2025
Institut des Neurosciences Cellulaires et Intégratives
2015-2025
Centre National de la Recherche Scientifique
2014-2025
Centre National pour la Recherche Scientifique et Technique (CNRST)
2023
Laboratoire de Neurosciences Cognitives et Adaptatives
2022-2023
Idorsia (Switzerland)
2020
Abstract The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central and peripheral action. However, the precise pathways recruited by OT are largely elusive. Here we discovered a subset of neurons whose projections preferentially terminate on receptor (OTR)-expressing in ventrolateral periaqueductal gray (vlPAG). Using newly generated line transgenic rats (OTR-IRES-Cre), determined that most vlPAG OTR expressing cells targeted GABAergic. Ex vivo stimulation...
Background: Aprocitentan is an orally active, dual endothelin (ET) receptor antagonist developed for the treatment of hypertension in which, despite available treatments, a medical need exists drugs with new mechanism action. Subjects and methods: In this study, single- multiple-dose tolerability, safety, pharmacokinetics (PK), pharmacodynamics up to 600 mg (single doses) 100 once day (qd; multiple aprocitentan were investigated healthy male female subjects. The effect age on tolerability PK...
Abstract Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts potent analgesic effect through an action on the nociceptive system. endogenous control of pain important adaptive value but might be altered by early life stress, possibly contributing to long-term consequences responses and associated comorbidities. We tested this hypothesis using rat model...
Abstract The nociceptive system of rodents is not fully developed and functional at birth. Specifically, C fibers transmitting peripheral information establish synaptic connections in the spinal cord already during embryonic period that only become after Here, we studied consequences neonatal maternal deprivation ( NMD , 3 h/day, P2–P12) on establishment fiber‐mediated neurotransmission pain‐related behavior. In vivo recording revealed excitation neurons could be observed P14 control but...
Aims: The authors evaluated the impact of first COVID-19 pandemic wave on French chronic pain structures (CPS). Methods: An online survey assessed CPS resource allocation, workflow and perceived patient care. Results: All was severely impacted by reallocation 42% specialists. In-person appointments were cancelled 72% participants. Follow-up maintained in 91% participants (telemedicine). Skills end-of-life decision-making/counseling rarely solicited. crisis experience patients high (eight out...
Noise and high light illumination in the neonatal intensive care unit (NICU) are recognized as stressors that could alter well-being development of vulnerable preterm infants. This prospective observational study evaluated pain behaviours very infants (VPIs) to sound peaks (SPs) levels variations (LLVs) NICU. We measured spontaneously occurring SPs LLVs incubators 26 VPIs over 10 h. Their behavioural responses were analysed through video recordings using "Douleur Aigue du Nouveau-né" (DAN)...
Abstract The hypothalamic neuropeptide, oxytocin (OT), exerts prominent analgesic effects via central and peripheral action. Here we discovered a novel subset of OT neurons whose projections preferentially terminate on receptor (OTR)-expressing in the ventrolateral periaqueductal gray (vlPAG). Using newly generated line transgenic rats (OTR-IRES-Cre), determined that most vlPAG OTR expressing cells being targeted by are GABAergic nature. Both optogenetically-evoked axonal release as well...
Virtual reality hypnosis (VRH) is a promising tool to reduce pain. However, the benefits of VRH on pain perception and physiological expression require further investigation.In this study, we characterized effects heat threshold among adult healthy volunteers while monitoring several autonomic functions.Sixty were prospectively included receive nociceptive stimulations. The first set thermal stimuli consisted 20 stimulations at 60°C (duration 500 milliseconds) trigger contact evoked...
Early neuronal processing of thermal noxious information relies mostly on molecular detectors the transient receptor potential family expressed by specific subpopulation sensory neurons. This may converge to second-order wide-dynamic-range (WDR) neurons located in deep layer dorsal horn spinal cord.Using a micro-Peltier thermode contact stimulator II delivering various cold and hot stimulations, we have characterized extracellular electrophysiological responses mechanosensitive WDR...
In this first-in-human study, the tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single multiple oral doses sinbaglustat, a dual inhibitor glucosylceramide synthase (GCS) non-lysosomal glucosyl ceramidase (GBA2), were investigated in healthy subjects. The single-ascending dose (SAD) multiple-ascending (MAD) studies randomized, double-blind, placebo-controlled. Single from 10 to 2,000 mg men 30 1,000 twice daily for 7 days male female subjects investigated. Tolerability,...
Abstract Early life adversities influence a nervous system still in development with long‐term consequences for later life. These include nociceptive circuit alterations critical to shape an adaptive pain response protect the organism from potential damage. Adult rats history of neonatal maternal separation (NMS) display visceral and somatic hypersensitivity inefficient analgesic responses stress. In this study, we have characterized NMS on wide dynamic range neurons (WDR) spinal cord...
Das Neuroeptid Oxytocin (OT) wird ausschließlich im Hypothalamus von magnozellulären Oxytocin-Neuronen (magnOT) und parvozellulären (parvOT) gebildet. Bisher war es v. a. dafür bekannt, dass als Kuschelhormon Körper z. B. bei der Entstehung Mutter-Kind-Bindung eine Rolle spielt oder Neurotransmitter die Stimmung das Sozialverhalten positiv beeinflusst. Nun gibt Hinweise darauf, OT auch einen Einfluss auf Schmerzwahrnehmung hat.
Early life adversities alter the development of a still maturing nervous system and can have long-term consequences on its function at adult age. This include nociceptive circuits that are critical to shape an adaptive pain response protect our organism from potentially damaging insults. As such, rats with history neonatal maternal separation (NMS) display visceral somatic hypersensitivity inefficient analgesic responses stress. In this study, we characterized NMS wide dynamic range neurons...