A5085810099- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Autism Spectrum Disorder Research
- Melanoma and MAPK Pathways
- Cell Image Analysis Techniques
- Axon Guidance and Neuronal Signaling
- Infant Health and Development
- Cancer Cells and Metastasis
- Primate Behavior and Ecology
- Functional Brain Connectivity Studies
- Advanced Causal Inference Techniques
- Morphological variations and asymmetry
- Neonatal and fetal brain pathology
- GDF15 and Related Biomarkers
- Tryptophan and brain disorders
- Congenital heart defects research
- Neuroinflammation and Neurodegeneration Mechanisms
- Meta-analysis and systematic reviews
University of Lausanne
2005-2024
Hôpital de Cery
2014
University Hospital of Lausanne
2003
Research Institute of Human Morphology
2001
University of Zurich
1998-2000
Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral physiological expression of fear, but it is unknown whether these different aspects fear response can be separately regulated by CeA. We combined fluorescent retrograde tracing CeA that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings vivo monitoring related parameters. emerged from separate neuronal populations characteristics properties...
Astrocytes orchestrate neural development by powerfully coordinating synapse formation and function and, as such, may be critically involved in the pathogenesis of neurodevelopmental abnormalities cognitive deficits commonly observed psychiatric disorders. Here, we report identification a subset cortical astrocytes that are competent for regulating dopamine (DA) homeostasis during postnatal prefrontal cortex (PFC), allowing optimal DA-mediated maturation excitatory circuits. Such control DA...
We previously have reported corpus callosum defects in transgenic mice expressing the β-amyloid precursor protein (βAPP) with a deletion of exon 2 and at only 5% normal levels. This finding indicates possible involvement βAPP regulation or guidance axon growth during neural development. To determine to what degree mutation interacts genetic background alleles that predispose for forebrain commissure some mouse lines, we assessed size commissures sample 298 mice. Lines mixed were compared...
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for generation of amyloid-β peptides (Aβ) implicated pathogenesis Alzheimer’s disease (AD). In this study, behavioral investigations revealed spatial learning and memory deficiencies our newly generated mouse line lacking APMAP. model AD, constitutive deletion worsened phenotype led to increased Aβ production deposition into senile plaques. To...
Islet-brain1/JNK-interacting protein-1 (IB1/JIP-1) is a scaffold protein that organizes the JNK, MKK7, and MLK1 to allow signaling specificity. Targeted disruption of gene <i>MAPK8IP1</i> encoding IB1/JIP-1 in mice led embryonic death prior blastocyst implantation. In culture, no IB1/JIP-1<sup>−/−</sup> embryos were identified indicating accelerated cell occurred during first cycles. expression was detected unfertilized oocytes, spermatozoa, different stages embryo development. Thus, despite...
Fragile X syndrome (FXS) is characterized by intellectual disability and autistic traits, results from the silencing of FMR1 gene coding for a protein implicated in regulation synthesis at synapses. The lack functional mental retardation has been proposed to result an excessive signaling synaptic metabotropic glutamate receptors, leading alterations synapse maturation plasticity. It remains, however, unclear how mechanisms activity-dependent spine dynamics are affected Fmr knockout (Fmr1-KO)...
Activation dynamics of hippocampal subregions during spatial learning and their interplay with neocortical regions is an important dimension in the understanding function. Using ( 14 C)-2-deoxyglucose autoradiographic method, we have characterized metabolic changes occurring mice while eight-arm radial maze task. Autoradiogram densitometry revealed a heterogeneous evolving pattern enhanced activity throughout hippocampus training period on recall. In early stages training, was CA1 area from...
Absence of statistical significance (i.e.,
Abstract Islet‐Brain 1, also known as JNK‐interacting protein‐1 (IB1/JIP‐1) is a scaffold protein mainly involved in the regulation of pro‐apoptotic signalling cascade mediated by c‐Jun–N‐terminal kinase (JNK). IB1/JIP‐1 organizes JNK and upstream kinases complex that facilitates activation. However, overexpression neurons vitro has been reported to result inhibition activation protection against cellular stress apoptosis. The occurrence functional significance stress‐induced modulations...
In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by image registration and voxel-wise statistical analysis of autoradiographs mouse brain sections. This tool has been in open-source ITK framework is freely available under GPL license. The presents complete processing chain from raw data acquisition group analysis. Results comparison context study on spatial learning are shown as an illustration...
Abstract Astrocytes control synaptic activity by modulating peri-synaptic concentrations of ion and neurotransmitters including dopamine and, as such, can be critically involved in the modulation some aspect mammalian behavior. Here we report that genetic mouse model with a reduced medial prefrontal cortex (mPFC) levels, arising from astrocyte-specific conditional deletion vesicular monoamine transporter 2 (VMAT2; aVMTA2cKO mice) shows excessive grooming anxiety-like behaviour. The VMAT2cKO...
Despite its established neuroprotective effect on dopaminergic neurons and encouraging phase I results, intraputaminal GDNF administration failed to demonstrate significant clinical benefits in Parkinson's disease patients. Different human doses were delivered the striatum of rats with a progressive 6-hydroxydopamine lesion using sensitive doxycycline-regulated AAV vector. treatment was applied either continuously or intermittently (2 weeks on/2 off) during 17 weeks. Stable reduction motor...
The ability to adapt one's behavior in response changing circumstances, or cognitive flexibility, is often altered neuropsychiatric and neurodevelopmental conditions. In rodents, flexibility frequently assessed using associative learning paradigms with a reversal component. majority of existing protocols rely on unrestrictive exploration no discouragement wrong responses are influenced by spatial cues, at least during the test's phase. Here, we present rewarded contingency discrimination...
It was not until after World War II that neurochemistry emerged as a distinct discipline in the United States with new technologieschromatography; electrophoresis