A5103069677- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Evolutionary Psychology and Human Behavior
- Microtubule and mitosis dynamics
- Nuclear Structure and Function
- RNA Research and Splicing
- Attachment and Relationship Dynamics
Hôpital de Cery
2020-2024
Université de Strasbourg
2011
The presence of a companion can reduce fear, but the neural mechanisms underlying this social buffering fear are incompletely known. We studied in male and female, its encoding amygdala male, auditory fear-conditioned rats. Pharmacological, opto,- and/or chemogenetic interventions showed that oxytocin signaling from hypothalamus-to-central projections underlied reduction acutely with retention 24 h later without companion. Single-unit recordings optetrodes central revealed fear-encoding...
SUMMARY Oxytocin orchestrates social and emotional behaviors through modulation of neural circuits in brain structures such as the central amygdala (CeA). The long-standing dogma is that oxytocin signaling nervous system occurs exclusively via direct actions on neurons. However, several findings over last decades showed astrocytes actively participate neuronal circuits. Here, we investigate degree astrocytes’ involvement functions. Using astrocyte’ specific gain loss function approaches,...
Abstract The presence of a companion can reduce fear, but the precise neural mechanisms underlying this social buffering fear (SBF) are incompletely known. We studied SBF encoding in amygdala rats that were fear-conditioned (FC) to auditory conditioned stimuli (CS). Pharmacological, opto,- and/or chemogenetic interventions showed oxytocin (OT) signaling from hypothalamus-to-central (CeA) projections was required for acute reduction presence, and retention 24h later absence companion....