A5049067226- Genetic Neurodegenerative Diseases
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Hereditary Neurological Disorders
- Photoacoustic and Ultrasonic Imaging
- Zebrafish Biomedical Research Applications
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Heat shock proteins research
- Traumatic Brain Injury and Neurovascular Disturbances
- Muscle Physiology and Disorders
- interferon and immune responses
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Ultrasound and Hyperthermia Applications
- Neurological Disease Mechanisms and Treatments
- Apelin-related biomedical research
- Neurological disorders and treatments
- Genetic Syndromes and Imprinting
- Cholinesterase and Neurodegenerative Diseases
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2016-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2016-2023
Servier (France)
2020-2023
Institut de Relations Internationales et Stratégiques
2023
Institut des Hautes Études Scientifiques
2023
University of Geneva
2023
Centre National de la Recherche Scientifique
2016-2022
Université Paris-Saclay
2021-2022
Le Laboratoire des Maladies Neurodégénératives
2019
Institut des Maladies Neurodégénératives
2019
Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer's disease. However, the specific role reactive astrocytes is still debated. This controversy may stem from fact that most strategies used to modulate astrocyte explore its contribution disease outcomes have only limited specificity. Moreover, now emerging heterogeneous cells all types not be controlled efficiently by strategies.Here, we cell type-specific approaches in vivo identified...
Abstract Huntington’s disease is a fatal neurodegenerative characterized by striatal neurodegeneration, aggregation of mutant Huntingtin and the presence reactive astrocytes. Astrocytes are important partners for neurons engage in specific response that involves morphological, molecular functional changes. How astrocytes contribute to still an open question, especially because their state poorly reproduced experimental mouse models. Here, we show JAK2-STAT3 pathway, central cascade...
Alzheimer's disease (AD) is characterized by cognitive decline and neuropathological hallmarks including Aβ plaques Tau tangles. Emerging evidence indicates oligodendrocyte (OL) dysfunction demyelination also contribute to progression. Here, we analyzed OL markers inflammatory gene expression in human hippocampal samples at early late AD stages. In AD, observed myelinating pathways downregulation, alongside microglial astrocytic activation, as well upregulated chemokine CCL2 peripheral...
Intracellular accumulation of tau protein is a hallmark Alzheimer’s Disease and Progressive Supranuclear Palsy, as well other neurodegenerative disorders collectively known tauopathies. Despite our increasing understanding the mechanisms leading to initiation progression pathology, field still lacks appropriate disease models facilitate drug discovery. Here, we established novel modulatable seeding-based neuronal model full-length 4R using humanized mouse cortical neurons seeds from P301S...
Abstract Huntington’s disease is a fatal neurodegenerative characterized by striatal neurodegeneration, aggregation of mutant Huntingtin and the presence reactive astrocytes. Astrocytes are important partners for neurons engage in specific response that involves morphological, molecular functional changes. How astrocytes contribute to still an open question, especially because their state poorly reproduced experimental mouse models. Here, we show JAK2-STAT3 pathway, central cascade...
Astrocytes are essential partners for neurons and their role in Huntington's disease (HD) is emerging. In HD, astrocytes change become reactive. Astrocyte reactivity characterized by morphological changes but its functional impact still unclear. To understand the roles of reactive we have developed viral vectors that infect selectively <i>in vivo</i> either block or induce reactivity, through manipulation JAK2-STAT3 pathway. We used these to modulate astrocyte two complementary mouse models...
Alzheimer′s disease (AD), the most common cause of dementia, represents one main clinical challenges century as number patients is predicted to triple by 2050. Despite recent approval three monoclonal antibodies targeting Amyloid β (Aβ) aggregates Food and Drug Administration (FDA), immunotherapies still face due difficulty crossing blood-brain barrier (BBB). This necessitates administering large doses drugs achieve their therapeutic effects, which associated with significant side effects....
Abstract Multiple lines of evidence point to peripheral immune alterations in bipolar disorder (BD) although the activity brain mechanisms remain largely unexplored. To identify cell type-specific BD brain, we performed a proteomic and single nuclear transcriptomic analysis postmortem cingulate cortex samples from control subjects. Our results showed that genes associated genetic risk for are enriched microglia astrocytes. Transcriptomic reduced proinflammatory phenotype, resistance...