A5042914240- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Chromatin Remodeling and Cancer
- interferon and immune responses
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Mental Health Research Topics
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Olfactory and Sensory Function Studies
- ATP Synthase and ATPases Research
- Immune Response and Inflammation
- Connexins and lens biology
University of Lausanne
2022-2024
Université Paris-Seine
2018-2022
Centre National de la Recherche Scientifique
2018
Inserm
2018
Sorbonne Université
2018
Institut de Biologie Paris-Seine
2018
Neurosciences Paris-Seine
2018
Abstract Inflammation is a characteristic feature of Parkinson’s disease (PD). We examined the role TLR9 and its regulation by glucocorticoid receptors (GRs) in degeneration substantia nigra dopamine neurons (DNs). agonist, CpG-ODN, induced DN mice lacking GR microglia but not controls. deletion reduced loss neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model PD. regulates activation during MPTP neurotoxicity as antagonist suppressed increased microglia/macrophage...
The precise contribution of astrocytes in neuroinflammatory process occurring Parkinson's disease (PD) is not well characterized. In this study, using GRCx30CreERT2 mice that are conditionally inactivated for glucocorticoid receptor (GR) astrocytes, we have examined the actions astrocytic GR during dopamine neuron (DN) degeneration triggered by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). results show significantly augmented DN loss mutant substantia nigra (SN) compared to...
Enduring behavioral changes upon stress exposure involve in gene expression sustained by epigenetic modifications brain circuits, including the mesocorticolimbic pathway. Brahma (BRM) and Related Gene 1 (BRG1) are ATPase subunits of SWI/SNF complexes involved chromatin remodeling, a process essential to enduring plastic expression. Here, we show that mice, social defeat induces BRG1 nuclear distribution. The inactivation Brg1/Smarca4 within dopamine-innervated regions or constitutive...
Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes components of mitochondrial electron transfer system render it an appropriate hub for coordinating adaption to oxygen levels. How under functional hypoxia (i.e., when intracellular O2 levels limit respiration) are relayed by impact remodeling after hypoxic exposure remains poorly defined. This is largely due challenges integrating findings...
Circular RNAs (circRNAs) are a large class of relatively stable RNA molecules that highly expressed in animal brains. Many circRNAs have been associated with CNS disorders accompanied by an aberrant wake-sleep cycle. However, the regulation brain homeostasis over daily light-dark (LD) cycles has not characterized. Here, we aim to quantify expression changes physiological conditions healthy adult animals. Using newly generated and public RNA-Seq data, monitored circRNA throughout 12:12 h LD...
Summary Cdr1as is a conserved circular RNA (circRNA) enriched in the CNS and important for maintaining brain homeostasis. The loss of results aberrant synaptic transmission deregulation stress response circadian clock genes. However, it not known whether expression or circRNAs, general, follows pattern different tissues. Here, using newly generated public RNA-Seq data, we monitor circRNA throughout rhythm various mouse regions. We demonstrate that , despite its stable character, has highly...