A5059595622- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ and Tissue Transplantation Research
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Pregnancy and Medication Impact
- Potassium and Related Disorders
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Hematopoietic Stem Cell Transplantation
- Diabetes Treatment and Management
- Adrenal Hormones and Disorders
- Neurological Complications and Syndromes
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Antifungal resistance and susceptibility
- Clostridium difficile and Clostridium perfringens research
- Pharmaceutical Practices and Patient Outcomes
- Oral and gingival health research
- Herpesvirus Infections and Treatments
Beth Israel Deaconess Medical Center
2007-2025
Novo Nordisk (United States)
2023
Massachusetts General Hospital
2019-2022
Harvard University
2012-2015
Rogers (United States)
2007-2012
University of Cincinnati
2003-2007
Hospital of the University of Pennsylvania
2007
Christ Hospital
2004
International Society for Heart and Lung Transplantation
2004
University of Cincinnati Medical Center
2004
Abstract: Background: Promising data regarding the safety and efficacy of gastric bypass surgery (GBS) as an option to address obesity in transplant population are emerging. The lack on how GBS may alter pharmacokinetics (PK) modern immunosuppression. objective this study was describe alterations PK immunosuppressants population. Methods: Data presented six subjects who participated trial – four were dialysis two renal recipients. Dialysis‐dependent received a single dose 6 mg sirolimus,...
Abstract These updated guidelines from the Infectious Diseases Community of Practice American Society Transplantation review management transplantation in HIV‐infected individuals. has become standard care for patients with HIV and end‐stage kidney or liver disease. Although less data exist thoracic organ pancreas transplantation, it is likely that also safe effective these recipients as well. Despite what typically a transient decline CD4 + T lymphocytes, remains well controlled infection...
Background. The first generic tacrolimus product gained Food and Drug Administration approval in August 2009. This prospective, observational trial sought to determine the need for dose titrations measure drug cost savings on conversion tacrolimus. Methods. Transplant recipients stable doses were converted from brand a mg:mg basis. Data collected at time of (study arm) point exactly 6 months before (control all subjects. Results. Seventy conversions four centers are reported. Subjects mean...
Abstract Background Many persons with HIV (PWH) are excluded as kidney transplants (KT) recipients due to guidelines recommending pre-transplant CD4 counts > 200 cells/mL. Historically, this threshold has been suggested concern for increased rates of infection among patients lower counts, however, it not rigorously studied and may be unnecessarily stringent leading exclusion otherwise acceptable organ candidates. Methods We performed a multicenter, retrospective cohort study...
West Nile virus infection has been spreading westward across the continental United States since 1999. Although it often presents as a mild, self-limiting viral illness, can result in devastating meningoencephalitis some patient populations, particularly elderly. We report this article on two immunosuppressed transplant patients who developed severe caused by mosquito-borne infection. Suggestions for prevention, diagnosis, and treatment of population are described.
With the advent of highly active antiretroviral therapy in mid-1990s, patterns morbidity and mortality patients with human immunodeficiency virus (HIV) infection have changed. HIV associated complications opportunistic infections declined end stage renal disease cirrhosis become increasingly important causes patient death(1Neuhaus J Angus B Kowalska JD et al.Risk all-cause nonfatal AIDS serious non-AIDS events among adults infected HIV.AIDS. 2010; 24: 697-706Crossref PubMed Scopus (138)...
In Brief Background Despite proven efficacy of prolonged cytomegalovirus (CMV) prophylaxis using valganciclovir 900 mg/day, some centers use 450 mg/day due to reported success and cost savings. This multicenter, retrospective study compared the safety 6 months low-dose versus high-dose in high-risk, donor-positive/recipient-negative, renal transplant recipients (RTR). Methods Two hundred thirty-seven high-risk RTR (low-dose group = [n 130]; s7]) were evaluated for 1-year CMV disease...
The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, part because concerns over uncontrolled HCV infection the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor-derived HCV-infection and should be administered early posttransplant period. However, evidence on safety efficacy immediate DAA treatment approach, including how manage logistical barriers...
Background. Weight gain is a known complication of corticosteroid maintenance therapy. The purpose the present study was to compare patterns weight under chronic therapy (CCST) with that observed early (i.e., within 7 days posttransplant) withdrawal (CSWD) in renal-transplant recipients. Methods. Renal-transplant recipients who underwent CSWD four prospective, institutional review board-approved clinical trials were compared historic control group patients receiving CCST. Results. One...
Abstract: The long‐term use of calcineurin inhibitors (CNI) leads to renal dysfunction in many liver transplant (LT) recipients. purpose this analysis is evaluate function patients converted from CNI sirolimus (SRL). From May 2002–November 2006, 137 LT were performed 125 patients, 72 which SRL. Evaluation SRL conversion was stratified by early (<90 d LT) (EC) vs. late (LC). Renal evaluated using the six‐point modification diet disease formula (estimated glomerular filtration rate [eGFR])....
Abstract Introduction During the coronavirus disease 2019 (COVID‐19) pandemic, transplant centers were challenged to meet demand for new telemedicine strategies. The ability of lung providers (LTP) conduct face‐to‐face clinic visits high‐risk immunocompromised patients, such as recipients (LTR), was limited. Through implementation comprehensive medication management visits, pharmacists able assist LTP in transition telemedicine. Methods A retrospective chart review telephone encounters from...
A number of studies have suggested that conversion from calcineurin inhibitors (CNI) to sirolimus (SRL) can improve graft function in renal transplant patients. None these has converted patients SRL the absence steroids.We describe our experience with 278 transplants which 153 were CNI SRL. The majority had steroids withdrawn after 6 days. Almost all received antithymocyte globulin induction and maintained on mycophenolate mofetil.Six months conversion, remaining therapy a mean increase...
Organs from donors after cardiac death (DCD) are being increasingly utilized. Prior reports of DCD kidney transplantation involve the use prednisone-based immunosuppression. We report our experience with early corticosteroid withdrawal (ECSW). Data on 63 transplants performed between 2002 and 2007 were analyzed. compared outcomes in 28 recipients maintained long-term corticosteroids (LTCSs) 35 that underwent ECSW. DGF occurred 49% patients ECSW 46% LTCS (p=0.8). There was no difference...