Despite being in existence for >40 years, the application of telemedicine has lagged significantly comparison to its generated interest. Detractors include immobile design most historic interventions and relative lack smartphones among general populace. Recently, exponential increase smartphone ownership familiarity have provided potential development mobile health (mHealth) that can be mirrored realistically clinical applications. Existing studies demonstrated some benefits mHealth various...

<b><i>Background:</i></b> Non-adherence to medication is a well-studied and known cause of late allograft loss, but it difficult measure prospectively monitor. The aim this study was assess if appointment non-adherence correlated with predictor graft outcomes. <b><i>Methods:</i></b> This longitudinal cohort that used the National United States Renal Data System veterans affairs health records data time-to-event analyses conducted impact on...

Low tacrolimus concentrations have been associated with higher risk of acute rejection, particularly within African American (AA) kidney transplant recipients; little is known about intrapatient variabilities impact on racial disparities.Ten year, single-center, longitudinal cohort study recipients. Intrapatient variability was assessed using the coefficient variation (CV) measured between 1 month posttransplant and clinical event, a comparable period in those without events. Pediatrics,...

In Brief Background Despite proven efficacy of prolonged cytomegalovirus (CMV) prophylaxis using valganciclovir 900 mg/day, some centers use 450 mg/day due to reported success and cost savings. This multicenter, retrospective study compared the safety 6 months low-dose versus high-dose in high-risk, donor-positive/recipient-negative, renal transplant recipients (RTR). Methods Two hundred thirty-seven high-risk RTR (low-dose group = [n 130]; s7]) were evaluated for 1-year CMV disease...

Background and objectives Medication safety events are predominant contributors to suboptimal graft outcomes in kidney transplant recipients. The goal of this study was examine the efficacy improving medication through a pharmacist-led, mobile health–based intervention. Design, setting, participants, & measurements This 12-month, single-center, prospective, parallel, two-arm, single-blind, randomized controlled trial. Adult recipients 6–36 months post-transplant were eligible....

Background. The aim of this analysis was to evaluate early signals the utility gene expression profile (GEP) and donor-derived cell-free DNA (dd-cfDNA) for ruling out subclinical rejection in multiorgan transplant recipients. Methods. This a prospective, single-center, observational pilot study that began enrolling patients September 2022. Participants were enrolled after providing informed consent had biomarker samples drawn before surveillance or for-cause biopsy. GEP result TX considered...

Abstract Studies have continued to evaluate risk factors associated with post‐transplant non‐adherence in pediatric patients. However, many of these studies fail how can be utilized predict MNA . The aims this study were (i) determine salient develop an adequate predictive model and (ii) assess transplant outcomes based on the presence a large, diverse cohort KTX recipients. One hundred seventy‐five solitary recipients transplanted from 1999 2013 included. AA, males, older patients, those...

The development, testing, and preliminary validation of a technology-enabled, pharmacist-led intervention aimed at improving medication safety outcomes in kidney transplant recipients are described.Medication issues, encompassing errors (MEs), nonadherence, adverse drug events (ADEs), predominant cause poor after transplantation. However, limited number clinical trials assessing the effectiveness technology have been conducted. Through an iterative, evidence-based approach,...

This was an economic analysis of a 12-month, parallel arm, randomized controlled trial in adult kidney recipients 6 to 36 months posttransplant (NCT03247322). All participants received usual care, while the intervention arm supplemental clinical pharmacist-led medication therapy monitoring and management, via smartphone-enabled mHealth app, integrated with risk-based televisits. Hospitalization charges were captured from study institution accounts payable non-study hospitalization estimated...

Abstract This national survey sought to determine the practices and policies pertaining opioid substitution therapy (OST) use in selection of liver transplant (LT) candidates. Of 114 centers, 61 (53.5%) responded survey, representing 49.2% LT volume 2016. Only two programs considered chronic (1 [1.6%]) or OST absolute contraindications transplant, while 63.9% 37.7% either one a relative contraindication, respectively. The majority did not have written policy regarding (73.8%) (78.7%) Nearly...

Modern immunosuppressant regimens have significantly decreased acute rejection rates, but may increased the risk of graft loss driven by adverse drug reactions (ADRs) and medication errors (MEs). The objectives this study were to determine incidence factors for MEs ADRs association between transplant outcomes these events.This was a post hoc analysis prospective, randomized trial that included patients aged>18 years received solitary renal at an academic medical center recruited March 2009...

A lack of research exploring post-transplant process optimization to reduce readmissions and increasing readmission rates at our center from 2009 2013 led this study, aimed assessing the effect patient factors on 30-d after kidney transplantation. This was a retrospective case-control study in adult transplant recipients. Univariate multivariate analyses were utilized assess determinants readmissions. 384 patients included; significantly associated with graft loss death (p = 0.001). Diabetes...

Abstract Purpose Nonadherence is a leading cause of death-censored allograft loss in kidney transplant recipients. Strong associations have tied tacrolimus intrapatient variability (IPV) to degree nonadherence and high IPV clinical endpoints such as rejection loss. dynamic, complex problem best targeted by multidimensional interventions, including mobile health (mHealth) technologies. Methods This was secondary planned analysis 12-month, parallel, 2-arm, semiblind, 1:1 randomized controlled...

<b><i>Background/Aims:</i></b> There are no published studies assessing the safety and efficacy of thiazides as antihypertensives in kidney transplantation (KTX). <b><i>Methods:</i></b> This was a longitudinal retrospective cohort study conducted adult KTX recipients. Patients were grouped based on receiving following KTX. Safety comparisons made between thiazide recipients unexposed patients, well change blood pressure (BP) within patients....

OIs present significant risks to patients following solid organ transplantation. The purpose of this study was identify risk factors for the development after kidney transplantation in pediatric and evaluate impact on outcomes patient population. A single-center retrospective longitudinal cohort analysis including 21 yr age or younger transplanted from July 1999 June 2013 at an academic medical center conducted. Patients were excluded if they received multi-organ transplant. total 175...

Hepatitis C is the leading indication for liver transplantation in USA and recurrence universal. The impact of preexisting diabetes, new-onset diabetes after transplant (NODAT), glycemic control on fibrosis progression has not been studied. This retrospective longitudinal cohort study included adult recipients with hepatitis transplanted between 2000 2011. Patients were divided into three groups: (n = 41), NODAT 59), no 103). (70%) or (59%) more likely to develop (≥stage 1 fibrosis), as...

Abstract Opioid use after kidney transplant has been shown to be a risk factor for chronic opioid use, which leads an increased of mortality. The purpose this study was evaluate the early impact multimodal pain regimen and education quality improvement program on 2 months implementation. This retrospective, single‐center analysis post‐operative comparing average daily Morphine milligram equivalents (MME) patients who received opioids (preoperative TAP/QL block, scheduled APAP gabapentin)...

Medication errors, adverse drug events, and nonadherence are the predominant causes of graft loss in kidney transplant recipients lead to increased healthcare utilization. Research has demonstrated that clinical pharmacists have unique education training identify these events early develop strategies mitigate or prevent downstream sequelae. In addition, studies utilizing mHealth interventions success improving control chronic conditions deterioration.The goal prospective, randomized TRANSAFE...

Opioid use following kidney transplant is associated with an increased risk of graft loss and mortality. minimization strategies protocols have shown reductions in short-term opioid after transplant.