A5004271239- Occupational and environmental lung diseases
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Histone Deacetylase Inhibitors Research
- Systemic Lupus Erythematosus Research
- Receptor Mechanisms and Signaling
- Metastasis and carcinoma case studies
- Reproductive Physiology in Livestock
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Analytical Chemistry and Chromatography
- Asymmetric Hydrogenation and Catalysis
- Immunodeficiency and Autoimmune Disorders
- Hernia repair and management
- Pleural and Pulmonary Diseases
- Asthma and respiratory diseases
- Pharmacological Receptor Mechanisms and Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Signaling Pathways in Disease
- Protein Kinase Regulation and GTPase Signaling
- Glycosylation and Glycoproteins Research
- Pharmacological Effects of Natural Compounds
Országos Korányi Tbc és Pulmonológiai Intézet
2016-2023
Semmelweis University
2020-2023
National Institute of Oncology
2023
University of Pecs
2021
Budapest University of Economics and Business
2019
University of Debrecen
2001-2018
Thales (Portugal)
2008
University of Szeged
2004-2005
University of Arizona
1998
Stanford University
1994
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain-interacting protein (SHARPIN), heme-oxidized IRP2 ligase-1 (HOIL-1), and HOIL-1-interacting (HOIP), is a critical regulator inflammation immunity. This highlighted by the fact that patients with perturbed ubiquitination caused mutations in Hoip or Hoil-1 genes, resulting knockouts these proteins, may simultaneously suffer from immunodeficiency autoinflammation. TLR3 plays crucial, albeit...
Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data obtained by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). In first mouse model, only sunitinib exhibited broad-spectrum activities simultaneously suppressing vascular...
Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzed aminocarbonylation in micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and temperature with CO gas introduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) rapidly optimized reactions, which required less than 2 min. The method gave improved results over comparable batch techniques is also suited...
Abstract Purpose: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed investigate dual targeting HDAC inhibition and chemotherapy SCLC. Experimental Design: The efficacy HDACi SCLC was investigated both vitro vivo. Synergistic drug interactions were calculated based on HSA...
No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) 2D and 3D cultures vivo. IC50 values were measured by adherent cell viability assay. Cell migration growth quantified video microscopy spheroid formation, respectively. Phosphorylation of FAK, Akt, S6, Erk was immunoblot. The mRNA expression putative tumor...
Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role tumor angiogenesis growth various experimental systems. We investigated apelin signaling malignant behavior cutaneous melanoma. Murine B16 A375 melanoma cell lines were stably transfected with encoding or control vectors. Apelin overexpression significantly increased migration invasion vitro, but it had no impact on its proliferation. In our vivo experiments, number size lung...
Purpose: Malignant pleural mesothelioma (MPM) is an aggressive thoracic tumor type with limited treatment options and poor prognosis. The angiokinase inhibitor nintedanib has shown promising activity in the LUME-Meso phase II MPM trial thus currently being evaluated confirmatory III trial. However, anti-MPM potential of not been studied preclinical setting.Experimental Design: We have examined antineoplastic various vitro vivo models human MPM.Results: Nintedanib's target receptors were...
Inflammatory cytokines can impair the skin barrier, but question as to whether barrier alterations affect keratinocyte immune responses remains unanswered. The aim of this study was investigate immune-mediated inflammation differs between severe atopic dermatitis patients with or without filaggrin mutation. levels filaggrin, inflammatory T helper 2 polarizing (thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL-33)) chemokine (C-C motif) ligand 27 (CCL27), histological severity...
While papillary thyroid cancer (PTC) has largely favorable prognosis, anaplastic (ATC) is a rare but extremely aggressive malignancy with grim clinical outcome. Even though new therapeutic options are emerging for ATC, additional preclinical models and novel combinations needed specific subsets of patients. We established cell line (PF49) from the malignant pleural effusion 68-year-old male patient ATC that rapidly transformed BRAF TERT promoter mutant PTC. PF49 cells demonstrated robust...
Malignant pleural mesothelioma (MPM) is a rare malignancy with dismal prognosis. While the epithelioid type associated more favourable outcome, additional factors are needed to further stratify prognosis and identify patients who can benefit from multimodal treatment. As MPM shows remarkable morphological variability, prognostic role of five defined morphologies, impact nuclear grading system mitosis-necrosis score were investigated in this study.Tumour specimens 192 European centres...
<i>Background: </i>In recent years, new physiological functions of vitamin A have been identified, including its role in immune defense. The antioxidant potential carotenoids is thought to account for their health benefits. aim this study was investigate the concentration changes provitamin-A (α- and-β-carotene, β-cryptoxanthin) and non-provitamin-A (lutein, zeaxanthin lycopene) children with acute infections. <i>Methods:</i> Serum retinol carotenoid concentrations...
Abstract We have studied the expressions of various protein kinase C (PKC) isoenzymes in T cells and monocytes from patients with systemic lupus erythematosus (SLE), comparison to those healthy controls other immunological disorders. As measured by Western blotting, levels PKCβ, δ, η, ε, θ ζ (but not PKCα) significantly decreased SLE patients. In monocytes, however, we observed marked suppressions only PKCδ, ε but PKC isoforms. vivo corticosteroid application, as well vitro steroid treatment...
The coding sequence of the human m2 receptor gene was amplified by polymerase chain reaction and stably transfected into a murine fibroblast cell line (B82). We have compared M2 clonal (HM2-B10) with previously established B82 (M2LKB2-2) expressing rat to assess drug specificity, selectivity effector coupling. Both lines showed high level specific, saturable [3H](-)-N-methyl-3-quinuclidinyl benzilate binding Kd values 243 pM (155-352 pM) 345 (234-539 Bmax 97 +/- 4 338 16 fmol/10(6) cells,...
The authors report a large family in which bipolar disorder appears to cosegregate with autosomal-dominant medullary cystic kidney disease.Information regarding diagnostic criteria for and disease were gathered from members through formal research interviews, hospital admission records, imaging reports, laboratory data.Of the seven disease, five had I disorder, one unipolar depression, hyperthymic phenotype. Information was not available on two members.The cosegregation this suggests close...