A5012822305- Toxoplasma gondii Research Studies
- Malaria Research and Control
- Disaster Response and Management
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Travel-related health issues
- Vector-borne infectious diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Viral Infections and Vectors
- Burn Injury Management and Outcomes
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
- Hip and Femur Fractures
- Quality and Supply Management
- Trauma and Emergency Care Studies
- Thermal Regulation in Medicine
- Antimicrobial agents and applications
- Poisoning and overdose treatments
- Coccidia and coccidiosis research
- Brucella: diagnosis, epidemiology, treatment
- Wound Healing and Treatments
- Bone fractures and treatments
- Streptococcal Infections and Treatments
Walter Reed Army Institute of Research
2021-2025
Walter Reed National Military Medical Center
2013-2021
Uniformed Services University of the Health Sciences
2007-2020
National Center for Infectious Diseases
2005
Washington University in St. Louis
2002-2004
Circulating murine monocytes comprise two largely exclusive subpopulations that are responsible for seeding normal tissues (Gr-1-/CCR2-/CX3CR1high) or responding to sites of inflammation (Gr-1+/CCR2+/CX3CR1lo). Gr-1+ recruited the site infection during early stages immune response intracellular pathogen Toxoplasma gondii. A model toxoplasmosis was thus used examine importance in control disseminated parasitic vivo. The recruitment intimately associated with ability suppress parasite...
Abstract Three clonal strain types (I, II, and III) of Toxoplasma gondii predominate worldwide. The outcome infection in mice is highly dependent on the parasite genotype with type I strains being uniformly virulent, while II III are nonvirulent. Interactions innate immune response play a major role determining murine model. To identify key early differences that contribute to pathogenesis, we examined cytokine production macrophages after vitro parasites virulent nonvirulent genotypes....
Background: War-trauma, especially due to blast injury, can be associated with long bone fracture. Immediate external fixation of fractures, followed by internal when the patient is medically stabilized (damage control orthopedics [DCO]), U.S. Army policy for war-related fractures. Data on infectious outcomes DCO used war-trauma fractures are scant. Methods: A retrospective review patients from 2003 2007 femoral or tibial treated was conducted. Fisher's Exact and Mann-Whitney tests were...
Toxoplasma gondii is a common protozoan parasite that causes disease in immunocompromised humans. Equipped with wide array of experimental tools, T. has rapidly developed as model for genetic studies. The population structure highly clonal, consisting three distinct lineages differ dramatically virulence. Acute virulence probably mediated by the differences distinguish strain types. We have utilized combination approaches to investigate acute toxoplasmosis using mouse model. These studies...
Plasmodium falciparum malaria remains a significant global health challenge. Current vaccines elicit antibody responses against circumsporozoite protein (PfCSP) that prevent the infection of hepatocytes but offer only moderate protection. Cellular immunity has emerged as critical component pre-erythrocytic protection might be leveraged to develop improved PfCSP vaccines. Here, we characterized clonality, molecular features, epitope specificity, and HLA-restrictions human PfCSP-specific CD4+...
Abstract Q fever is an emerging infectious disease among US soldiers serving in Iraq. Three patients have had atypical manifestations, including 2 with acute cholecystitis and 1 patient respiratory distress syndrome. Providers must be aware of fever’s signs symptoms to avoid delays treatment.
The global burden of malaria remains substantial. Circumsporozoite protein (CSP) has been demonstrated to be an effective target antigen, however, improvements that offer more efficacious and durable protection are still needed. In support research development next-generation vaccines, Walter Reed Army Institute Research (WRAIR) developed a CSP-based antigen (FMP013) novel adjuvant ALFQ (Army Liposome Formulation containing QS-21). We present single center, open-label, dose-escalation Phase...
Background: Infection is the most frequent complication after severe burns and remains predominant cause of death. Burn patients may require multiple courses antibiotics, lengthy hospitalizations, invasive procedures that place burn at especially high risk for infections with multi-drug–resistant organisms (MDROs). Methods: The published literature on MDROs in was reviewed to develop a strategy managing these infections. Results: Within unit meticulous infection prevention control measures...
USA300 methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of skin and soft-tissue infection (SSTI) in military personnel. MRSA has emerged as an important healthcare-associated bloodstream (BSI) metropolitan centers.To determine the prevalence, risk factors, patient outcomes associated with BSI tertiary medical centers.Retrospective case-control study.Patients admitted during period 2001-2009 BSI.Walter Reed Army Medical Center (Washington, DC) National Naval (Bethesda, MD)...
Multidrug-resistant infections complicating combat-related trauma necessitate the use of broad-spectrum antimicrobials. Recent literature posits an association between vancomycin (VANC) and piperacillin-tazobactam (VPT) combination therapy acute kidney injury (AKI). We examined whether with VPT was associated increased risk AKI compared to VANC other β-lactam antibiotics (VBL) following injuries.Patients within Trauma Infectious Disease Outcomes Study (TIDOS) who received ≥48 hours...
ABSTRACT We report a case of febrile Plasmodium falciparum malaria in 36-year-old male patient occurring 14 years after immigration from and more than 12 months since return visit to the endemic area. The critical need for awareness regarding late presentations P. is discussed.
ABSTRACT Lyme disease is a vector-borne infection that can affect multiple different organ systems. carditis represents one of these sequelae and defined by acute onset high-grade atrioventricular block in the presence laboratory-confirmed infection. Current guidelines recommend patients with be admitted for close cardiac monitoring intravenous antibiotics therapy. Our case illustrates an active duty male who was initially diagnosed after reporting symptoms including headache, fever, eye...
Studies of vancomycin (VANC) and piperacillin–tazobactam (VPT) induced acute kidney injury (AKI) have included diverse populations obscuring clinical generalizations. To our knowledge, previous studies omitted combat-related trauma patients despite frequent exposure to broad-spectrum antimicrobials. Our objective was analyze whether combination therapy with VPT associated an increased risk AKI compared VANC other β-lactam antibiotics (VBL). Patients within the Trauma Infectious Disease...
The exercise of leadership demands leaders draw upon multiple capabilities in order to simultaneously enforce standards and achieve mission success while successfully nurturing candor engagement within the organization. following case highlights one officer’s challenge related balancing requirements with aspirations personnel.