A5071587735- Inflammatory mediators and NSAID effects
- Systemic Lupus Erythematosus Research
- Cancer, Stress, Anesthesia, and Immune Response
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Adenosine and Purinergic Signaling
- Cytokine Signaling Pathways and Interactions
- Microscopic Colitis
- Body Image and Dysmorphia Studies
- Cancer, Hypoxia, and Metabolism
- Polyomavirus and related diseases
- Liver Diseases and Immunity
- Neonatal Respiratory Health Research
- Cardiovascular Function and Risk Factors
- Pregnancy and preeclampsia studies
- Syphilis Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Innovations in Medical Education
- Medical Imaging and Pathology Studies
- Eicosanoids and Hypertension Pharmacology
- Cardiac Valve Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Nephrotoxicity and Medicinal Plants
The University of Queensland
2021-2025
Royal Brisbane and Women's Hospital
2021-2023
Woman's Hospital
2023
Westmead Hospital
2020-2021
Canberra Hospital
2018-2021
Sydney Local Health District
2021
University of Wollongong
2017
Abstract Background To determine the safety and efficacy of biological agents used in treatment systemic lupus erythematosus (SLE) adults. Methods Systematic review meta-analysis following PRISMA guidelines. Data sources MEDLINE (through Pubmed), EMBASE, Cochrane library, Clinicaltrials.gov, Australianclinicaltrials.gov.au, ANZCTR.org.au WHO International Clinical Trials Registry Platform for studies published from 20 May 2021 15 years prior. A grey literature search was performed completed...
Translationally controlled tumour protein TCTP is an anti-apoptotic frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. may be involved protecting cancer cells against the cytotoxic action of anti-cancer drugs. Here we study early increase human colorectal (CRC) and regulation expression HCT116 colon cells, response to treatment drugs 5-FU oxaliplatin.Using immunohistochemistry, assessed surgical samples from adenomas adenocarcinomas colon,...
ABSTRACT New‐onset lupus nephritis (LN) poses a diagnostic and management challenge during pregnancy. This is more pertinent in the indigenous population, where prevalence higher, clinical phenotype tends to be severe. We report case of 30‐year‐old G3P2 female, living remote Queensland, with late presentation nephrotic syndrome at 30 weeks gestation. A diagnosis Class V LN was made without kidney biopsy due maternal foetal risk, she empirically treated steroids disease‐modifying agents good...
Co-infection with human immunodeficiency virus-1 (HIV) and syphilis is associated rapid progression to tertiary syphilis. This case report describes the early development of gummatous skin disease suspected neurosyphilis in a patient untreated HIV approaches treatment.
Abstract Background Pregnancy-related Atypical Haemolytic Uremic Syndrome (P-aHUS) is a rare condition affecting genetically predisposed women during pregnancy. It often difficult to diagnose and has significant impact on maternal foetal outcomes. characterised by microangiopathic haemolytic anaemia kidney injury from thrombotic microangiopathy. Case presentation A 27-year-old female of Lebanese descent presented at 36 weeks’ gestation with death in-utero (FDIU) placental abruption...
Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by extraordinary heterogeneity, due to the complex pathogenesis and diverse manifestations. Stratification of patients for therapy prognosis represents major challenge manage SLE. Conventional biomarkers diagnosis activity assessment provide very limited insight into immunological therapeutic response rates. The advancement “omics” technologies including genomics, transcriptomics, proteomics,...
Background: Acute interstitial nephritis is often associated with drug therapy. It can be a common cause of acute kidney injury, traditional chemotherapy agents have been various forms renal damage, but this not commonly seen anti-hormone Here we report case aromatase inhibitor the use letrozole. Case Presentation: We present an 84-year-old female commended on letrozole for management estrogen sensitive breast cancer. The patient developed oliguric injury 3-weeks after initiation, creatinine...
C3 glomerulonephritis is a recently described entity with heterogeneous histopathological features. This study was conducted to assess the effect of reclassification glomerulopathies on renal outcomes, mortality, and response therapy.
Abstract Background: To determine the safety and efficacy of biological agents used in treatment systemic lupus erythematosus (SLE) adults. Methods: Systematic review meta-analysis following PRISMA guidelines Data sources: MEDLINE (through Pubmed), EMBASE, Cochrane library, Clinicaltrials.gov, Australianclinicaltrials.gov.au, ANZCTR.org.au WHO International Clinical Trials Registry Platform for studies published from 20 May 2021 15 years prior. A grey literature search was performed...
TCTP overexpression partially protects mammalian cells against the cytotoxic effects of 5-FU and oxaliplatin. We utilised a previously established model cell line that stably overexpresses [26]. These are bovine mammary epithelial cells, where one harbours TCTP-overexpressing plasmid (white bars), control empty vector (black bars). The were cultured in DMEM supplemented with 10% FCS, 50 mg/ml hygromycin B 5 mg/ml insulin. Cells subjected to treatment indicated concentrations or Cell growth...
A 50-year-old Bangladeshi female with a background of Lupus, presented biopsy proven thrombotic microangiopathy. She underwent empiric plasma exchange limited efficacy, subsequently her ADAMTS-13 activity retuned to be normal excluding thrombocytopenic purpura. was then treated prednisolone, and Rituximab for possible Lupus flare, minimal response. Due ongoing haemolysis progressive kidney injury diagnosis atypical haemolytic uremic syndrome (aHUS) made Eculizumab therapy commenced. During...
Background: Near-to-peer teaching involves more experienced learners acting as tutors for junior colleagues and has significant theoretical benefits both teachers [1-3]. Aim: Development, implementation, assessment of a weekend examination preparation workshop by Royal Australasian College Physicians Advanced Trainees (ATs) Basic Physician (BPTs), using near-to-peer framework. Methods: A two-day offsite course was designed ATs. Day 1 - subspecialty short-case demonstrations, followed...