A5067621651- Gastroesophageal reflux and treatments
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Infant Health and Development
- Eosinophilic Esophagitis
- Digestive system and related health
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Child and Adolescent Health
- Respiratory Support and Mechanisms
- Intestinal Malrotation and Obstruction Disorders
- Radiation Dose and Imaging
- Immunodeficiency and Autoimmune Disorders
- Parathyroid Disorders and Treatments
- Dermatology and Skin Diseases
- Dysphagia Assessment and Management
- Pediatric Pain Management Techniques
- Appendicitis Diagnosis and Management
- Clinical Nutrition and Gastroenterology
- Asthma and respiratory diseases
Poole Hospital NHS Foundation Trust
2013-2024
Dorset HealthCare University NHS Foundation Trust
2024
Oxford University Hospitals NHS Trust
2021-2023
University of Oxford
2021-2023
Poole Hospital
2014-2023
AbbVie (United States)
2019-2023
University Hospital Southampton NHS Foundation Trust
2008-2023
Bristol Royal Hospital for Children
2022
University of the West of England
2022
University of Dundee
2021
A 3 year old boy is brought to his general practitioner again by worried mother. She concerned that he remains constipated despite trying a third different laxative. Further history showed passed first meconium only on day 5, and since then has been opening bowels weekly, with associated straining. His growth fallen from the 25th 2nd centile for height weight. On examination distended abdomen palpable stool throughout abdomen. Hirschsprung's disease characterised an absence of ganglion cells...
Faecal calprotectin (FC) is a neutrophil-derived protein released in stool response to mucosal inflammation. It simple, cheap and non-invasive test with high sensitivity moderate specificity, which can be useful the diagnosis monitoring of inflammatory bowel disease (IBD). FC levels correlate well inflammation (both macroscopic histological activity) are not influenced by location or type IBD. Despite shortcoming regards it that makes valuable screening tool especially effective identifying...
### What you need to know A 3 year old boy is brought his general practitioner by mother. She worried he waking at night complaining of abdominal pain. He has smelly stools that float in the toilet, and a cousin with coeliac disease. His growth fallen from 25th second centile for height weight. On examination distended, mildly tender abdomen wasted buttocks. Laboratory results are strongly positive disease an IgA anti-tissue transglutaminase (anti-tTG) concentration 134 IU/mL (normal range...
This 13-year-old boy presented with a 2-month history of abdominal pain, bloody diarrhoea and weight loss (10 kg). On examination, he was wasted had non-tender, reticular, macular, pigmented rash on his anterior wall (fig 1). He attributed the to frequent use hot water bottle, which helped settle pain. Inflammatory markers were raised, …
Paroxysmal cold haemoglobinuria (PCH) accounts for around a third of cases autoimmune haemolytic anaemia in children. PCH is caused by an autoantibody that fixes complement to red cells at low temperatures and dissociates warmer (a biphasic haemolysin), triggering complement-mediated intravascular haemolysis. Named the Donath-Landsteiner (D-L) antibody after its discoverers, it usually formed response infection demonstrates specificity ubiquitous cell P-antigen. A D-L test can be used detect...
Abstract Background Point-of-care testing (POCT) is diagnostic performed at or near to the site of patient. Understanding current capacity, and scope, POCT in this setting essential order respond new research evidence which may lead wide implementation. Methods A cross-sectional online survey study use was conducted between 6th January 2nd February 2020 on behalf two United Kingdom (UK) Ireland-based paediatric networks (Paediatric Emergency Research UK Ireland, General Adolescent Paediatric...
Thomas Moshang, Missouri: Elsevier Mosby, 2004, £34.99 (hardback), pp 282. ISBN 0323018254 Studying paediatric endocrinology is like staring into the waters of Loch Ness. In cold light a Scottish day it possible to see few inches murky depths, and while most visitors are comfortable seeing loch’s surface, consider plumbing dark gives one an eerie feeling about what could lie beneath (encouraged by locals). Like mythical monster, rarer syndromes often subject fragmented fables, discussed...
Introduction: Emollients provide an occlusive barrier for dry and atopic skin, retain moisture, protect it from irritants, form the basis of eczema treatment. Methods Analysis: A prospective interventional single arm study to evaluate performance safety Epaderm ® Cream, emollient cleanser containing 25% (w/w) paraffin 5% glycerine (thereafter, cream), in patients with skin conditions. The primary outcome measure was participant evaluation moisturisation after treatment cream up 4 weeks....
Objective Gastro-oesophageal reflux disease (GORD) is a common condition affecting children, characterised by the passage of gastric contents into oesophagus causing pain, vomiting and regurgitation. Children with neurodisability (such as cerebral palsy; CP) are predisposed to more severe GORD due coexisting gut dysmotility exclusive/supplementary liquid diet; however, there no existing tools or outcome measures assess severity in this patient group. For children without CP, ‘Paediatric...