A5014104768- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Endometriosis Research and Treatment
- RNA regulation and disease
- Reproductive System and Pregnancy
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Consumer Attitudes and Food Labeling
- Cancer Immunotherapy and Biomarkers
- Nutritional Studies and Diet
- Animal Genetics and Reproduction
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Obesity, Physical Activity, Diet
- Gut microbiota and health
- Lung Cancer Research Studies
University of Zagreb
2022-2024
Deciphering the cellular history of different cancers is critical for understanding tumor development and improving diagnostic therapeutic strategies in oncology. Previous studies have shown that chromatin accessibility normal cell transformation (COT) a major determinant cancer's mutational landscape. We leveraged single-cell data from 559 healthy subsets to predict COT across 36 cancer subtypes, providing unprecedented scale resolution into beginnings cancers. Our machine learning model...
Non-communicable diseases (NCD) and lifestyle, particularly diet, have a close relationship. Based on the recent statistics, Croatian men women lead in European overweight lists, which implies pessimistic prognosis terms of incidence prevalence NCDs future. One possible solutions to overcome weight problems is turn traditional balanced sustainable diets, such as Mediterranean diet. In this study, we assessed adherence towards diet using validated questionnaire an online survey associated...
Abstract The molecular mechanisms underlying the transition from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) are incompletely understood. During development of NAFLD, Perilipin 5 (PLIN5) can regulate lipid metabolism by suppressing lipolysis and preventing lipotoxicity. Other reports suggest that lack PLIN5 decreases hepatic injury, indicating a protective role in NAFLD pathology. To better understand disease, we established mouse models NAFLD-induced HCC,...
Background/Objectives: Cell lines do not faithfully replicate the authentic transcriptomic condition of disease under study. The HepG2 cell line is widely used for studying hepatocellular carcinoma (HCC), but all biological processes and genes exhibit congruent expression patterns between actual disease. objective this study to perform a comparative analysis line, HCC, primary hepatocytes (PH) in order identify suitable research as model PH or HCC research. Methods: We conducted differential...
Background: Gene-agnostic genomic biomarkers were recently developed to identify homologous recombination deficiency (HRD) tumors that are likely respond treatment with PARP inhibitors. Two machine-learning algorithms predict HRD status, CHORD, and HRDetect, utilize various HRD-associated features extracted from whole-genome sequencing (WGS) data show high sensitivity in detecting patients BRCA1/2 bi-allelic inactivation all cancer types. When using only DNA mutation for the detection of...
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, ranking as sixth common cancer worldwide and fourth leading cause of cancer-related deaths. Most HCC cases originate from cirrhotic livers, typically due to chronic diseases, such hepatitis B (HBV) C (HCV) infections, alcoholism. cells often harbor numerous somatic mutations that are implicated in development, but epigenetic factors, miRNA interference, can also affect initiation progress. miRNA-221 has been explored...
Introduction Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as the leading cause of hepatocellular carcinoma (HCC) worldwide. Over years, Perilipin 5 (PLIN5) been recognized a key regulator both MAFLD and HCC development. In our previous studies we demonstrated that deficiency in Plin5 reduces severity mice. Interestingly, it established patients with exhibit various changes their gut microbiome profiles. The itself shown to play role modulating carcinogenesis...
The incidence of nonalcoholic fatty liver disease (NAFLD) has been steadily increasing in Western society recent years and recognized as a risk factor for the development hepatocellular carcinoma (HCC). However, molecular mechanisms underlying progression from NAFLD to HCC are still unclear, despite use suitable mouse models. To identify transcriptional lipid profiles livers mice with NAFLD-HCC, we induced both NAFLD-HCC pathologies C57BL/6J performed RNA-sequencing (RNA-seq) targeted...