A5045065364- Lymphoma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Chronic Lymphocytic Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Ovarian cancer diagnosis and treatment
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Adrenal and Paraganglionic Tumors
- Cancer-related molecular mechanisms research
- Transplantation: Methods and Outcomes
- Multiple and Secondary Primary Cancers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Intraperitoneal and Appendiceal Malignancies
- Hematological disorders and diagnostics
- Galectins and Cancer Biology
- Neuroblastoma Research and Treatments
- Apelin-related biomedical research
- Gastrointestinal Tumor Research and Treatment
Klinička bolnica Merkur
2014-2025
University of Zagreb
2016-2025
University Hospital Dubrava
2010-2023
Children's Hospital Zagreb
2023
Zagreb School of Business
2019
Klinički Bolnički Centar Rijeka
2018
Sisters of Charity Hospital
2018
University of Split
2018
Scientific and Production Association of Electromechanics (Russia)
2011
Abstract Symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) is a rare, symmetrical skin eruption triggered by various medications, predominantly beta‐lactam antibiotics. We report the case of 69‐year‐old male with moderate‐to‐severe ulcerative colitis who developed SDRIFE following seventh intravenous administration infliximab. The patient presented symmetrical, pruritic erythema in cubital popliteal fossae, groins, gluteal retroauricular regions without systemic...
Abstract To model the cytogenetic evolution in gastrointestinal stromal tumour (GIST), an oncogenetic tree was reconstructed using comparative genomic hybridization data from 203 primary GISTs (116 gastric and 87 intestinal GISTs, including 151 newly analysed cases), with follow‐up available 173 cases (mean 40 months; maximum 133 months). The identified three major pathways: one initiated by − 14q, 1p, another 22q. 14q pathway mainly characterized tumours predominantly stable karyotypes more...
N- and O-glycans are attractive clinical biomarkers as glycosylation changes in response to diseases. The limited availability of defined specimens impedes glyco-biomarker identification validation large patient cohorts. Formalin-fixed paraffin-embedded (FFPE) the common form sample preservation pathology, but qualitative quantitative O-glycomics such samples has not been feasible date. Here, we report a highly sensitive glycan isomer selective method for simultaneous from histopathological...
The mast-cell sarcoma of a bone is described here for the first time. tumour presented in 4-year-old boy, with pain, oedema and deformation his right lower leg. Radiological findings revealed destructive tumourous mass. Histopathological examination showed to be composed large, atypical cells, hyperchromatic oval polygonal nuclei. cytoplasm around them was eosinophilic many basophilic toluidine-blue-positive granules. These mast cells were positive chloroacetate esterase, c-kit, tryptase...
Primary renal well-differentiated neuroendocrine tumour (NET) (hereafter referred to as NET) is rare, with ~100 cases having been reported in the literature. There are also limited data on molecular-genetic background of primary NETs.We analysed 11 NETs by using next-generation sequencing (NGS) identify characteristic genetic aberrations. All tumours were positive for synaptophysin, and expressed insulinoma-associated protein 1 (10/11), chromogranin-A (8/11), CD56 (3/11). Cytoplasmic...
According to the World Health Organization classification of neoplastic diseases hematopoietic and lymphoid tissues, diffuse large B-cell lymphoma comprises about 40% adult cases non-Hodgkin s lymphoma. It consists following morphological variants: 1) centroblastic (with or without multilobulated nuclei); 2) immunoblastic (>90% immunoblasts); 3) T cell/histiocytes rich; 4) anaplastic. Rare variants plasmablastic type, mediastinal (thymic) lymphoma, intravascular, primary effusion are...
Semaphorins are a diverse family of immunoregulators recently recognized to play major role in various phases immune responses. Their chronic viral hepatitis C (CHC) and contribution the progression liver disease is unknown. The aim this study was analyse association secreted semaphorins with severity patients CHC. Serum concentrations were measured 114 treatment-naive CHC 36 healthy controls. SEMA3A, SEMA3C, SEMA5A, SEMA6B SEMA6D significantly increased compared While serum SEMA3C fibrosis...
AimTo investigate the association of gastric histological and endoscopic findings in patients with Helicobacter pylori (H. pylori), according to presence seropositivity 12 bacterial virulence antigens.MethodsThis is a cross-sectional single-center study 360 consecutive outpatients referred period one year upper gastrointestinal endoscopy because dyspeptic complaints. Patients sera were tested by Western blot method determine serum antibodies antigens – p120 (CagA cytotoxin-associated...
Hodgkin lymphomas (HLs) are a heterogeneous group of lymphoid neoplasia associated with Epstein-Barr virus (EBV) infection. EBV, considered to be an important etiological co-factor in approximately 1% human malignancies, can classified into two genotypes based on EBNA-2, EBNA-3A and EBNA-3C sequences, genetic variants the sequence variation gene coding for LMP1 protein. Here, we present results distribution EBV 1 2 as well 50 patients EBV-positive classical HL selected from cohort 289...
Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked chronic low-grade inflammation and progression. Semaphorins, a large family of biological modifiers, were recently recognized as one the key regulators responses, possibly also diseases. The aim this study was to identify semaphorins NAFLD their relationship steatosis fibrosis stages. In prospective, case-control study, serum semaphorin concentrations (SEMA3A, -3C, -4A, -4D, -5A -7A)...
Hodgkin lymphoma (HL) is a biologically diverse group of lymphoid tumors, which accounts for 1% all de novo neoplasms in the world's population. It divided into two main groups: more common classic (cHL) and less nodular lymphocyte-predominant (NLPHL). cHL further four subtypes, differ morphology contents tumor microenvironment. Macrophages are one components microenvironment known to contribute creating an immunosuppressive microenvironment, inhibits activity cells expressing granzyme B...
Abstract: The authors describe 10 cases of sebaceoma that manifested prominent infundibulocystic structures in all and, additionally, conspicuous squamous metaplasia 6 neoplasms. All tumors occurred on the scalp or face (2 lacked clinical information) and presented as a solitary lesion, measuring from 5 to 20 mm. patients' age ranged 22 89 years. main component was small, uniform basaloid cells (immature sebocytes) intermixed with mature sebocytes clearly arranged nodules, classifying...
Internal carotid artery (ICA) aneurysms are rare. The symptoms related to cerebral embolization, local compression and rupture. Options for treatment include open surgery or endovascular with a covered stent. We report case of 67 year old woman bilateral idiopathic internal aneurysms, found during the diagnostic evaluation an episode syncope. right ICA aneurysm was treated resection end-to-end anastomosis ICA. There were no perioperative complications. Six months later patient underwent...
Proliferation rate is a major determinant of the biologic behavior tumor and provides information that can be used to guide treatment decisions.This ring study included 27 pathologists from 14 Institutions, in order assess inter-observer concordance between Croatia. We analyzed Ki-67 proliferative index on ten randomly selected breast cancer samples comparing consistency visual assessment using light microscopy compared digital image analyses results one central laboratory as referral...
Celiac disease is the most common chronic gastroenterological autoimmune characterized by gluten intolerance. The diagnosis of celiac and enteropathy-associated T cell lymphoma often made when it too late. Case report describes a 35-year-old female patient managed for one year under inflammatory bowel admitted to our hospital exacerbation underlying disease. However, was ruled out diagnostic work-up, while clinical picture findings obtained raised suspicion lymphoma. patient’s condition...
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, ranking as sixth common cancer worldwide and fourth leading cause of cancer-related deaths. Most HCC cases originate from cirrhotic livers, typically due to chronic diseases, such hepatitis B (HBV) C (HCV) infections, alcoholism. cells often harbor numerous somatic mutations that are implicated in development, but epigenetic factors, miRNA interference, can also affect initiation progress. miRNA-221 has been explored...