A5008979776- Osteoarthritis Treatment and Mechanisms
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
- Rheumatoid Arthritis Research and Therapies
- Bone Metabolism and Diseases
- Cancer-related gene regulation
- Connective tissue disorders research
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- High Altitude and Hypoxia
- Caveolin-1 and cellular processes
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Vitamin D Research Studies
- Pulmonary Hypertension Research and Treatments
- Platelet Disorders and Treatments
- Knee injuries and reconstruction techniques
- Gastrointestinal Tumor Research and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Flavonoids in Medical Research
- Medical Imaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- Gastrointestinal disorders and treatments
University of Gothenburg
2023-2025
Otto-von-Guericke University Magdeburg
2018-2025
Science for Life Laboratory
2023-2025
University Hospital Magdeburg
2017-2018
Abstract To model the cytogenetic evolution in gastrointestinal stromal tumour (GIST), an oncogenetic tree was reconstructed using comparative genomic hybridization data from 203 primary GISTs (116 gastric and 87 intestinal GISTs, including 151 newly analysed cases), with follow‐up available 173 cases (mean 40 months; maximum 133 months). The identified three major pathways: one initiated by − 14q, 1p, another 22q. 14q pathway mainly characterized tumours predominantly stable karyotypes more...
Calcification of cartilage with basic calcium phosphate (BCP) crystals is a common phenomenon during osteoarthritis (OA). It directly linked to the severity disease and known be associated hypertrophic differentiation chondrocytes. One morphogen regulating chondrocyte Wnt3a.Calcification sulfation extracellular matrix was analysed over time course from 6 22 weeks in mice different OA grades human cartilage. Wnt3a ß-catenin stained murine Expression modulating enzymes (HS2St1, HS6St1) using...
Interleukin-11 (IL-11) is a member of the IL-6 family cytokines and possesses both pro- anti-inflammatory properties. IL-11 activates its target cells via binding to membrane-bound IL-11R subsequent formation homodimer signal-transducing receptor gp130. Thus, expression pattern determines which can be activated by IL-11. However, knowledge about that secrete are sparse, overall roles in inflammatory diseases largely unexplored. In this study, we show high amounts detected ELISA synovial...
Septic arthritis, the most severe joint disease, is frequently caused by Staphylococcus aureus (S. aureus). A substantial proportion of patients with septic arthritis experience poor outcomes, often necessitating replacement surgery. Here, we show that monocyte depletion confers full protection against bone erosion in a mouse model. In infected synovium, Ly6Chi monocytes exhibited increased expression osteoclastogenesis-related molecules, including CCR2, c-Fms, and RANK. S. lipoproteins...
Objective Syndecan-4 (sdc4) is a cell-anchored proteoglycan that consists of transmembrane core protein and glucosaminoglycan (GAG) side chains. Binding soluble factors to the GAG chains sdc4 may result in dimerisation initiation downstream signalling cascades. However, question how affects response cells inflammatory stimuli unknown. Methods Sdc4 immunostaining was performed on rheumatoid arthritis (RA) tissue sections. Interleukin (IL)-1 induced extracellular signal-regulated kinases (ERK)...
Disease-modifying drugs have improved the treatment for autoimmune joint disorders, such as rheumatoid arthritis, but inflammatory flares are a common experience. This work reports development and application of flare-modulating poly(lactic-co-glycolic acid)-poly(ethylene glycol)-maleimide (PLGA-PEG-MAL)-based nanoparticles conjugated with joint-relevant peptide antigens, aggrecan70–84 type 2 bovine collagen256–270. Peptide-conjugated PLGA-PEG-MAL encapsulated calcitriol, which acted an...
Abstract Background Activated fibroblast-like synoviocytes (FLS) are drivers of synovitis and structural joint damage in rheumatoid arthritis (RA). Despite the use disease-modifying drugs, only about 50% RA patients reach remission real-world settings. We used an unbiased approach to investigate effects standard-of-care methotrexate (MTX) a Janus kinase inhibitor, tofacitinib (TOFA), on gene expression RA-FLS, order identify untargeted disease mediators. Methods Primary RA-FLS were activated...
Structural homology modeling supported by bioinformatics analysis plays a key role in uncovering new molecular interactions within gene regulatory networks. Here, we have applied this powerful approach to analyze the orchestrating death receptor signaling In particular, focused on mechanisms of CD95-mediated NF-κB activation and c-FLIP/NEMO interaction induction pathway.To end, created model complex using reported structure v-FLIP/NEMO complex, rationally designed peptides targeting complex....
Over the last 30 years, prevalence of osteoarthritis (OA), a disease characterized by loss articular cartilage, has more than doubled worldwide. Patients suffer from pain and progressive joint function. Cartilage is an avascular tissue mostly consisting extracellular matrix with embedded chondrocytes. As such, it does not regenerate naturally, which makes early onset OA prevention treatment necessity to sustain patients’ quality life. In recent engineering strategies for regeneration...
The rheological properties of synovial fluid (SF) are essential for the friction behavior and wear performance total joint replacements. Standardized in vitro tests endoprosthesis recommend diluted calf serum, which exhibits substantial different compared to SF. Therefore, test conditions do not mimic vivo conditions. SF samples from osteoarthritis knee patients undergoing revision surgery were biochemically rheologically. flow synthetic constituents, such as bovine serum albumin (BSA)...
Age alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in response. IgG glycosylation fragment crystallizable (Fc) region, including sialylation, is important regulating effector function by interacting Fc gamma receptors (FcγRs). Glycosylation fundamentally changed age and inflammatory responses. We aimed explore regulation of humoral comparing responses antigen-induced challenges...
Background: Chondrocalcinosis is a painful rheumatic condition caused by the deposition of calcium pyrophosphate dihydrate crystals (CPPD) in joint tissues, and especially cartilage. It known that CPPD cause inflammation degenerative changes joint, but underlying mechanisms remain poorly understood. In particular, nothing about how these regulates transmembrane heparan sulphate proteoglycans (HSPGs). Our attention focused on one family HSPGs called syndecans as they have important roles both...
Background: Calcification of cartilage with BCP crystals is a common finding during osteoarthritis (OA) and directly linked to the severity disease hypertrophic differentiation chondrocytes. Chondrocalcinosis (CC) associated CPPD crystal formation. There only little knowledge about effect on Objectives: The aim this study was investigate chondrocyte phenotype in CC Methods: Cartilage samples patients were used compared severe OA without chondrocalcinosis healthy served as control....
<h3>Background</h3> Calcification of cartilage with BCP crystals is a common finding during osteoarthritis (OA) and directly linked to the severity disease hypertrophic differentiation chondrocytes. In some OA samples calcium pyrophosphate dihydrate (CPPD) can be found. The mechanism underlying formation CPPD their effects on chondrocytes are not completely understood. <h3>Objectives</h3> aim this study was evaluate effect compared chondrocyte phenotype in cartilage. <h3>Methods</h3>...