L. Dietrich
A5103074574- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Chemical Synthesis and Analysis
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Particle Detector Development and Performance
- Wnt/β-catenin signaling in development and cancer
- Osteoarthritis Treatment and Mechanisms
- RNA modifications and cancer
- Biopolymer Synthesis and Applications
- Click Chemistry and Applications
- Nuclear reactor physics and engineering
- Microbial Natural Products and Biosynthesis
- DNA and Nucleic Acid Chemistry
- Healthcare and Venom Research
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Plant and fungal interactions
- Cellular transport and secretion
- Particle Accelerators and Free-Electron Lasers
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- Allergic Rhinitis and Sensitization
- Biochemical effects in animals
Heidelberg University
2002-2024
Chemical Genomics Centre
2016-2018
Max Planck Society
2003-2018
Leipzig University
2018
TU Dortmund University
2013-2017
Stony Brook University
2003
Max Planck Innovation
2003
Interactions of long non-coding RNAs (lncRNA) with proteins play important roles in the regulation many cellular processes. PANDAR (Promotor CDKN1A Antisense DNA damage Activated RNA) is a lncRNA that transcribed p53-dependent manner from promoter and involved proliferation senescence. Overexpression has been observed several tumor species correlated poor prognosis for patient survival rate. Depending on state, known to interact such as nuclear transcription factor Y subunit A (NF-YA)...
We report on first measurements of low-mass electron-positron pairs in Pb-Au collisions at the CERN SPS beam energy 40 AGeV. The observed pair yield integrated over range invariant masses 0.2<m</=1 GeV/c(2) is enhanced expectation from neutral meson decays by a factor 5.9+/-1.5(stat)+/-1.2(syst data)+/-1.8(syst decays), somewhat larger than previously higher 158 results are discussed with reference to model calculations based pi(+)pi(-)-->e(+)e(-) annihilation modified rho propagator. They...
We present a measurement of e+e− pair production in central PbAu collisions at 158AGeV/c. As reported earlier, significant excess the yield over expectation from hadron decays is observed. The improved mass resolution data set, recorded with upgraded CERES experiment CERN-SPS, allows for comparison different theoretical approaches. clearly favor substantial in-medium broadening ρ spectral function density-dependent shift pole mass. model implies that baryon induced interactions are key...
Small GTPases comprise a family of highly relevant targets in chemical biology and medicinal chemistry research have been considered "undruggable" due to the persisting lack effective synthetic modulators suitable binding pockets. As molecular switches, small control multitude pivotal cellular functions, their dysregulation is associated with many human diseases such as various forms cancer. Rab-GTPases represent largest subfamily are master regulators vesicular transport interacting...
Macrocyclic peptides can interfere with challenging biomolecular targets including protein-protein interactions. Whereas there are various approaches that facilitate the identification of peptide-derived ligands, their evolution into higher affinity binders remains a major hurdle. We report virtual screen based on molecular docking allows maturation macrocyclic taking non-natural amino acids consideration. These macrocycles bear large and flexible substituents usually complicate use...
Based on an evaluation of data pion interferometry and particle yields at midrapidity, we propose a universal condition for thermal freeze-out pions in heavy-ion collisions. We show that occurs when the mean free path lambda(f) reaches value about 1 fm, which is much smaller than spatial extent system freeze-out. This critical independent centrality collision beam energy from Alternating Gradient Synchrotron to Relativistic Heavy Ion Collider.
We report a measurement of $\phi$ meson production in central Pb+Au collisions at E$_{lab}$/A=158 GeV. For the first time heavy-ion collisions, mesons were reconstructed same experiment both K$^+$K$^-$ and dilepton decay channel. Near mid-rapidity, this yields rapidity densities, corrected for value, 2.05 +- 0.14(stat) 0.25(syst) 2.04 0.49(stat)+-{0.32}(syst), respectively. The shape measured transverse momentum spectra is also close agreement channels. data rule out possible enhancement...
We present results of a two-pion correlation analysis performed with the $\mathrm{Pb}+\mathrm{Au}$ collision data collected by upgraded CERES experiment in fall 2000. The was done bins reaction centrality and pion azimuthal emission angle respect to plane. source, deduced from data, is slightly elongated direction perpendicular plane, similarly as observed at Brookhaven National Laboratory Alternating Gradient Synchrotron Relativistic Heavy Ion Collider.
The Fourier harmonics, $v_2$ and $v_3$ of negative pions are measured at center-of-mass energy per nucleon pair $\sqrt{s_{\mathrm{NN}}}$= 17.3 GeV around midrapidity by the CERES/NA45 experiment CERN SPS in 0--30% central PbAu collisions with a mean centrality 5.5%. analysis is performed two bins as function transverse momentum $\mathrm{p_{\mathrm{T}}}$ from 0.05 GeV/$c$ to more than 2 GeV/$c$. This first measurement $v^{1/3}_{3}/v^{1/2}_{2}$ ratio energies. For above 0.5 GeV/$c$, nearly...
Abstract The Fourier harmonics, $$v_2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>v</mml:mi> <mml:mn>2</mml:mn> </mml:msub> </mml:math> and $$v_3$$ <mml:mn>3</mml:mn> of negative pions are measured at center-of-mass energy per nucleon pair $$\sqrt{s_{\textrm{NN}}}$$ <mml:msqrt> <mml:mi>s</mml:mi> <mml:mtext>NN</mml:mtext> </mml:msqrt> = 17.3 GeV around midrapidity by the CERES/NA45 experiment CERN SPS in 0–30% central PbAu collisions with a mean centrality...
During the 1999 lead run, CERES has measured hadron and electron-pair production at 40 A GeV/c beam momentum with spectrometer upgraded by addition of a radial TPC. Here analysis Λ will be presented.