A5020943640- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Signaling Pathways in Disease
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
University of Münster
2018-2020
Chemical Genomics Centre
2018
Max Planck Society
2018
Interactions of long non-coding RNAs (lncRNA) with proteins play important roles in the regulation many cellular processes. PANDAR (Promotor CDKN1A Antisense DNA damage Activated RNA) is a lncRNA that transcribed p53-dependent manner from promoter and involved proliferation senescence. Overexpression has been observed several tumor species correlated poor prognosis for patient survival rate. Depending on state, known to interact such as nuclear transcription factor Y subunit A (NF-YA)...
The oncogenic transcription factor B-Myb is an essential regulator of late cell cycle genes whose activation by phosphorylation still poorly understood. We describe a stepwise mechanism B-Myb, which involves sequential phosphorylations mediated cyclin-dependent kinase (Cdk) and Polo-like 1 (Plk1) Pin1-facilitated peptidyl-prolyl cis/trans isomerization. Our data suggest model in initial Cdk-dependent enables subsequent Pin1 binding Pin1-induced conformational changes B-Myb. This, turn,...
B-MYB, a highly conserved member of the MYB transcription factor family, is expressed ubiquitously in proliferating cells and plays key roles important cell cycle-related processes, such as control G2/M-phase transcription, cytokinesis, G1/S-phase progression DNA-damage reponse. Deregulation B-MYB function characteristic several types tumor cells, underlining its oncogenic potential. To gain better understanding functions we have employed affinity purification coupled to mass spectrometry...