A5017273356- Microtubule and mitosis dynamics
- Complementary and Alternative Medicine Studies
- Cancer-related Molecular Pathways
- Plant Molecular Biology Research
- Diet and metabolism studies
- Ubiquitin and proteasome pathways
- Photosynthetic Processes and Mechanisms
- Cellular transport and secretion
- Genomics and Chromatin Dynamics
- Micro and Nano Robotics
- Clostridium difficile and Clostridium perfringens research
- Cancer Immunotherapy and Biomarkers
- Urinary Bladder and Prostate Research
- Cancer Cells and Metastasis
- Advanced Neuroimaging Techniques and Applications
- Gut microbiota and health
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Cellular Mechanics and Interactions
- CRISPR and Genetic Engineering
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Cytokine Signaling Pathways and Interactions
- Microscopic Colitis
- Pelvic floor disorders treatments
West Bengal University of Health Sciences
2023
Medical College and Hospital, Kolkata
2023
Sixin (China)
2023
University of Pennsylvania
2007-2022
Albert Einstein College of Medicine
2012-2016
The Wistar Institute
2002
The c-MYC oncoprotein functions as a sequence-specific transcription factor. ability of to activate relies in part on the recruitment cofactor complexes containing histone acetyltransferases mammalian GCN5 (mGCN5)/PCAF and TIP60. In addition acetylating histones, these enzymes have been shown acetylate other proteins involved transcription, including factors. This study was initiated order determine whether is direct substrate mGCN5 We report here that mGCN5/PCAF TIP60 vivo. By using...
Invasive carcinomas survive and evade apoptosis despite the absence of an exogenous basement membrane. How epithelial tumors acquire anchorage independence for survival remains poorly defined. Epithelial often secrete abundant amounts extracellular matrix protein laminin 5 (LM-5) frequently express α6β4 integrin. Here, we show that autocrine LM-5 mediates anchorage-independent in breast through ligation a wild-type, but not cytoplasmic tail–truncated integrin does mediate tumor activation...
The p53 tumor suppressor regulates the cellular response to genetic damage through its function as a sequence-specific transcription factor. Among most well-characterized transcriptional targets of is mdm2 oncogene. Activation critical in pathway because protein marks for proteosome-mediated degradation, thereby providing negative-feedback loop. Here we show that ATM-related TRRAP functionally cooperates with activate transcription. component several multiprotein acetyltransferase complexes...
To elucidate the structural basis of mechanism microtubule depolymerization by kinesin-13s, we analyzed complexes tubulin and Drosophila melanogaster kinesin-13 KLP10A electron microscopy (EM) fluorescence polarization microscopy. We report a nanometer-resolution (1.1 nm) cryo-EM three-dimensional structure head domain (KLP10AHD) bound to curved tubulin. found that binding KLP10AHD induces distinct configuration with displacement (shear) between subunits in addition curvature. In this...
During spermatogenesis, cells coordinate differentiation with the meiotic cell cycle to generate functional gametes. We identified a novel gene, which we named off-schedule (ofs), as being essential for this coordinated control. G(2) phase, Drosophila ofs mutant germ do not reach their proper size and fail execute meiosis or significant differentiation. The accumulation of four regulators--Cyclin A, Boule, Twine Roughex--is altered in these mutants, indicating that reveals branch pathway...
This study aimed at examining the feasibility issues of comparing individualized homeopathic medicines (IHMs) with identical-looking placebos for treating knee osteoarthritis (OA).