A5019460244- Gut microbiota and health
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Celiac Disease Research and Management
- Reproductive Biology and Fertility
- Dietary Effects on Health
- Diet, Metabolism, and Disease
- Assisted Reproductive Technology and Twin Pregnancy
- FOXO transcription factor regulation
- Nutritional Studies and Diet
- Probiotics and Fermented Foods
- Gastroesophageal reflux and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Diverticular Disease and Complications
- Alcohol Consumption and Health Effects
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Viral gastroenteritis research and epidemiology
- Clinical Nutrition and Gastroenterology
- Pregnancy and preeclampsia studies
Associated Research (United States)
2021-2025
Cedars-Sinai Medical Center
2015-2024
University of Exeter
2024
Association on Higher Education And Disability
2016
Motility (United States)
2011-2012
New South Wales Department of Health
2010
Menzies School of Health Research
2010
Government of Western Australia Department of Health
2010
Minehead Community Hospital
2005
University of Tennessee at Knoxville
1954
Down syndrome (DS), or trisomy 21, is a common disorder associated with several complex clinical phenotypes. Although hypotheses have been put forward, it unclear as to whether particular gene loci on chromosome 21 (HSA21) are sufficient cause DS and its features. Here we present high-resolution genetic map of phenotypes based an analysis 30 subjects carrying rare segmental trisomies various regions HSA21. By using state-of-the-art genomics technologies mapped at exon-level resolution...
Gut microbial diversity decreases with aging, but existing studies have used stool samples, which do not represent the entire gut. We analyzed duodenal microbiome in 251 subjects aged 18-35 (n = 32), 36-50 41), 51-65 96), and 66-80 82). Decreased older is associated combinations of chronological age, number concomitant diseases, medications used, also correlated increasing coliform numbers (p < 0.0001). Relative abundance (RA) phylum Proteobacteria increases subjects, increased RA family...
INTRODUCTION: Irritable bowel syndrome (IBS) includes diarrhea-predominant (IBS-D) and constipation-predominant (IBS-C) subtypes. We combined breath testing stool microbiome sequencing to identify potential microbial drivers of IBS METHODS: IBS-C IBS-D subjects from 2 randomized controlled trials (NCT03763175 NCT04557215) were included. Baseline carbon dioxide, hydrogen (H ), methane (CH 4 sulfide S) levels measured by gas chromatography, baseline composition was analyzed 16S rRNA...
Diarrhea-predominant irritable bowel syndrome (IBS) is diagnosed through clinical criteria after excluding "organic" conditions, and can be precipitated by acute gastroenteritis. Cytolethal distending toxin B (CdtB) produced bacteria that cause gastroenteritis, a post-infectious animal model demonstrates host antibodies to CdtB cross-react with vinculin in the gut, producing an IBS-like phenotype. Therefore, we assessed circulating anti-CdtB anti-vinculin as biomarkers for D-IBS human...
Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, breath methane is associated a greater body mass index (BMI) among obese human subjects.The objective study was to characterize relationship between hydrogen on test (as surrogate for colonization requiring methanogen, Methanobrevibacter smithii), weight, percent fat general population cohort.This prospective (n = 792) consecutive subjects...
Objective. Breath testing and duodenal culture studies suggest that a significant proportion of irritable bowel syndrome (IBS) patients have small intestinal bacterial overgrowth. In this study, we extended these data through 16S rDNA amplicon sequencing quantitative PCR (qPCR) analyses aspirates from large cohort IBS, non-IBS control subjects. Materials methods. Consecutive subjects presenting for esophagogastroduodenoscopy only healthy controls were recruited. Exclusion criteria included...
Most gut microbiome studies have been performed using stool samples. However, the small intestine is of central importance to digestion, nutrient absorption, and immune function, characterizing its microbial populations essential for elucidating their roles in human health disease.To characterize different intestinal segments contrast these microbiome.Male female subjects undergoing esophagogastroduodenoscopy without colon preparation were prospectively recruited. Luminal aspirates obtained...
Small intestinal bacterial overgrowth (SIBO) is highly prevalent and associated with numerous gastrointestinal disorders, but the microbes involved remain poorly defined. Moreover, existing studies of microbiome alterations in SIBO have utilized stool samples, which are not representative entire tract. Therefore, we aimed to determine compare duodenal composition non-SIBO subjects, using aspirates from subjects undergoing standard-of-care esophagogastroduodenoscopy without colon preparation....
This cross-sectional study investigates the association between glucagon-like peptide-1 receptor agonists and food retention during esophagogastroduodenoscopy.
Elemental diets (EDs) have desirable safety and efficacy profiles in several clinical settings partly due to modulation of gut microbiome. Palatability EDs remains the main barrier compliance/adherence, their effect has not been prospectively explored microbiome-driven disorders such as small intestinal bacterial overgrowth (SIBO) methanogen (IMO). We aimed assess effect, tolerance, a novel palatable ED (PED) subjects with IMO and/or SIBO. Adult positive lactulose breath tests (LBT) for SIBO...
Gut microbiome changes are linked to obesity, but findings based on stool data. In this article, we analyzed the duodenal and serum biomarkers in subjects with normal weight, overweight, obesity.
Abstract It is increasingly understood that gastrointestinal (GI) methanogens, including Methanobrevibacter smithii, influence host metabolism. Objective: Therefore, we compared M. smithii colonization and weight gain in a rat model under different dietary conditions. Design Methods: Sprague‐Dawley rats were inoculated with or vehicle ( N = 10/group), fed normal chow until day 112 postinoculation, high‐fat 182, then 253. Thereafter, five from each group euthanasia. Results: Both groups...
Campylobacter jejuni infection is a leading cause of acute gastroenteritis, which trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) expressed by enteric pathogens that PI-IBS. We used rat model PI-IBS to investigate the role CDT in long-term altered stool form and phenotypes.
Abstract Background The human small intestine plays a central role in the processes of digestion and nutrient absorption. However, characterizations gut microbiome have largely relied on stool samples, associated methodologies are ill-suited for viscosity low microbial biomass samples. As part REIMAGINE study to examine specific roles bowel health disease, this aimed develop validate optimize analysis intestine. Results Subjects undergoing esophagogastroduodenoscopy without colon preparation...