Cadmium (Cd 2+ ), a naturally occurring heavy metal, is an important environmental pollutant and potent toxicant to bacteria. The gastrointestinal (GI) tract microflora has marked capacity cope with the increased load of ingested metals. However, metals may have harmful effects on GIT microflora. Under conditions experimental exposure cadmium, changes in population intestinal healthy mice were examined. Five groups received 23 50 mg kg -1 cadmium drinking water control group was given free...

Abstract In this research, the hydrophilic structure of multi-walled carbon nanotubes (MWCNTs) was modified by synthesizing polycitric acid (PCA) and attaching folic (FA) to create MWCNT–PCA–FA. This nanocomplex utilized as a carrier for lipophilic compound curcumin (Cur). Characterization techniques including TGA, TEM, UV–visible spectrophotometry were used analyze nanocomplex. The mechanism cancer cell death induced MWCNT–PCA–FA studied extensively using MTT assay, colony formation...

Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is pentacyclic terpenoid that active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative Crohn's disease, and memory impairment, but mechanism poorly understood. This study investigated effects boswellic on spatial learning impairment induced by trimethyltin (TMT) in Wistar rats.Forty male rats were randomly divided into 5 groups: Normal group, TMT-administrated (8.0...

Abstract Objectives Synthesizing and characterization of gold nanoparticles (Au NPs) by Ferula persica gum essential oil investigating in vitro anti-cancer effects. Methods Characterization NPs was performed. Cytotoxicity apoptosis were determined on cancerous CT26 non-cancerous Vero cells using MTT assay acridine orange/ethidium bromide (AO/EB) staining, respectively. Clonogenic also Key findings The absorption peak UV-visible spectroscopy at 530 nm. In TEM image, Au spherical shape with...

Background: Haloxylon ammodendron belongs to the genus of Amaranthaceae family. This study is first assess antibacterial and antifungal properties H. ethanolic extract provides an analysis plant’s antioxidant capacity. Additionally, research offers insights into phenolic content extract, which directly linked its bioactivity. Objectives: The aimed evaluate antioxidant, antibacterial, activity determine extract. Methods: maceration method was used prepare this investigated using two strains...

• The total phenolic contents of ethanolic extract propolis and honey samples were determined. affect wound healing, rate cell migration, viability, proliferation human dermal fibroblast cells dose-dependently. had no synergistic effects. Propolis are two apiculture products with various pharmacological biological properties that have been recognized since ancient times. present investigation was an in vitro analysis the impacts individual concomitant application Iranian on process healing....

The emergence of antibacterial resistance against several classes antibiotics is an inevitable consequence drug overuse. As antimicrobial spreads throughout the globe, new substances will always be necessary to fight multidrug-resistant microorganisms. Venoms many animals have recently gained attention in search for antimicrobials treat infectious diseases. Thefore, present study aimed effects wasp (Vespa orientalis) crude venom. Two gram-positive bacteria (Staphylococcus aureus and Bacillus...

The development of novel antimicrobial strategies is necessary because the escalation multidrug‐resistant pathogens. Recently, peptides and their combination with nanoparticles were regarded as a promising tool to target drug‐resistant Herein, we evaluated efficacy peptide extracted from Vespa orientalis wasp venom also its conjugation gold nanoparticles. Nanoparticle measurement was done by evaluating absorbance changes surface plasmon resonance band at 555 nm. A significant increase in...

Mesenchymal stem cells (MSCs) can modulate dendritic (DCs) activation and induce tolerogenic characteristics in DCs. All mechanisms involved MSCs-induced DCs are not fully understood. MicroRNAs (miRs) play important role maturation function of In this study, we investigated the effects MSCs culture supernatant (C.S.) on expression miR-155 miR-23b mice BALB/c spleens were used for isolation. isolated from bone marrow cultured DMEM media. When expanded to sixth passage, C.S. was collected...

Background: Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. Objective: To investigate the therapeutic effects DMF on histological functional recovery rats after transient middle cerebral artery (MC A) occlusion. Methods: 22 Sprague-Dawley male weighing 275–300 g were randomized into three groups by block randomization. In sham group (n = 7), neck was opened, but neither MCA occluded, nor any drug...

Currently, the use of 'green' synthesised nanoparticles with environmentally friendly properties is considered a novel therapeutic approach in medicine. Here, authors evaluated gold (AuNPs) conjugated Tragopogon dubius leaf extract and their antibacterial activity vitro vivo. Colour changes from yellow to dark brown peak at 560 nm on ultraviolet-visible spectroscopy confirmed formation nanoparticles. Additionally, transmission electron microscopy, X-ray diffraction, Fourier transform...

Objective: Recently, many researches with different viewpoints have focused on application of immunotherapy agents in treatment spinal cord injury (SCI) according to neuroprotective results some neurodegenerative disease. Glatiramer acetate (GA) is the most commonly used drug for Multiple sclerosis (MS) patients that exerts an immunomodulatory effect against Myelin basic protein (MBP) antigen. Materials and methods: High-dose (2mg/kg) GA 28 consecutive days after SCI was compared its...

In this study, murine colon carcinoma (CT26) as well non-cancerous Vero cells were exposed to various concentrations of essential oil (EO) obtained from the gum F. persica (0.125 × 10−9 20 µl/ml and 0.125 80 µl/ml, respectively) for 24 h. The cytotoxicity apoptosis determined using MTT assay acridine orange/ethidium bromide (AO/EB) staining, respectively. Clonogenic was also performed. Among 28 compounds that by GC/MS, major constituent EO α-pinene (27.1%). A dose-dependent observed on CT26...

Nitrofurantoin is a nitroaromatic compound used for the treatment of urinary tract infections. activity regulated by nitroreduction process. It first reduced bacterial nitroreductases to active short-life intermediates, which are further converted non-toxic molecules, negatively affect its antibacterial activity. In this study we have shown that resistant strains Klebsiella sp. inactivate bactericidal nitrofurantoin. Also demonstrated synergistic effect between menthol and nitrofurantoin...

GABA can influence the steroidogenesis in peripheral and central nervoussystems.The present study investigates interactive effect of GABAA receptors extremely low frequency electromagnetic field on serum testosterone level male rats.Fifty adult rats were randomly assigned into 10 groups. Groups 2, 4, 6, 8, exposed to ELF-EMF for 30 days 8hrs per day; while, remaining groups (1, 3, 5, 7, 9) sham animals. At end experiment, animals 1 2 received normal saline; 3 4 treated with mg/kg bicuculline...