A5032072669- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Advanced materials and composites
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Intermetallics and Advanced Alloy Properties
- Metal and Thin Film Mechanics
- Tryptophan and brain disorders
- Cognitive Abilities and Testing
- Treatment of Major Depression
- High Entropy Alloys Studies
- Sleep and related disorders
- Stroke Rehabilitation and Recovery
- Neuroendocrine Tumor Research Advances
- Mechanical Circulatory Support Devices
- Plant-based Medicinal Research
- Stress Responses and Cortisol
- RNA Interference and Gene Delivery
- Vitamin D Research Studies
- Receptor Mechanisms and Signaling
- Heart Failure Treatment and Management
Children's Nutrition Research Center at Baylor College of Medicine
2016-2023
Central South University
2010-2023
Zhejiang University
2014-2020
Hangzhou First People's Hospital
2013-2020
Baylor College of Medicine
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Beijing Shijingshan Hospital
2014
Shandong Mental Health Center
2008
Significance The therapeutic potential of protein-based genome editing is dependent on the delivery proteins to appropriate intracellular targets. Here we report that combining bioreducible lipid nanoparticles and negatively supercharged Cre recombinase or anionic Cas9:single-guide (sg)RNA complexes drives self-assembly for potent protein editing. design lipids facilitates degradation inside cells in response reductive environment, enhancing endosome escape protein. In addition, modulation...
Abstract The high comorbidity between obesity and mental disorders, such as depression anxiety, often exacerbates metabolic neurological symptoms significantly. However, neural mechanisms that underlie reciprocal control of feeding states are largely elusive. Here we report melanocortin 4 receptor (MC4R) neurons located in the dorsal bed nucleus stria terminus (dBNST) engage regulation mentally associated weight gain by receiving GABAergic projections from hypothalamic AgRP onto...
Contrasting to the established role of hypothalamic agouti-related protein (AgRP) neurons in feeding regulation, neural circuit and signaling mechanisms by which they control energy expenditure remains unclear. Here, we report that is regulated a subgroup AgRP send non-collateral projections within dorsal lateral part raphe nucleus (dlDRN) expressing melanocortin 4 receptor (MC4R), turn innervate nearby serotonergic (5-HT) neurons. Genetic manipulations reveal bi-directional this without...
Significance We established a new genetic method for rapidly activating Cre recombinase that is based on suppression of nonsense codon within by generation aminoglycosides. applied this strategy to successfully silence both enzymes responsible GABA biosynthesis in hypothalamic agouti-related peptide (AgRP) neurons control appetite and other behaviors. Inactivation signaling AgRP young adult mice resulted severe loss body weight abnormal glucose metabolism, whereas older only manifested...
A dopaminergic neural circuit projecting from the VTA to hindbrain regulates feeding by transducing meal satiation signals.
The hormone leptin is known to robustly suppress food intake by acting upon the receptor (LepR) signaling system residing within agouti-related protein (AgRP) neurons of hypothalamus. However, clinical studies indicate that undesirable as a therapeutic regiment for obesity, which at least partly attributed poorly understood complex secondary structure and key mechanism leptin-responsive neural circuit. Here, we show LepR-expressing portal send GABAergic projections cohort α3-GABAA expressing...
The basal forebrain (BF) plays a crucial role in cortical activation. Our previous study showed that activation of cholinergic BF neurons alone is sufficient to suppress slow-wave sleep (SWS) and promote wakefulness rapid-eye-movement (REM) sleep. However, the exact silencing sleep-wake cycle remains unclear. We inhibitied genetically targeted with archaerhodopsin (Arch) yellow light clarify cycle. Bilateral inactivation prolonged SWS decreased probability awakening from mice. these changed...
Although extensively studied, the exact role of sleep in learning and memory is still not very clear. Sleep deprivation has been most frequently used to explore effects on memory, but results from such studies are inevitably complicated by concurrent stress distress. Furthermore, it clear whether there a strict time-window between consolidation. In present study we were able induce time-locked slow-wave (SWS) mice optogenetically stimulating GABAergic neurons parafacial zone (PZ), providing...
Obese subjects often exhibit hypersomnia accompanied by severe sleep fragmentation, while emerging evidence suggests that poor quality promotes overeating and exacerbates diet-induced obesity (DIO). However, the neural circuit signaling mechanism underlying reciprocal control of appetite is yet not elucidated. Here, we report a where prokineticin receptor 2 (PROKR2)-expressing neurons within parabrachial nucleus (PBN) brainstem received direct projections from neuropeptide Y Y2...
A new kind of Nb-W-C alloy with special microstructure and excellent mechanical property was designed prepared by CVD subsequent homogenizing heat treatment. Its is composed columnar crystals specific orientation, neddle-like Nb2C second phase layered structure Nb/W composition segregation. By analyzing the effect treatment on alloy, it found that as-deposited retained in after at 1400 °C, but disappeared treated 1600 °C. The can effectively separate inhibit size coarsening during carbide...
Objective To explore the correlation between depression status of patients with post-stroke depression(PSD) and nerve function defect.Methods 75 in first 24h acute stroke onset were selected.According to Zung self rating scale(SDS),75 cases divided into simple group PSD group,and Hamilton scale (HAMD) Scandinavian defect (SSS) used for further evaluation.The score results statistically analyzed.Results Of stroke,32 cases(42.7％) diagnosed PSD.Admission day 2,at end 1,2 3 weeks,the HAMD scores...
Combining high strength and good ductility is an urgent requirement for refractory entropy alloys (RHEAs), but yet a challenge. Here, we designed successfully developed novel MoTaVW RHEAs with excellent ductility. The phase composition, microstructure, mechanical properties, strengthening deformation mechanism were studied analyzed in depth, respectively. Different from other few phases, RHEA contains three phases (Ta-rich, Mo-rich V-rich phase) different composition differences at low...