A5033514231- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Viral Infections and Immunology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- Gestational Diabetes Research and Management
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Amino Acid Enzymes and Metabolism
- Birth, Development, and Health
- Lung Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Hemoglobinopathies and Related Disorders
- Pancreatic and Hepatic Oncology Research
- Antioxidant Activity and Oxidative Stress
- Folate and B Vitamins Research
- Redox biology and oxidative stress
Suizhou Central Hospital
2023
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2022
Jiangsu University
2019
Affiliated Hospital of Jiangsu University
2019
Hubei University of Medicine
2018
Guangdong Medical College
2015-2017
Abstract Background The pathogenic mechanism of dilated cardiomyopathy (DCM) remains to be defined. This study aimed identify hub genes and immune cells that could serve as potential therapeutic targets for DCM. Methods We downloaded four datasets from the Gene Expression Omnibus (GEO) database: GSE141910, GSE3585, GSE42955 GSE79962. Weighted gene coexpression network analysis (WGCNA) differential expression were performed panels related Meanwhile, CIBERSORT algorithm was used estimate in...
Background. Antioxidants attracted long-standing attention as promising preventive agents worldwide. Previous observational studies have reported that circulating antioxidants are associated with reduced mortality; however, randomized clinical trials indicate neutral or harmful impacts. The association of long-term antioxidant exposure longevity is still unclear. Objectives. We aim to determine whether causally in the general population using two-sample Mendelian randomization (MR) design....
The aim of this study was to investigate the levels thyroid hormone and antithyroid antibodies their relationship with pregnancy outcome in patients gestational diabetes mellitus (GDM) diabetic patients.Fifty GDM 50 pregnant were selected. Their fasting blood glucose (FBG), glycosylated hemoglobin, FT3, FT4, TGab, TSH, TPOab measured until parturition.There no statistically significant differences age, weight, FBG hemoglobin between two groups (P>0.05). FT3 FT4 significantly lower than those...
The importance of cell pyroptosis in immunity regulation is becoming increasingly obvious, especially diseases the cardiovascular system. Nevertheless, it unknown whether signalling pathway involved immune microenvironment dilated cardiomyopathy (DCM). Therefore, purpose study was to investigate influence on environment cardiomyopathy. We found that expression 19 pyrolysis-related genes (PRGs) DCM samples altered compared healthy samples. Subsequently, based these 12 hub genes, we developed...
The metastasis of liver cancer is a major cause clinical treatment failure, restrain, and control the strategy prevention disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors considered as potential target anticancer drug. This study investigated mechanism how ganodermanontriol effect expression SATB1 thus inhibits growth hepatocellular carcinoma (HCC).This explored mainly on affects proliferation tumor human hepatoma cell line HepG2.The...
The association between systemic iron status and lung function was conflicting in observational studies. We aim to explore the potential causal relationships levels of using two-sample Mendelian randomization (MR) design.Genetic instruments associated with biomarkers were retrieved from Genetics Iron Status (GIS) consortium (N = 48,972). Summary statistics these genetic extracted a meta-analysis UK Biobank SpiroMeta 400,102). main analyses performed inverse-variance weighted method,...
Long non-coding RNAs(lncRNAs)are a group of none protein coding regulatory RNAs in the cells. They have length longer than 200 nucleotides general and regulate expression transcripts. Studies demonstrated that lncRNAs can control gene through epigenetic regulation, transcription regulation post-transcription regulation. LncRNAs might be involved islet beta-cell differentiation, insulin secretion sugar lipid metabolism, which association with development progression diabetes. This review...
Protein phosphatase 2A (PP2A) is one of the most common serine/threonine phosphatases in mammalian cells, and it primarily functions to regulate cell signaling, glycolipid metabolism apoptosis. The catalytic subunit PP2A (PP2Ac) plays an important role protein. However, there are few reports on regulatory PP2Ac pancreatic β-cells under lipotoxic conditions. In present study, mouse insulinoma 6 (MIN6) cells were transfected with short hairpin RNAs generate knockdown incubated palmitate (PA)...
Abstract Background: The pathogenic mechanism of Dilated Cardiomyopathy (DCM) remain to be defined. This study aimed identify hub genes and immune cells that could serve as potential therapeutic targets for DCM. Methods: We downloaded four data sets from the Gene Expression Omnibus (GEO) database, GSE141910, GSE3585, GSE42955 GSE79962. Weighted gene coexpression network analysis (WGCNA) differential expression were performed identified panel related Meanwhile, CIBERSORT algorithm was used...