A5036601178- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Muscle activation and electromyography studies
- Nerve injury and regeneration
- Silk-based biomaterials and applications
- Calpain Protease Function and Regulation
- Musicology and Musical Analysis
- Sirtuins and Resveratrol in Medicine
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Advanced Sensor and Energy Harvesting Materials
- Neurogenetic and Muscular Disorders Research
- Signaling Pathways in Disease
- Cardiomyopathy and Myosin Studies
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Genetic Neurodegenerative Diseases
- Sports Performance and Training
- Medication Adherence and Compliance
- Cardiac Fibrosis and Remodeling
- Nuclear Structure and Function
- Telomeres, Telomerase, and Senescence
- Sports injuries and prevention
- Plant biochemistry and biosynthesis
Université de Montpellier
2006-2025
Inserm
2012-2025
Centre National de la Recherche Scientifique
2003-2025
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2010-2024
Novartis (France)
2023-2024
Nagasaki University
2011
Hôpital Arnaud de Villeneuve
2005-2010
Institut Bouisson Bertrand
2001-2003
Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD), particularly after exacerbations. We thus asked whether neuromuscular electrostimulation (NMES) might be directly useful following an acute exacerbation and if such therapy decreases muscular oxidative stress and/or alters muscle fibre distribution. A pilot randomised controlled study of NMES lasting 6 weeks was carried out 15 in-patients (n=9 NMES; n=6 sham) COPD exacerbation. Stimulation delivered to the...
The present study investigated whether muscular monocarboxylate transporter (MCT) 1 and 4 contents are related to the blood lactate removal after supramaximal exercise, fatigue indexes measured during different exercises, muscle oxidative parameters in 15 humans with training status. Lactate recovery curves were obtained a 1-min all-out exercise. A biexponential time function was then used determine velocity constant of slow phase (γ 2 ), which denoted ability. Fatigue calculated (FI AO )...
Background Contrary to adaptive support ventilation (ASV), prolonged totally controlled mechanical (CMV) results in the absence of diaphragm activity and causes ventilator-induced diaphragmatic dysfunction. Because maintaining respiratory muscles at rest is likely a major cause dysfunction, ASV may prevent its occurrence comparison with CMV. The aim our study was compare effects those CMV on both vivo vitro properties. Methods Two groups six anesthetized piglets were ventilated during 72-h...
Summary Protection of satellite cells from cytotoxic damages is crucial to ensure efficient adult skeletal muscle regeneration and improve therapeutic efficacy cell transplantation in degenerative diseases. It therefore important identify characterize molecules their target genes that control the viability stem cells. Recently, we demonstrated high aldehyde dehydrogenase activity associated with increased human myoblasts. In addition its detoxifying activity, can also catalyze irreversible...
In the neuromuscular system, signal transmission from motor neurons (MNs) to innervated muscle fibers is crucial for their synaptic function, viability, and maintenance. order better understand human junction (hNMJ) functionality, it important develop on-a-chip devices with cells. To investigate this cell network, microfluidic platforms are useful grow different types in isolated compartments. Such have already been developed study vitro neuronal circuitry. Here, we combined microfluidics...
Inter-individual variability in muscle responses to mechanical stress during exercise is poorly understood. Therefore, new cell culture scaffolds are needed gain deeper insights into the cellular mechanisms underlying influence of on human myogenic progenitor cells behavior. To this end, we propose first vitro model involving uniaxial applied aligned primary muscle-derived cells, employing a biocompatible organic-inorganic photostructurable hybrid material (OIPHM) covalently attached...
The localization of dystrophin at the sarcolemma cardiac skeletal fibers and Purkinje has been described. Dystrophin deficiency produces clinical manifestations disease in muscles hearts patients with Duchenne Becker muscular dystrophy. Utrophin (or dystrophin-related protein), a homologous protein, was found to be expressed fetal reexpressed dystrophin-deficient muscle fibers. We therefore examined utrophin expression normal hearts.The subcellular distribution by immunoblot...
The Duchenne muscular dystrophy gene gives rise to transcripts of several lengths. These mRNAs differ in their coding content and tissue distribution. 14 kb mRNA encodes dystrophin, a 427 kDa protein found muscle brain, the short described encode DP71, 77 various organs. have many features common deduced primary structure especially cysteine-rich specific C-terminal domains. dystrophin domain could be involved membrane anchorage via glycoprotein complex, but such functional role for these...
E2F1 deletion leads to increased mitochondrial number and function, body temperature in response cold resistance fatigue with exercise. Since E2f1−/− mice show muscle performance, we examined the effect of E2f1 genetic inactivation mdx background, a mouse model Duchenne muscular dystrophy (DMD). E2f1−/−;mdx demonstrated strong reduction physiopathological signs DMD, including preservation structure, decreased inflammatory profile, utrophin expression, resulting better endurance contractile...
Dystrophin forms part of a vital link between actin cytoskeleton and extracellular matrix via the transmembrane adhesion receptor dystroglycan. its autosomal homologue utrophin interact with beta-dystroglycan their highly conserved C-terminal cysteine-rich regions, comprising WW domain (protein-protein interaction containing two tryptophan residues), EF hand ZZ domains. The region stabilizes providing main site dystrophin or domain, predicted zinc finger motif, domains strengthens overall...
Monoclonal antibodies used to distinguish between dystrophin and utrophin were systematically applied skeletal muscles containing arteries veins. Small found contain long forms of both dystrophin, while small veins contained only utrophin. In addition, all sizes vascular smooth demonstrated another related M r 80 kDa protein (possibly a short transcript). Regardless their tissue distributions, we assumed that each these molecules had distinct properties, i.e. with mechanical function an...
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting following repeated damage and inadequate regeneration. Impaired myogenesis differentiation play a major role in DMD as well intracellular calcium (Ca2+) mishandling. Ca2+ release from the sarcoplasmic reticulum mostly mediated type 1 ryanodine receptor (RYR1) that required for skeletal animals. The study objective was to determine whether altered RYR1-mediated contributes myogenic impairment patients. comparison...