A5089103483- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Neural dynamics and brain function
- Metabolism, Diabetes, and Cancer
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Gastroesophageal reflux and treatments
- IoT and Edge/Fog Computing
- Clinical Nutrition and Gastroenterology
- Nutritional Studies and Diet
- Pancreatic function and diabetes
- Cerebrovascular and Carotid Artery Diseases
- Fatty Acid Research and Health
- Digestive system and related health
- Dementia and Cognitive Impairment Research
- Diabetes Management and Research
- Artificial Intelligence in Healthcare
- Antioxidant Activity and Oxidative Stress
- Renin-Angiotensin System Studies
- Protein Kinase Regulation and GTPase Signaling
Health and Social Services Centre University Institute of Geriatrics of Sherbrooke
2017-2024
Université de Sherbrooke
2015-2023
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2019-2022
Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
2016-2019
Centre Hospitalier Universitaire de Sherbrooke
2019
Institute on Aging
2016
We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's disease (AD) requires closer attention in the development AD therapeutics. Our rationale fourfold: (i) Glucose uptake lower frontal cortex people >65 years-old despite cognitive scores are normal for age. (ii) The regional glucose present adults <40 who have genetic or lifestyle risk factors but whom decline has not yet started. Examples include young adult carriers presenilin-1 apolipoprotein E4, and...
Abstract Introduction Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition MCI by providing brain with more fuel. Methods Fifty‐two subjects were blindly randomized to 30 g/day kMCT or matching placebo. Brain ketone and glucose metabolism (quantified positron emission tomography; primary outcome) performance (secondary assessed at baseline 6 months...
Background: Medium chain triglycerides (MCT) are ketogenic but the relationship between change in plasma ketones and medium fatty acids (MCFA) - octanoate, decanoate, or dodecanoate – after an oral dose of MCT is not well-known. An 8 hour metabolic study day a suitable model to assess acute effects on MCFA tricaprylin (C8), tricaprin (C10), trilaurin (C12) mixed (C8C10). Objective: To healthy humans ketones, decanoate total lipids during which first 20 ml homogenized test oil taken with...
Ketones are the brain's main alternative fuel to glucose. Dietary medium-chain triglyceride (MCT) supplements increase plasma ketones, but their ketogenic efficacy relative coconut oil (CO) is not clear.
Ketones provide an alternative brain fuel and may be neuroprotective in older people. Little is known of how to optimize the ketogenic effect C8:0-C10:0 medium chain triglyceride supplement (kMCT). Metabolic switching (MS) from glucose ketones as a have metabolic benefits but has not been extensively studied humans. The objective present study was use 8 h day protocol assess influence typical components MS, including kMCT supplement, low-carbohydrate meal timing, on blood ketones, glucose,...
We aimed to longitudinally assess the relationship between changing brain energy metabolism (glucose and acetoacetate) cognition during healthy aging. Participants aged 71 ± 5 year underwent cognitive evaluation quantitative positron emission tomography (PET) magnetic resonance imaging (MRI) scans at baseline (N = 25) two four 16) years later. During follow-up, rate constant for extraction of glucose (Kglc) declined by 6%-12% mainly in temporo-parietal lobes cingulate gyri (p ≤ 0.05),...
Lower-brain glucose uptake is commonly present before the onset of cognitive deterioration associated with aging and may increase risk Alzheimer disease. Ketones are brain's main alternative energy substrate to glucose. Medium-chain triglycerides (MCTs) rapidly β-oxidized ketogenic but also have gastrointestinal side effects. We assessed whether MCT emulsification into a lactose-free skim-milk matrix [emulsified MCTs (MCT-Es)] would improve ketogenesis, reduce effects, or both compared same...
Ketones, the brain's alternative fuel to glucose, bypass brain glucose deficit and improve cognition in mild cognitive impairment (MCI). Our goal was assess impact of a 6-month ketogenic intervention on functional connectivity within eight major resting-state networks, its possible relationship improved outcomes BENEFIC trial. MCI participants were randomized placebo (n = 15) or medium chain triglyceride (kMCT; n 17) intervention. kMCT associated with increased dorsal attention network...
The octapeptide angiotensin II (AngII) exerts a variety of cardiovascular effects through the activation AngII type 1 receptor (AT<sub>1</sub>), G protein–coupled receptor. AT<sub>1</sub> engages and activates several signaling pathways, including heterotrimeric proteins G<sub>q</sub> G<sub>12</sub>, as well extracellular signal–regulated kinases (ERK) 1/2 pathway. Additionally, following stimulation, <i>β</i>arrestin is recruited to receptor, leading desensitization. It increasingly...
Brain glucose uptake declines during aging and is significantly impaired in Alzheimer's disease. Ketones are the main alternative brain fuel to so they represent a potential approach compensate for reduction. Caffeine of interest as ketogenic agent owing its actions on lipolysis lipid oxidation but whether it humans unknown. This study aimed evaluate acute effect 2 doses caffeine (2.5; 5.0 mg/kg) 10 healthy adults. given at breakfast stimulated ketone production dose-dependent manner (+88%;...
The heart and kidney have a high energy requirement, but relatively little is known about their utilization of ketones as potential source. We assessed the metabolism ketone tracer, carbon-11 acetoacetate ( 11 C-AcAc), by left right ventricles using positron emission tomography (PET) in n = 10 healthy adults under four experimental conditions: 4-h fast (fasted) ± single 12 g oral dose D-beta-hydroxybutyrate (D-BHB), complete, liquid replacement meal (hereafter referred to “fed” condition)...
The objectives of this study were to determine (i) whether a 5-day aerobic exercise (AE) program combined with medium-chain triglyceride (MCT) supplement would increase the plasma ketone response in older women more than either intervention alone and (ii) ketonemia after these or separate treatments was alike normoglycemic (NG) prediabetic (PD) women. Older (NG, n = 10; PD, 9) underwent 4-h metabolic each 4 different treatments: no treatment (control), 5 days MCT (30 g·day −1 ), (iii) 1...
Ketones are alternative energy substrates for the heart and kidney but no studies have investigated their metabolism simultaneously in both organs humans. The present double tracer positron emission tomography (PET) study evaluated organ distribution basal kinetic rates of radiolabeled ketone, 11 C-acetoacetate ( C-AcAc), compared to C-acetate C-Ac), which is a well-validated metabolic radiotracer. Both tracers were highly metabolized by left ventricle renal cortex. In heart, similar...
Poor glucose regulation associated with gradual insulin resistance is a significant risk factor in several age-related chronic diseases. An eating plan that promotes lower carbohydrate intake may have beneficial effect on metabolism. This study aimed to evaluate how diet reduced by 32% (RCHO) over 2 month period would influence the metabolic profile of older individuals (
Brain energy metabolism in Alzheimer’s disease (AD) is characterized mainly by temporo-parietal glucose hypometabolism. This pattern has been widely viewed as a consequence of the disease, i.e. deteriorating neuronal function leading to lower demand for glucose. review will address problem specific and one that precedes AD. Hence, ketones medium chain fatty acids (MCFA) could be an alternative source aging brain compensate low uptake. MCFA form dietary triglycerides (MCT) have long history...
Abstract Background Ketones, the brain’s alternative fuel to glucose, bypass brain glucose deficit in mild cognitive impairment (MCI). The BENEFIC trial conducted MCI showed improved measures of cognition multiple domains after a 6‐month ketogenic intervention [Fortier et al . 2019]. Functional connectivity dorsal‐attention network (DAN) deteriorates early MCI, and prior changes ventral‐attention [Zhang 2015]. We aimed assess whether outcomes Trial were linked functional connectivity. Method...
Blood glucose level monitoring is of great importance, especially for subjects experiencing type 1 diabetes. Accurate their blood prevents dangerous and life-threatening situations that might be experienced by those subjects. In addition, precise levels over long periods time helps establishing knowledge about the daily mealtime routine which aids medical staff to monitor properly intervene in hazardous cases such as hypo- or hyperglycemia. Establishing will play a potential role when...