A5030636600- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Genomic variations and chromosomal abnormalities
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- RNA modifications and cancer
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Advances in Oncology and Radiotherapy
- CRISPR and Genetic Engineering
University of Michigan
2022-2025
Sechenov University
2023
Royal College of Surgeons in Ireland
2023
Poznan University of Medical Sciences
2023
Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects the ETV6 transcriptional repressor, including ETV6-RUNX1+ and ETV6-null B-ALL. show that repeat are direct activators previously identified ETV6-RUNX1+/- like B-ALL "signature" genes, likely leukemogenic driver EPOR. When restored to...
Abstract High expression of MYC and its target genes identify germinal center B-cell diffuse large lymphomas (GCB-DLBCL) associated with poor outcomes. We used CRISPR-interference profiling human lymphoma cell lines to define essential enhancers in the locus non-immunoglobulin rearrangement partner loci, including a recurrent between BCL6 control region. GCB-DLBCL without are dependent on an evolutionarily-conserved enhancer we name “germinal 1” (GME-1), which is activated by transcription...
High expression of MYC and its target genes define a subset germinal center B-cell diffuse large lymphoma (GCB-DLBCL) associated with poor outcomes. Half these high-grade cases show chromosomal rearrangements between the locus heterologous enhancer-bearing loci, while focal deletions adjacent non-coding gene PVT1 are enriched in -intact cases. To identify genomic drivers activation, we used high-throughput CRISPR-interference (CRISPRi) profiling candidate enhancers rearrangement partner loci...
Abstract We sought to identify mechanisms that activate MYC expression in germinal center B cell-(GCB) diffuse large B-cell lymphomas (DLBCL) the absence of rearrangement. High-throughput CRISPR-interference screens MYC-rearranged (n=4) and non-MYC-rearranged (n=2) GCB-DLBCL cell lines revealed a distal enhancer complex 436 kb downstream MYC, GME-1, was uniquely essential non-rearranged (MYC-intact) lines. studies confirmed growth inhibition downregulation upon GME-1 repression 4 DLBCL...
<div>Abstract<p>Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects the <i>ETV6</i> transcriptional repressor, including <i>ETV6–RUNX1</i><sup>+</sup> and <i>ETV6</i>-null B-ALL. show that repeat are direct activators previously identified...
<div>Abstract<p>Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects the <i>ETV6</i> transcriptional repressor, including <i>ETV6–RUNX1</i><sup>+</sup> and <i>ETV6</i>-null B-ALL. show that repeat are direct activators previously identified...
<p>Contains Supplementary Figures 1-12 and additional information about tables</p>
<p>Contains Supplementary Figures 1-12 and additional information about tables</p>
Introduction:The relationship between vitamin D receptor (VDR) polymorphisms and cardiovascular disease (CVD) is unclear.This study explores the correlation VDR genotypes, plasma concentrations of metabolites, CVD occurrence metabolic disorders.Method: Fifty-eight patients with were included.ApaI rs7975232 TaqI rs731236 genotyped using PCR-RFLP method.Circulating 25-hydroxyvitamin-D2, 25-hydroxyvitamin-D3, 3-epi-25-hydroxyvitamin D3 measured by a validated UPLC-MS/MS method.Results: ApaI...