A5066829684- Non-Invasive Vital Sign Monitoring
- ECG Monitoring and Analysis
- Diabetes Treatment and Management
- Cancer survivorship and care
- Atrial Fibrillation Management and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Medication Adherence and Compliance
- Diabetes Management and Research
- Sepsis Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Mobile Health and mHealth Applications
- Clinical practice guidelines implementation
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- CAR-T cell therapy research
- Diet and metabolism studies
- Neutropenia and Cancer Infections
- Electronic Health Records Systems
- Respiratory Support and Mechanisms
- Wireless Body Area Networks
- Lymphoma Diagnosis and Treatment
RWTH Aachen University
2020-2024
Universitätsklinikum Aachen
2020-2024
Heinrich Heine University Düsseldorf
2024
Düsseldorf University Hospital
2024
Integrated Oncology (United States)
2024
Witten/Herdecke University
2020-2023
The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. PTCL had clonal rearrangement, which was already detectable in the apheresis product CAR manufacturing and 7 months earlier autologous transplantation. Somatic
Wearables (= wearable computer) enable continuous and noninvasive monitoring of a range vital signs. Mobile cost-effective devices, combined with powerful data analysis tools, open new dimensions in assessing body functions ("digital biomarkers").To answer the question whether wearables are ready for use medical context, PubMed literature search their clinical-scientific using publications from years 2008 to 2018 was performed.A total 79 out 314 hits were on clinical trials wearables, which...
Abstract There is high mortality among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease (COVID-19). Important factors for COVID-19 are diabetes status and elevated fasting plasma glucose (FPG). However, the effect of glycaemic variability on survival has not been explored in ARDS. This single-centre cohort study compared several metrics goodness-of-fit requiring mechanical ventilation due to ARDS ICU at University Hospital...
Intensive treatment protocols for aggressive hematologic malignancies harbor a high risk of serious clinical complications, such as infections. Current techniques monitoring vital signs to detect complications are cumbersome and often fail diagnose them early. Continuous physical activity by means an upper arm medical wearable allowing 24/7 streaming parameters may be promising alternative.This single-arm, single-center observational trial evaluated symptom-related patient-reported outcomes...
Background: Digital health applications (DiGA) supporting the management of diabetes are among most commonly available digital technologies. However, transparent quality assurance DiGA and clinical proof a positive healthcare effect is often missing, which creates skepticism some stakeholders regarding usage reimbursement these applications. Methods: This article reviews recently established fast-track integration in German market, with emphasis on current impact for manufacturers,...
Type 2 diabetes, obesity-related metabolic syndrome, and insulin resistance are the most common disorders associated with increased cardiovascular risk. In addition, patients diabetes have an risk for a more severe course of influenza virus infection, pandemic. There is increasing evidence that vaccination in can safely effectively reduce all-cause mortality death. The effects appear to be effective when using higher-dose quadrivalent vaccines, although subgroup-specific separate analyses...
Serious clinical complications (SCC; CTCAE grade ≥ 3) occur frequently in patients treated for hematological malignancies. Early diagnosis and treatment of SCC are essential to improve outcomes. Here we report a deep learning model-derived SCC-Score detect predict from time-series data recorded continuously by medical wearable. In this single-arm, single-center, observational cohort study, vital signs physical activity were with wearable 31,234 h 79 (54 Inpatient Cohort (IC)/25 Outpatient...
Atrial fibrillation (AF) is the most common arrhythmia and has a major impact on morbidity mortality; however, detection of asymptomatic AF challenging. This study aims to evaluate sensitivity specificity non-invasive by medical wearable. In this observational trial, patients with admitted hospital carried wearable an ECG Holter (control) in parallel over period 24 h, while not physically restricted condition. The tight-fit upper armband employs photoplethysmography technology determine...
Hohe Serumkonzentrationen (>1800pg/ml) des Growth Differentiation Factor 15 (GDF-15) haben bei Patienten mit chronischer Herzinsuffizienz (HF) konsistent in verschiedenen Studien einen prognostischen Vorhersagewert für kardiovaskulären Tod und/oder Krankenhauseinweisungen aufgrund von HF gezeigt. und Diabetes mellitus oder reduzierter reduzierte Nierenfunktion weisen diesen erhöhten GDF-15-Spiegel auf.auf. Die Bedeutung Prädiabetes ist unklar, obwohl bereits dem Stadium Inzidenz...
Heart failure is an escalating burden on global healthcare systems. Modernizing heart care inevitable, with eHealth products poised to play important role. However, devices that can initiate and adjust medication are currently lacking. Consequently, this study aimed develop artificial intelligence-based decision engine provide guideline-based recommendations for disease-modifying in patients. We developed the by converting European Society of Cardiology (ESC) guidelines into Business Process...
Abstract Background Atrial fibrillation (A-fib) is the most common arrhythmia; however, detection of A-fib a challenge due to irregular occurrence. Purpose Evaluating feasibility and performance non-invasive medical wearable for A-fib. Methods In CoMMoD-A-fib trial admitted patients with high risk carried an ECG Holter (control) in parallel over period 24 hours under not physically restricted conditions. The tight-fit upper arm band employs photoplethysmography (PPG) technology enabling...
Abstract There is high mortality among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease 19 (COVID-19). Important factors for COVID-19 are diabetes status and elevated fasting plasma glucose (FPG). However, the effect of glycemic variability on survival has not been explored in ARDS. This single-centre cohort-study compared several metrics daily (DGV) goodness-of-fit requiring mechanical ventilation due to ARDS ICU at University...