A5083635759- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Biochemical Analysis and Sensing Techniques
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Risk and Safety Analysis
- Chromium effects and bioremediation
- Meta-analysis and systematic reviews
- Coffee research and impacts
- Obesity, Physical Activity, Diet
- Health, Environment, Cognitive Aging
- Environmental Toxicology and Ecotoxicology
- Pesticide Exposure and Toxicity
- Agricultural safety and regulations
- Dye analysis and toxicity
- Consumer Attitudes and Food Labeling
- Environmental Justice and Health Disparities
- Computational Drug Discovery Methods
- Per- and polyfluoroalkyl substances research
- Atmospheric and Environmental Gas Dynamics
- Pharmacogenetics and Drug Metabolism
- Heavy Metal Exposure and Toxicity
- Delphi Technique in Research
BioStrategies (United States)
2011-2025
ToxStrategies LLC (United States)
2025
Consumer Healthcare Products Association
2024
University of North Carolina at Asheville
2020
Shale gas exploration and production (E&P) has experienced substantial growth across the U.S. over last decade. The Barnett Shale, in north-central Texas, contains one of largest, most active onshore fields North America, stretching 5000 square miles having an estimated 15,870 producing wells as 2011. Given that these operations may occur relatively close proximity to populated/urban areas, concerns have been expressed about potential impacts on human health. In response concerns, Texas...
There are several standards that offer explicit guidance on good practice in systematic reviews (SRs) for the medical sciences; however, no similarly comprehensive set of recommendations has been published SRs focus human health risks posed by exposure to environmental challenges, chemical or otherwise. To develop an expert, cross-sector consensus view a key recommended practices planning and conduct sciences. A draft was derived from two existing biomedicine developed process, which engaged...
In 2016⁻2017, we conducted and published a systematic review on caffeine safety that set out to determine whether conclusions were presented in the heavily cited Health Canada assessment, remain supported by more recent data. To end, reviewed data from 380 studies between June 2001 2015, which identified an initial batch of over 5000 articles through stringent search evaluation process. current paper, use plain language summarize our process findings, with intent sharing additional context...
Traditional approaches for quantitatively characterizing uncertainty in risk assessment require adaptation to accommodate increased reliance on observational (vs. experimental) studies developing toxicity values. Herein, a case study with PFOA and PFOS vaccine response explores qualitative and-where possible-quantitative assessments of at each step the value development process when using data, including review appraisal individual studies, candidate selection, dose-response modeling,...
Abstract Tetrabromobisphenol A (TBBPA) is used in a diverse array of products to improve fire safety. The National Toxicology Program (NTP) recently completed 2‐year bioassay for TBBPA. objective the present study was develop cancer‐based and non‐cancer based toxicity value compare such appropriate estimates human exposure. Data from NTP 13‐week studies were selected candidate values. Benchmark dose modeling subsequent evaluation values resulted selection an oral reference (RfD) 0.6 mg kg −1...
Tetrabromobisphenol A (TBBPA), a nongenotoxic flame retardant, causes uterine tumors in female rats. proposed mode of action (MoA) for these involves an increase the bioavailability estradiol as result TBBPA inhibiting estrogen sulfotransferases (ES), enzymes responsible inactivating and enhancing elimination estradiol. The objective this study was to evaluate effect dose repeated administration on level TBBPA, TBBPA-glucuronide (GA) TBBPA-sulfate (S) conjugates plasma, liver uterus Wistar...
Sucralose is widely used as a sugar substitute. Many studies and authoritative reviews have concluded that sucralose non-carcinogenic, based primarily on animal cancer bioassays genotoxicity data. To add to the body of knowledge potential carcinogenicity sucralose, systematic assessment mechanistic data was conducted. This entailed using framework developed for quantitative integration related proposed key characteristics carcinogens (KCCs). Data from peer-reviewed literature ToxCast/Tox21...
Abstract Oral exposure to hexavalent chromium (Cr[VI]) induces intestinal tumors in mice. Mutagenic and nonmutagenic modes of action (MOAs) have been accepted by different regulatory bodies globally, the latter involving cytotoxicity-induced regenerative cell proliferation. However, concerns persist that all possible MOAs not fully considered. To address potential for alternative MOAs, mechanistic data represented existing two were evaluated. Relevant identified organized key characteristics...