A5031606152- Ubiquitin and proteasome pathways
- Endometrial and Cervical Cancer Treatments
- Pluripotent Stem Cells Research
- Endoplasmic Reticulum Stress and Disease
- Advanced MRI Techniques and Applications
- Autophagy in Disease and Therapy
- 3D Printing in Biomedical Research
- Breast Cancer Treatment Studies
- Synthesis of Tetrazole Derivatives
- Effects and risks of endocrine disrupting chemicals
- Genomics, phytochemicals, and oxidative stress
- Chemotherapy-induced cardiotoxicity and mitigation
- Carcinogens and Genotoxicity Assessment
- Nonmelanoma Skin Cancer Studies
- Advanced Neuroimaging Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Ultrasound and Hyperthermia Applications
- Urologic and reproductive health conditions
- Breast Lesions and Carcinomas
- Genital Health and Disease
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Heat shock proteins research
- Hypertrophic osteoarthropathy and related conditions
- Medical Imaging and Pathology Studies
University of Minnesota
2023-2025
University of Minnesota Medical Center
2023
Resonance Research (United States)
2023
The University of Texas MD Anderson Cancer Center
2011-2022
University of Arkansas – Fort Smith
2018-2021
National Center for Toxicological Research
2016-2018
United States Food and Drug Administration
2017
SSM Health Care
2016
BioStrategies (United States)
2015
Willis-Knighton Cancer Center
2013-2014
Twenty patients with known liver metastases were evaluated by unenhanced computed tomography (CT), scans enhanced ethiodized oil emulsion-13 (EOE-13), and magnetic resonance (MR) imaging three pulse sequences. Spin-echo (SE) 300/26 (repetition time/echo time, in msec) images prospectively demonstrated 95.4% of the detectable metastases; inversion recovery (IR) 1,500/100 time/inversion revealed 90.8%; EOE-13-enhanced CT showed 87.1%. SE 2,000/80 51.4%, 49.6%, metastases. The relationship...
The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box warnings hepatotoxicity (BBW-H) in product labeling. precise mechanisms and risk factors KI-induced are poorly understood. Here, the KIs were tested isolated rat liver mitochondria, an vitro system recently proposed to be a useful tool predict drug-induced humans. incubated mitochondria or submitochondrial particles at concentrations ranging from therapeutic maximal...
The first commercially available 7-T MRI scanner (Magnetom Terra) was approved by the FDA in 2017 for clinical imaging of brain and knee. After initial protocol development sequence optimization efforts volunteers, system, combination with an FDA-approved 1-channel transmit/32-channel receive array head coil, can now be routinely used examinations. ultrahigh field strength has advantages improved spatial resolution, increased SNR, CNR but also introduces new technical challenges. purpose...
DSC perfusion is an advanced imaging technique routinely used at 1.5T and 3T MRI. However, its utility not well known in 7T MRI systems. We aim to evaluate if a valid practicable tool A successful was performed 9 patients with FDA-approved system (Siemens Terra 1tx/32rx Nova head coil) 2023. Half-dose contrast administered by hand, followed saline flush. Acquisition initiated 45 seconds before injection. Voxel size 1.5 × 1.6 mm3. Perfusion maps were generated using either SyngoVia or...
The proteasome inhibitor bortezomib (Velcade) is a promising new agent for bladder cancer therapy, but inducible cytoprotective mechanisms may limit its potential efficacy. We used whole genome mRNA expression profiling to study the effects of on stress-induced gene in panel human cell lines. Bortezomib induced strong upregulation HSP70 isoforms HSPA1A and HSPA1B Hsp72 253J B-V SW780 (HSPA1A(high)) cells, only isoform UM-UC10 UM-UC13 (HSPA1A(low)) cells. stimulated binding heat shock...
Abstract Tetrabromobisphenol A (TBBPA) is used in a diverse array of products to improve fire safety. The National Toxicology Program (NTP) recently completed 2‐year bioassay for TBBPA. objective the present study was develop cancer‐based and non‐cancer based toxicity value compare such appropriate estimates human exposure. Data from NTP 13‐week studies were selected candidate values. Benchmark dose modeling subsequent evaluation values resulted selection an oral reference (RfD) 0.6 mg kg −1...
Lanthionine synthase C-like protein-1 (LanCL1) is a glutathione (GSH)-binding protein of uncertain function, widely expressed in mammalian cells. Recent data suggests that LanCL1 has S-transferase (GST)-like activity, while other reports claim suppresses mitogen-activated kinase (MAPK) phosphorylation. In the present study, recombinant human had less than 10% specific activity GST. When CRISPR-Cas9 was used to stably ablate from HeLa cells, resulting line sensitized H2O2 toxicity. [GSH],...
113 Background: The soluble form of the VEGFR2 receptor (sVEGFR2) neutralizes circulating VEGF, and functions as a negative feedback mechanism to enable partial inhibition VEGF-stimulated endothelial cell migration proliferation. In response tyrosine kinase activity, up-regulation VEGF expression down-regulation sVEGFR2 levels have been observed (Murukesh et al., 2010). Telatinib (tel) is novel orally available inhibitor that highly selective for VEGFR, PDGFR, KIT kinases at nanomolar...
Purpose: This study summarizes the results of an initial radiation survey Willis-Knighton Cancer Center in Shreveport, Louisiana. The facility houses IBA ProteusOne compact single room proton therapy unit coupled with a C230 cyclotron that operates at maximum energy 230 MeV. Methods: A calibrated meter was used for photon measurements to obtain reliable results. neutron detector as measuring instrument neutrons. locations and were planned carefully order get proper evaluation shielding...
Purpose: Toptimized dosimetry of a CT/MRI multi‐lumen brachytherapy applicator was planned to treat vaginal cancer after hysterectomy. Multichannel design cylinder includes several peripheral channels isotropically placed 5mm inside from surface with separate central channel allow single lumen as an option. The optimized plans were compared between single‐channel versus multi‐channel determine the sufficient coverage apex and other potential dosimetric advantages. Methods: CT simulation for...
Purpose: To compare the quality of 5‐channel vaginal cylinder treatment plans for endometrial cancer to single channel and 9‐channel plans. Using more channels tends spare rectum bladder, while creating hot spots longer planning times. The objective is determine if offer a beneficial compromise Methods: Fifteen from 3 patients were evaluated using Oncentra MasterPlan (Nucletron inc.) system. Each 15 was previously treated with 9 35mm diameter multi‐channel cylinder, Oncentra's IPSA inverse...
Purpose: To compare the dose distributions from HDR brachytherapy using interstitial catheter implants and Intracavitary Savi applicator for breast cancer patients following lumpectomy. Methods: We have treated over 200 post lumpectomy with (Cianna Medical) . The technique used a custom built template placement of catheters under image guidance. was placed into resected cavity expanded to cover CT criteria plan evaluation prescription covered 95 100% volume 1.5× prescribed <30% PTV 2.0 ×...
Abstract Epithelial to mesenchymal transition is a developmental pathway that has been shown have direct role in tumor progression and drug resistance. Increasing evidence suggests EMT (and MET) leads global changes chromatin architecture modifies expression of numerous genes. Interestingly, reports the literature indicate possible association between cyclooxygenase-2 (COX-2) EMT. COX-2 upregulated response inflammation, known be overexpressed multiple malignancies, including pancreatic...