A5017646807- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Viral gastroenteritis research and epidemiology
- Blood groups and transfusion
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Hepatitis C virus research
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Frailty in Older Adults
- Long-Term Effects of COVID-19
- Adolescent Sexual and Reproductive Health
- Cardiac Health and Mental Health
- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- Syphilis Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Reproductive tract infections research
- Influenza Virus Research Studies
- Pediatric health and respiratory diseases
- Molecular Biology Techniques and Applications
Lancet Laboratories
2020-2021
National Health Laboratory Service
2009-2010
Stellenbosch University
2009-2010
Accurate molecular methods to detect and quantify hepatitis B virus (HBV) DNA are essential diagnose chronic infections, guide treatment decisions, assess response treatment, determine risk of HBV-related complications. New generations real-time HBV assay platforms provide results in less than 2-3 h, with continuous loading specimens true random-access capability.We examined the clinical performance new Alinity m assay, run on fully automated, continuous, platform, accurately a large series...
Accurate, rapid detection of HIV-1 RNA is critical for early diagnosis, treatment decision making, and long-term management infection. We evaluated the diagnostic performance Alinity m assay, which uses a dual target/dual probe design against highly conserved target regions genome run on fully automated platform. This was an international, multisite study that compared assay to four commercially available assays routinely used in nine independent clinical laboratories. precision,...
Abstract Objectives Automated molecular analyzers have accelerated diagnosis, allowing earlier intervention and better patient follow-up. A recently developed completely automated analyzer, Alinity™ m (Abbott), offers consolidated, continuous, random-access testing that may improve laboratory workflow. Methods An international, multicenter study compared workflow metrics across various routine Alinity utilizing assays for human immunodeficiency virus type 1 (HIV-1), hepatitis C (HCV), B...
Nucleic acid testing is essential for the detection and quantification of HCV RNA in diagnosis infection treatment monitoring. The Alinity m assay was recently developed by Abbott Molecular rapid on fully automated, continuous, random-access analyzer.Our study assessed performance new a large series patient samples various genotypes. This international, multicentric evaluated linearity, precision, reproducibility its comparison to three other assays currently used clinical practice.The...
Regular HIV-1 viral load monitoring forms an essential part of any successful treatment programme. Abbott Molecular recently released the Alinity m assay to be run on System, a fully automated, continuous and random access analyser using ReadiFlex™ technology.Our study investigated performance in comparison cobas® test high-throughput molecular laboratory.We compared with test, performed both 4800 6800 systems at three clinically relevant thresholds (50, 200 1000 cp/mL).Excellent correlation...
Abstract In a resource‐constrained African setting, children suspected of being infected with HIV are often screened rapid antibody tests prior to definitive diagnosis viral genome detection. It has previously been shown that assay such as the Capillus™ HIV‐1/HIV‐2 test may have high false‐negative rate in infants. this study CD count and percentage, HIV‐1 load, antigen‐specific reactivity, age was explored predictors negative or low reactivity by assay. Young found be only factor associated...
Abstract Objectives Accurate and rapid diagnosis of sexually transmitted infections (STIs) is essential for timely administration appropriate treatment reducing the spread disease. We examined performance new Alinity m STI assay, a qualitative real-time multiplex PCR test simultaneous identification Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), Trichomonas vaginalis (TV) run on fully automated platform. Methods This international, multicenter study...
卒中后抑郁(poststroke depression, PSD)是一种常见病，可发生于卒中后的任何时间，影响约1/3的卒中存活者。PSD患者面临更高的恢复欠佳、复发性血管事件、生活质量差和死亡风险。尽管PSD非常普遍，但其诱发因素以及最佳预防和治疗策略仍不明确。本文是美国心脏协会(American Heart Association, AHA)针对PSD发布的首份科学声明。写作组成员由AHA卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命，负责与其专业领域相关的主题，进行适当的文献回顾，并参考已发表的临床和流行病学研究、临床和公共卫生指南、权威声明和专家意见。这份多学科声明提供了对PSD流行病学、病理生理学、转归、管理以及预防方面当前证据的全面回顾，指出了现有知识的不足，并提供了对临床实践的意义。