A5016072881- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Milk Quality and Mastitis in Dairy Cows
- Animal Genetics and Reproduction
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- Effects of Environmental Stressors on Livestock
- Meat and Animal Product Quality
- Probiotics and Fermented Foods
- melanin and skin pigmentation
- Protein Hydrolysis and Bioactive Peptides
- Animal Nutrition and Physiology
- Identification and Quantification in Food
- Genomic variations and chromosomal abnormalities
- Animal Behavior and Welfare Studies
- Microbial infections and disease research
- Animal Diversity and Health Studies
- Biochemical Analysis and Sensing Techniques
- Livestock Farming and Management
- Antimicrobial Peptides and Activities
- Ruminant Nutrition and Digestive Physiology
- Hair Growth and Disorders
- Agricultural Economics and Policy
- Animal Nutrition and Health
University of Palermo
2016-2025
Organizzazione per la Tutela Forestale, Ambientale e Agroalimentare
2008-2019
Abstract Heterozygosity-rich regions (HRR) are genomic of high heterozygosity, which may harbor loci related to key functional traits such as immune response, survival rate, fertility, and other fitness traits. This study considered 30 Italian 19 worldwide goat breeds genotyped with the Illumina GoatSNP50k BeadChip. The aim work was inter-breed relationships HRR patterns using Sliding Window (SW) Consecutive Runs (CR) detection methods. Genetic highlighted a clear separation between...
In the local breeds with small population size, one of most important problems is increase inbreeding coefficient (F). High levels lead to reduced genetic diversity and depression. The availability high-density single nucleotide polymorphism (SNP) arrays has facilitated quantification F by genomic markers in farm animals. Runs homozygosity (ROH) are contiguous lengths homozygous genotypes represent an estimate degree autozygosity at genome-wide level. current study aims quantify derived from...
In goats, classical genetic studies reported a large number of alleles at the <i>Agouti</i> locus with effects on coat color and pattern distribution. From these early studies, dominant <i>A</i><sup>Wt</sup> (white/tan) allele was suggested to cause white Saanen breed. Here, we sequenced coding region goat <i>ASIP</i> gene in 6 breeds (Girgentana, Maltese, Derivata di Siria, Murciano-Granadina, Camosciata delle Alpi, Saanen), different colors...
The goat (Capra hircus) represents one of the most important farm animal species. It is reared in all continents with an estimated world population about 800 million animals. Despite its importance, studies on genome are still their infancy compared to those other Comparative mapping between cattle and showed only a few rearrangements agreement similarity chromosome banding. We carried out cross species cattle-goat array comparative hybridization (aCGH) experiment order identify copy number...
Because very large numbers of single nucleotide polymorphisms (SNPs) are now available throughout the genome, they particularly suitable for detection genomic regions where a reduction in heterozygosity has occurred and offer new opportunities to improve accuracy inbreeding ([Formula: see text]) estimates. Runs homozygosity (ROH) contiguous lengths homozygous segments genome two haplotypes inherited from parents identical. Here, we investigated occurrence distribution ROH using medium-dense...
Summary The availability of dense single nucleotide polymorphism ( SNP ) assays allows for the determination autozygous segments based on runs consecutive homozygous genotypes ROH ). aim present study was to investigate occurrence and distribution in 21 Italian sheep breeds using medium‐density order characterize autozygosity identify genomic regions that frequently appeared within individuals, namely islands. After filtering, final number animals s retained analyses were 502 46 277...
Agouti and Extension loci control the relative amount of eumelanin pheomelanin production in melanocytes that, turn, affects pigmentation skin hair. The locus encodes melanocortin 1 receptor (MC1R) whose permanent activation, caused by functional mutations, results black coat colour, whereas other inactivating mutations cause red colour different mammals.The whole coding region MC1R gene was sequenced goats six breeds showing colours (Girgentana, white cream with usually small spots face;...
The current extensive use of the domestic goat (Capra hircus) is result its medium size and high adaptability as multiple breeds. extent to which genetic variability was influenced by early domestication practices largely unknown. A common standard analyze maternally-inherited livestock species through complete sequencing entire mitogenome (mitochondrial DNA, mtDNA). We present first survey mitogenomic based on 84 sequences selected from an initial collection 758 samples that represent 60...
In the last 50 years, diversity of cattle breeds has experienced a severe contraction. However, in spite growing diffusion cosmopolite specialized breeds, several local are still farmed Italy. Genetic characterization represents an essential step to guide decisions management farm animal genetic resources. The aim this work was provide high-resolution representation genome-wide and population structure Italian using medium-density single nucleotide polymorphism (SNP) array.After quality...
Runs of homozygosity (ROH) are widely used as predictors whole-genome inbreeding levels in cattle. They identify regions that have an unfavorable effect on a phenotype when homozygous, but also the genes associated with traits economic interest present these regions. Here, distribution ROH islands and enriched within four dairy cattle breeds were investigated. Cinisara (71), Modicana (72), Reggiana (168) Italian Holstein (96) individuals genotyped using 50K v2 Illumina BeadChip. The genomic...
Domestic species such as cattle (Bos taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed structuring diversity 21 autochtonous breeds from whole Mediterranean basin performed genome-wide association analyses with covariables discriminating different subtypes. This provided insights...
Massese is an Italian dairy sheep breed characterized by animals with black skin and horns or apparent grey hairs. Owing to the presence of these two coat colour types, this can be considered interesting model evaluate effects gene polymorphisms on phenotypic trait. Two main loci have been already shown affect in sheep: Agouti Extension coding for agouti signalling protein (ASIP) melanocortin 1 receptor (MC1R) genes, respectively. The locus affected a large duplication including ASIP that...
Three Lactococcus lactis subsp. cremoris strains were used to develop ad hoc biofilms on the surfaces of virgin wooden vats for cheese production. Two (TZ) tested under controlled conditions (pilot plant), and two (TA) uncontrolled (industrial plant). In each plant, one vat (TA1 TZ1) was control, traditional production PDO Vastedda della Valle del Belìce (Vastedda) cheese, (TA2 TZ2) experimental performed after lactococcal biofilm activation daily addition a natural whey starter culture...
Analysis of genomic data is becoming increasingly common in the livestock industry and findings have been an invaluable resource for effective management breeding programs small endangered populations. In this paper, with goal highlighting potential analysis populations, genome-wide levels linkage disequilibrium, measured as squared correlation coefficient allele frequencies at a pair loci, population size, runs homozygosity (ROH) genetic diversity parameters, were estimated Barbaresca sheep...
Abstract Background Assessment of genetic diversity and population structure provides important control metrics to avoid erosion, inbreeding depression crossbreeding between exotic locally-adapted cattle breeds since these events can have deleterious consequences eventually lead extinction. Historically, the Alpine Arc represents an pocket biodiversity with a large number autochthonous that provide fundamental source income for entire regional economy. By using genotype data from...
Genomic regions subjected to selection frequently show signatures such as within-population reduced nucleotide diversity and outlier values of differentiation among differentially selected populations. In this study, we analyzed 50K SNP genotype data 373 animals belonging 23 sheep breeds different geographic origins using the Rsb (extended haplotype homozygosity) FST statistical approaches, identify loci associated with fat-tail phenotype. We also checked if these putative overlapped...
Copy number variation (CNV) is a major source of genomic structural variation. The aim this study was to detect CNV regions (CNVR) in Valle del Belice dairy sheep population and identify those affecting milk production traits. GO analysis identified possible candidate genes pathways related the selected We CNVs 416 individuals genotyped using Illumina OvineSNP50 BeadChip array. association correlation-trend test model examined with Golden Helix SVS 8.7.0 tool. Significant were detected when...
The objective of this study was to uncover genomic regions explaining a substantial proportion the genetic variance in milk production traits and somatic cell score Valle del Belice dairy sheep. Weighted single-step genome-wide association studies (WssGWAS) were conducted for yield (MY), fat (FY), percentage (FAT%), protein (PY), (PROT%), (SCS). In addition, our aim also identify candidate genes within that explained highest proportions variance. Overall, full pedigree consists 5534 animals,...
The mitochondrial hypervariable region 1 (HVR1) sequence of 67 goats belonging to the Girgentana, Maltese and Derivata di Siria breeds was partially sequenced in order present first phylogenetic characterization Sicilian goat breeds. These sequences were compared with published Indian Pakistani domestic wild goats. Mitochondrial lineage A observed most However, three Girgentana haplotypes highly divergent from Capra hircus clade, indicating that a new mtDNA found.
Fat tail in sheep represents a valuable energy reserve for facing future climate changes. The identification of genes with role the fat-tail phenotype may contribute to understanding physiology fat deposition and mechanisms adaptation. Genotypic data obtained OvineSNP50K array 13 thin-tail breeds from Italy were used identify selection signatures through pairwise thin- versus breed comparisons, following Mediterranean area: two unique Italian (Barbaresca Laticauda), Barbary Libya, Ossimi...