A5073053190- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Milk Quality and Mastitis in Dairy Cows
- Animal Genetics and Reproduction
- Effects of Environmental Stressors on Livestock
- Prion Diseases and Protein Misfolding
- Wheat and Barley Genetics and Pathology
- Helminth infection and control
- Genetic diversity and population structure
- Animal Nutrition and Physiology
- Genetics and Plant Breeding
- Cancer-related molecular mechanisms research
- Livestock Management and Performance Improvement
- Mycobacterium research and diagnosis
- Animal Behavior and Welfare Studies
- Agricultural Systems and Practices
- Animal Disease Management and Epidemiology
- Reproductive Physiology in Livestock
- Trace Elements in Health
- Meat and Animal Product Quality
- Identification and Quantification in Food
- Ruminant Nutrition and Digestive Physiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Respiratory Support and Mechanisms
- Parasitic Infections and Diagnostics
Sardegna Agricoltura
2012-2024
Ospedale di Mirano
2023-2024
University of Sassari
2020
Istituto Zooprofilattico Sperimentale della Sardegna
1997-2007
University of Parma
2005
Among the European countries, Italy counts largest number of local goat breeds. Thanks to recent availability a medium-density SNP (single nucleotide polymorphism) chip for goat, genetic diversity Italian populations was characterized by genotyping samples from 14 breeds that originate different geographical areas with more than 50 000 SNPs evenly distributed on genome. Analysis data revealed high levels polymorphism and an underlying North–south geographic pattern highlighted both first...
Italy counts several sheep breeds, arisen over centuries as a consequence of ancient and recent genetic demographic events. To finely reconstruct structure relationships between Italian sheep, 496 subjects from 19 breeds were typed at 50K single nucleotide polymorphism loci. A subset foreign the Sheep HapMap dataset was also included in analyses. Genetic distances (as visualized either network or multidimensional scaling analysis identical by state distances) closely reflected geographic...
In the last 50 years, diversity of cattle breeds has experienced a severe contraction. However, in spite growing diffusion cosmopolite specialized breeds, several local are still farmed Italy. Genetic characterization represents an essential step to guide decisions management farm animal genetic resources. The aim this work was provide high-resolution representation genome-wide and population structure Italian using medium-density single nucleotide polymorphism (SNP) array.After quality...
ABSTRACT Prions are misfolded proteins that infectious and naturally transmitted, causing a fatal neurological disease in humans animals. Prion shedding routes have been shown to be modified by inflammation excretory organs, such as the kidney. Here, we show sheep with scrapie lentiviral mastitis secrete prions into milk infect nearly 90% of naïve suckling lambs. Thus, lentiviruses may enhance prion transmission, conceivably sustaining infections flocks for generations. This study also...
Abstract Local adaptation of animals to the environment can abruptly become a burden when faced with rapid climatic changes such as those foreseen for Italian peninsula over next 70 years. Our study investigates genetic structure goat populations and links it how genetics might evolve 50 We used one largest national datasets including > 1000 goats from 33 across collected by Goat Consortium genotyped k markers. results showed that be discriminated in three groups reflective geography its...
Summary The objective of this work was to characterize the complete coding region ovine acyl CoA:diacylglycerol acyltransferase 1 ( DGAT1 ) gene three Italian sheep breeds: Sarda, Altamurana and Gentile di Puglia. Characterization accomplished by direct sequencing 8676 bp relevant DNA, including introns partial 5′ 3′ untranslated regions (UTRs). We detected five novel SNPs; one SNP (g.5553C>T) is located in intron 2, has similar frequencies breeds showed a negative association with milk...
Gastroinestinal nematodes (GIN) are one of the major health problem in grazing sheep. Although genetic variability resistance to GIN has been documented, traditional selection is hampered by difficulty recording phenotypes, usually fecal egg count (FEC). To identify causative mutations or markers linkage disequilibrium (LD) be used for selection, detection quantitative trait loci (QTL) FEC based on disequilibrium-linkage analysis (LDLA) was performed 4097 ewes (from 181 sires) all genotyped...
The inbreeding coefficient is an important parameter for livestock management. Small ruminant breeders and associations mainly rely on pedigree information, but genomic tools are gaining relevance, overcoming possible inconsistencies. This study investigates the relationship between pedigree-based in two goat four sheep dairy breeds. Pedigree data (medium-density SNPchip) were obtained 3107 goats 2511 sheep. We estimated depth (number of fully traced generations, FullGen) (FPED), as well...
A common dataset was simulated and made available to participants of the XVIth QTL-MAS workshop. Tasks for were detect QTLs affecting three traits, assess their possible pleiotropic effects, evaluate breeding values in a candidate population without phenotypes using genomic information. Four generations consisting 20 males 1000 females generated by mating each male with 50 females. The genome consisted 5 chromosomes, 100 Mb size carrying 2,000 equally distributed SNPs. Three traits order...
Cystic echinococcosis (CE), a zoonotic disease caused by the larval stage of tapeworm Echinococcus granulosus sensu lato (s.l.), is worldwide public health problem. stricto (s.s.), associated with G1 and G3 genotypes, endemic high prevalence in Mediterranean basin. The parasite’s life cycle comprises definitive hosts (canids) intermediate (ruminants) can occasionally involve humans. main aim this research was to confirm diagnosis 13 patients suspected CE who presented different complications...
ABSTRACT Thirty-seven goats carrying different prion protein genotypes ( PRNP ) were orally infected with a classical scrapie brain homogenate from wild-type (ARQ/ARQ) sheep and then mated to obtain 2 additional generations of offspring, which kept in the same environment allowed be naturally exposed scrapie. Occurrence clinical or subclinical was observed experimentally (F 0 only one 1b offspring groups. In both groups F ), R154H, H154H, R211Q, P168Q-P240P dimorphisms died after longer...
The detection of regions that affect quantitative traits (QTL), to implement selection assisted by molecular information, remains particular interest in dairy sheep for which genetic gain is constrained the high costs large-scale phenotype and pedigree recording. QTL based on combination linkage disequilibrium analysis (LDLA) most suitable approach family-structured populations. main issue performing LDLA mapping handling identity-by-descent (IBD) probability matrix. Here, we propose use...