A5087903489- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Research on Leishmaniasis Studies
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Synthesis and Biological Evaluation
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Vitamin K Research Studies
- Complement system in diseases
- Pneumonia and Respiratory Infections
- Health Sciences Research and Education
- Emergency and Acute Care Studies
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Adipose Tissue and Metabolism
- SARS-CoV-2 detection and testing
- Hormonal Regulation and Hypertension
- Heparin-Induced Thrombocytopenia and Thrombosis
- Liver Disease and Transplantation
- Zoonotic diseases and public health
- Virology and Viral Diseases
- Leptospirosis research and findings
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Euclid Network
2023
National University of the Littoral
2014-2022
// Estefanía Prochetto 1 , Carolina Roldán Iván A. Bontempi 1,2 Daiana Bertona Luz Peverengo Miguel H. Vicco 2 M. Rodeles Ana R. Pérez 3 S. Marcipar and Gabriel Cabrera Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina Médicas, IDICER-CONICET Instituto Inmunología, Rosario, Correspondence to: Cabrera, email: Keywords : Trypanosoma cruzi, trans-sialidase, vaccine, foxp3 regulatory T cells, myeloid-derived suppressor Immunology Microbiology...
Abstract The use of chimeric molecules fusing several antigenic determinants is a promising strategy for the development low-cost, standardized and reliable kits to determine specific antibodies. In this study, we designed assessed novel recombinant chimera that complements performance our previously developed chimera, CP1 [FRA SAPA antigens (Ags)], diagnose chronic Chagas disease. new protein, named CP3, composed MAP, TcD TSSAII/V/VI determinants. We compared both Ags using panel 67...
Aim: The development of vaccines against Trypanosoma cruzi remains in an exploratory stage. Despite several antigen candidates have been evaluated, a comparison among the performance immunogens cannot be carried out because available reports differ formulations and infection model. In this work, we compared protective capacity seven T. antigens same model five new two well-established candidates. Materials & methods: We evaluated highly immunogenic proteins that contain tandem repeats (FRA...
Introduction: ascites is one of the most common complications cirrhosis associated with a high rate mortality. Although several scores have been developed in order to assess prognosis disease, they were designed for predicting liver transplantation requirements and mortality short term, but not while hospital. The aim this study was weigh risk factors in-hospital adult patients due alcoholic cirrhosis. Material methods: we performed cross-sectional 180 diagnosis portal hypertension alcohol...
Background. Chagas disease is a parasite infection caused by the protozoan Trypanosoma cruzi. Its most common complications chronic heart but impairments of systemic vasculature also has been observed. Although different mechanisms that regulate blood pressure are disrupted, to our knowledge data on association hypertension and scarce. In this regard we evaluate whether constitutes high risk factor. Materials methods. We recruited 200 individuals, half them with positive serology for T. They...
To evaluate the seroprevalence of COVID-19 infection in pauci-symptomatic and asymptomatic people, associated epidemiological factors, IgG antibody kinetic over a 5-month period to get better knowledge disease transmissibility rate susceptible persons that might be infected.Seroprevalence was evaluated by cross-sectional study based on general population Santa Fe, Argentina (non-probabilistic sample) carried out between July November 2020. A subgroup 20 seropositive individuals followed-up...
several scores were developed in order to improve the determination of community acquired pneumonia (CAP) severity and its management, mainly CURB-65 SACP score. However, none them evaluated for risk assessment in-hospital mortality, particularly individuals who non-immunosuppressed and/or without any comorbidity. In this regard, present study was carried out.we performed a cross-sectional 272 immunocompetent patients comorbidities with diagnosis CAP. Performance CURB- 65 SCAP predicting...
Autoantibodies cross-reacting with the β1 adrenergic receptor (anti-β1AR and anti-p2β) cardiac myosin antigens (anti-B13) have been related to pathogenesis of chronic Chagas heart disease (CCHD). Studies exploring their levels in different stages are scarce. We aimed evaluate relationship these autoantibodies clinical profile patients, especially regarding classificatory accuracy severe presentation failure.We conducted a cross-sectional study 155 T. cruzi-seropositive patients 26 age-...
Introducción: En las personas que viven con el virus de la inmunodeficiencia humana (PVVIH) se han descripto desregulaciones metabólicas podrían vincularse a un mayor riesgo cardiovascular.
 Objetivo: Evaluar espesor del tejido adiposo epicárdico (ETAE) y relación mismo parámetros clínicos bioquímicos cardiovascular en adultos VIH, comparados controles seronegativos.
 Materiales métodos: Observacional, inclusión prospectiva. Se incluyeron PVVIH >18 años seronegativos para los...
chronic Chagas heart disease (CCHD) is the most common manifestation of American Trypanosomiasis, causing about 50,000 deaths annually. Several factors bear correlation with severity CCHD. However, to our knowledge, assessment on contribution major cardiovascular risk (CRF), such as hypertension and atherogenic dyslipidemia (AD) CCHD scarce, despite their well-established role in coronary artery disease, failure stroke.to explore potential relationship blood pressure AD clinical profile...
Since the immune response mounted by host to a particular microorganism might be influenced acquired immunological experience due previous contact with other microorganisms, we performed cross-sectional study explore pattern of Trypanosoma cruzi infection-related antibodies in T. cruzi-seropositive individuals presenting concomitant tuberculosis, or antecedent BCG vaccination. Sampled were grouped as follows: patients Chagas disease, not vaccinated BCG, who further developed pulmonary...
Potential activation of β2 adrenergic receptors (β2AR) by specific autoreactive antibodies (Abs) that arise during the host reaction to Trypanosoma cruzi, could contribute elevated prevalence metabolic disturbances described in patients with chronic Chagas disease (CCD). This study aimed determine anti-β2AR Abs CCD, as well correlation these presence glucose and lipid metabolism disturbances, order explore their association an insulin resistance profile. Additionally, we tested functional...