A5065079507- Spinal Cord Injury Research
- Veterinary Pharmacology and Anesthesia
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Nicotinic Acetylcholine Receptors Study
- Reproductive System and Pregnancy
- Veterinary Medicine and Surgery
- Hypothalamic control of reproductive hormones
- Anesthesia and Sedative Agents
- Reproductive Physiology in Livestock
- Pregnancy and preeclampsia studies
- Veterinary Oncology Research
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Oral and Maxillofacial Pathology
- Hernia repair and management
- Oral microbiology and periodontitis research
- Pediatric Pain Management Techniques
- Periodontal Regeneration and Treatments
- Comparative Animal Anatomy Studies
- Spinal Dysraphism and Malformations
- Marine Toxins and Detection Methods
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Oral and gingival health research
Universidade Estadual de Santa Cruz
2015-2025
ORCID
2022
Amazon (United States)
2021
Universidade Federal de Minas Gerais
2012-2017
Fundação de Apoio a Pesquisa do Estado de Goiás
2016
Universidade Federal do Paraná
2014
Universidade Federal de Viçosa
2002-2006
This study aimed to evaluate the therapeutic potential of amantadine in a vincristine-induced peripheral neuropathy model rats. Forty-eight male Wistar rats were used. The treated groups received oral at doses 2, 5, 12, 25 and 50 mg/kg, with daily applications for 14 days. mechanical paw withdrawal threshold was measured using digital analgesimeter. Immunohistochemical analysis IL-6, TNFα, MIP1α, IL-10, CX3CR1, CXCR4, SOD, CAT GPx, enzymatic activity CAT, SOD GPx performed, addition...
Oxidative stress (OS) and endoplasmic reticulum (ERS) are at the genesis of placental disorders observed in preeclampsia, intrauterine growth restriction, maternal hypothyroidism. In this regard, cationic manganese porphyrins (MnPs) comprise potent redox-active therapeutics high antioxidant anti-inflammatory potential, which have not been evaluated metabolic gestational diseases yet. This study therapeutic potential two MnPs, [MnTE-2-PyP]5+ (MnP I) [MnT(5-Br-3-E-Py)P]5+ II), fetal-placental...
Maropitant is a neurokinin-1 (NK1) receptor antagonist that can be used for pain management. The objective of this study was to evaluate the effect continuous infusion two doses maropitant on cardiorespiratory parameters and its postoperative analgesic in cats undergoing ovariohysterectomy. Thirty were randomly assigned one three groups (10 each group): control group (CG) received 10 ml/kg/h Ringer’s lactate; GM30 GM100 first an intravenous (IV) bolus 1 mg/kg maropitant; then 30 μ g/kg/h 100...
This study aimed to evaluate the immunomodulatory and neuroprotective effects of allogeneic cryopreserved mesenchymal stem cells (MSCs) on spinal cord injury.A total 120 rats were distributed into following groups: negative control (NC) -without injury, positive (PC) -with injury without treatment, group Genetics Molecular Research 16 (1): gmr16019555 treated with MSC (GMSC) treated.Motor function was evaluated by BBB test at 24, 48, 72 h 8 21 postoperative days.Spinal cords histopathology...
Maternal hypothyroidism is associated with fetal growth restriction, placental dysfunction, and reduced kisspeptin/Kiss1R at the maternal-fetal interface. Kisspeptin affects trophoblastic migration has antioxidant immunomodulatory activities. This study aimed to evaluate therapeutic potential of kisspeptin in fetal-placental dysfunction hypothyroid Wistar rats. Hypothyroidism was induced by daily administration propylthiouracil. Kisspeptin-10 (Kp-10) treatment performed every other day or...
This study aimed to evaluate the effect of preemptive administration amantadine on postoperative analgesia in cats undergoing ovariohysterectomy and its influence physiological parameters. Twenty healthy domestic scheduled undergo at Santa Cruz State University, Ilhéus, were divided into two groups: control group (Group C; n = 10) A; 10). The Group C received placebo capsules 30 min prior standard anesthetic protocol, whereas those A 5 mg/kg orally protocol. Postoperative pain was assessed...
Objective To determine the effective dose and therapeutic potential of maropitant using through expression mediators oxidative stress, inflammatory unfolded protein response (UPR) (bio) markers on spinal cord a model neuropathic pain induced chronic constriction injury (CCI) in rats. Study design Randomized, blinded, prospective experimental study. Animals 98 male Wistar Methods Rats were anesthetized with sevoflurane after CCI, they randomly assigned to following groups that received:...
Abstract Background Multimodal analgesia consists of the combination analgesic drugs at low doses to act in different places along path pain. Studies with continuous infusion cats are not common. This study aimed evaluate effect maropitant, lidocaine and ketamine alone or (intravenous bolus + subsequent intravenous infusion) management acute postoperative pain undergoing ovariohysterectomy. Seventy healthy an ovariohysterectomy received a standard anesthetic protocol consisting acepromazine...
Hypothyroidism compromises the testicular redox status and is associated with reduced sperm quality infertility in men. In this regard, studies have demonstrated antioxidant potential of kisspeptin reproductive metabolic diseases. study, we evaluate effects kisspeptin-10 (Kp10) on redox, as well mediators unfolded protein response (UPR) adult rats hypothyroidism. Adult male Wistar were randomly separated into Control (n = 15), Hypo 13) + Kp10 14) groups, hypothyroidism was induced...
A 13-month-old female domestic shorthair cat presented with a 10-month history of polyuria and polydipsia that began after having been hit by car. Neurological examination revealed visual deficits an absent bilateral menace response. Hematological serum biochemical analyses were within reference values, but hyposthenuria was identified. Failure to concentrate urine during the water deprivation test followed increase in specific gravity administration synthetic antidiuretic hormone (ADH)...
This study evaluates whether intrathecal MVIIA injection after spinal cord injury (SCI) elicits neuroprotective effects. The test rats were randomly distributed into six groups- sham, placebo, 2.5 μM, 5 10 and 20 μM-and administered the treatment four hours SCI. After optimal dose (MVIIA μM) was defined, best time for application, one or hours, analyzed. Locomotor hind limb function side effects assessed. Forty-eight immediately euthanasia, segments removed from rats. Cell viability,...
Abstract Failures in hypothalamic kisspeptin/Kiss1r signaling are associated with infertility, and vitro studies have shown that kisspeptin can modulate angiogenesis immune activity. Because there is no vivo research on the functional relationship between these factors reproductive system, especially domestic cats, we evaluated expression profile of angiogenic immunological mediators genital tract cyclic cats those pyometra. The uterus diestrus exhibited greater gene protein Kiss1, as well...
The Kisspeptin/Kiss1r system is a key regulator of reproduction by stimulating gonadotrophin-releasing hormone and luteinizing release, in vitro studies have shown that Kisspeptin can modulate angiogenesis immune function, factors are also essential for However, there no on the expression at maternal-fetal interface domestic cats its relationship with angiogenic immunological mediators. Thus, our objective was to evaluate spatiotemporal profile mediators uterus placenta during pregnancy....
Objectives The aim of this study was to evaluate the expression profile sex steroid receptors and redox mediators in uterus domestic cats with pyometra. Methods Twelve were used divided into groups: (1) non-gestational healthy diestrus (n = 7) (2) pyometra 5). plasma profiles estradiol progesterone (P 4 ) as well uterine levels alpha (ERα), (PR) androgen (AR) receptors, antioxidant enzymes superoxide dismutase 1 (SOD1), catalase glutathione peroxidase (GPX1), oxidative damage marker...
Background: Canine Transmissible Venereal Tumor (cTVT) is a neoplasia that affects mainly the genital organs of dogs, but can rich extragenital sites as well. It´s tumor characterized microscopically by presence vacuolized round cells. Transmission occurs implantation these cells in non-affected tissues and treatment based on vincristine chemotherapy.Cases: Case 1. A 5-year-old intact male Poodle, presenting an increase volume nasal plane came for veterinary care at private clinic. The...
Maropitant, an antagonist of neurokinin-1 (NK-1) receptors, blocks the pharmacological action substance P on central and peripheral nervous systems. The objective this study was to compare antinociceptive cardiorespiratory effects continuous intraoperative infusion maropitant with ketamine lidocaine in female dogs undergoing unilateral radical mastectomy. Twenty-four were used divided randomly into two groups (n = 12). GLK group received bolus (1.0 mg/kg), (1.5 (10 mcg/kg/min 50 mcg/kg/min),...