A5010016062- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Erythrocyte Function and Pathophysiology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Invertebrate Immune Response Mechanisms
- Ion channel regulation and function
- Antimicrobial Peptides and Activities
- Marine Invertebrate Physiology and Ecology
- Global Energy Security and Policy
- Immune Response and Inflammation
- Diet and metabolism studies
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Lipid Membrane Structure and Behavior
- Peptidase Inhibition and Analysis
- Blood groups and transfusion
- Rabies epidemiology and control
- Viral-associated cancers and disorders
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Silk-based biomaterials and applications
- Insect and Pesticide Research
- Food composition and properties
Université de Rennes
2024
L. A. Orbeli Institute of Physiology NAS RA
2016-2022
National Academy of Sciences of Armenia
2021-2022
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2021-2022
Inserm
2020-2021
Centre National de la Recherche Scientifique
2021
Foie, Métabolisme, Cancer
2020
Université Rennes 2
2019
Abstract The global pandemic of metabolic diseases has increased the incidence hepatocellular carcinoma (HCC) in context non‐alcoholic steatohepatitis (NASH). downregulation E3 ubiquitin ligase TRIM21 been linked to poor prognosis different cancers including HCC. In order investigate role liver cancer progression on NASH, Trim21 +/+ and −/− male mice were injected with streptozotocin at neonatal stage. hypoinsulinemic then fed a high‐fat high‐cholesterol diet (HFHCD) for 4, 8 or 12 weeks....
Small regulatory RNAs (sRNAs) are key players in bacterial networks. Monitoring their expression inside living colonized or infected organisms is essential for identifying sRNA functions, but few studies have looked at during host infection with pathogens. Insufficient vivo monitoring attest to the difficulties collecting such data, we therefore developed a non-mammalian model using larval Galleria mellonella analyze roles of Staphylococcus aureus sRNAs and quickly determine possible...
Abstract Introduction The aim of the present study was to describe autonomic urethral sphincter (US) innervation using specific muscular and neuronal antibody markers 3D reconstruction. Material methods We performed en‐bloc removal entire pelvis three male human fetuses between 18 40 weeks. Serial whole mount sections (5 μm intervals) were stained investigated. with Masson's trichrome Eosin Hematoxylin, immunostained with: anti‐SMA for smooth muscle; anti‐S100 all nerves; anti‐PMP22...
Angiotensin-converting enzyme 2 (ACE2) is the receptor of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) causing disease 2019 (COVID-19). Transmembrane serine protease (TMPRSS2) a coreceptor. Abnormal hepatic function in COVID-19 suggests specific or bystander liver disease. Because cancer cells express ACE2 viral receptor, they are widely used as models SARS-CoV-2 infection vitro. Therefore, purpose this study was to analyze and TMPRSS2 expression localization human cancers...
Abstract The sustained immunosuppression associated with severe sepsis favors an increased susceptibility to secondary infections and remains incompletely understood. Plasmablast plasma cell subsets, whose primary function is secrete antibodies, have emerged as important suppressive populations that expand during sepsis. In particular, supports CD39 hi plasmablast metabolic reprogramming adenosine‐mediated activity. Arginine deficiency has been linked risk of in Overcoming arginine shortage...
Viper venom as a hemolytic biochemical “cocktail” of toxins, primarily cause to the systemic alteration blood cells. In sixties and seventies, human erythrocytes were extensively studied, but mechanical chemical stresses commonly exerted on red cells continue attract interest scientists for study membrane structure function. Here we monitor effect Vipera latifi ghost membranes using phase contrast microscopy changes in ATPase activity under snake influence vitro. The ion pumps (Na+,...
Արյան խմբերի հակածինները պոլիմորֆ հատկանիշներ են, որոնք ժառանգում են անհատները կամ պոպուլյացիաները: խմբերը հաճախակի թիրախ համաճարակաբանական հետազոտություններում, քանի որ գենետիկորեն որոշված են` հայտնի էքսպրեսիայով: Դրանք տոքսինների, մակաբույծների և մանրէների ընկալիչներ կարող նպաստել գաղութացմանը ներխուժմանը, նաև խոչընդոտել օրգանիզմի ինքնամաքրումը: ABO-հակամարմինները կարելի է համարել բնածին իմունային համակարգի մաս որոշ բակտերիալ պաթոգենների, տոքսինների ABO-հակածիններ կրող վիրուսների դեմ...
The purpose of this work is to reveal the transnational multi-layered political role diaspora, particularly main actor its activity - institution ethnic lobbying, which implies dual relations between homeland and host state. article aims understand place lobbying as a factor in modern international relations. Historical-comparative, structural-operational behavioral methods scientific analysis were used achieve goal research solution set problems. It was concluded that, lobby groups aimed...