A5006716940- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Breast Cancer Treatment Studies
- Organ and Tissue Transplantation Research
- Breast Lesions and Carcinomas
- Maternal and fetal healthcare
- Gynecological conditions and treatments
- Immune cells in cancer
- Colorectal and Anal Carcinomas
- Ectopic Pregnancy Diagnosis and Management
- Cancer Risks and Factors
- Cancer and Skin Lesions
- Pelvic floor disorders treatments
- Reproductive Health and Contraception
- Immune Response and Inflammation
- Appendicitis Diagnosis and Management
- Reconstructive Surgery and Microvascular Techniques
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
Institut de Recherche en Santé, Environnement et Travail
2018-2025
Inserm
2016-2025
Centre Hospitalier Universitaire de Rennes
2016-2025
Université de Rennes
2016-2025
École des Hautes Études en Santé Publique
2018-2025
Oncogenesis Stress Signaling
2015-2024
Centre Eugène Marquis
2012-2024
Hôpital Pasteur
2016-2024
Centre Hospitalier Universitaire de Nice
2016-2024
Service de la Santé Publique
2024
Masculinization depends on the fetal testis. Exposure of human fetus during pregnancy to paracetamol and/or other mild analgesics is associated with an increased risk cryptorchidism. We aimed determine whether disrupted morphology and endocrine function used in vitro system based culture testes exposed or not paracetamol, its metabolite N-(4-hydroxyphenyl)-arachidonoylethanolamide (AM404), aspirin, indomethacin, ketoconazole at 10−4 10−7 M. The study was conducted University Rennes I. Human...
In the context of COVID-19 pandemic, specific recommendations are required for management patients with gynecologic cancer.The FRANCOGYN group National College French Gynecologists and Obstetricians (CNGOF) convened to develop based on consensus conference model.If a patient cancer presents COVID-19, surgical should be postponed at least 15 days. For cervical cancer, radiotherapy concomitant radiochemotherapy could replace surgery as first-line treatment value lymph node staging reviewed...
BackgroundThe discovery of a saliva-based micro–ribonucleic acid (miRNA) signature for endometriosis in 2022 opened up new perspectives early and noninvasive diagnosis the disease. The 109-miRNA saliva is product miRNA biomarkers artificial intelligence (AI) modeling. We designed multicenter study to provide external validation its diagnostic accuracy. present here an interim analysis.MethodsThe first 200 patients included prospective ENDOmiRNA Saliva Test (NCT05244668) were analysis....
Abstract Introduction Uterine transplantation is currently intended for women with absolute uterine infertility. Since proof of the concept in 2014, many countries have started research programs and clinical activities. However, access to remains limited given that only a few hundred transplants been described worldwide compared 1.5 million childbearing age who suffer from The aim this study was investigate how perceived by Mayer–Rokitansky–Küster–Hauser syndrome health professionals...
Abstract Introduction Graft optimization is a necessity in order to develop uterus transplantation from brain‐dead donors, as complement living these grafts are rare and the last organs retrieved multiple organ donation. The aim of this study was assess feasibility interest hypothermic machine perfusion (HMP) using porcine model; secondary outcomes were evaluation graft's tolerance prolonged cold ischaemia time find new biomarkers viability. Material Methods Fifteen allotransplantations...
Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those most effective component in mixture has not been studied directly human tissues. Suppression synthesis fetal life associated with testis maldescent, malformations genitalia at birth, and poor semen quality later life.Our aim was investigate whether can disrupt production explants evaluate importance when characterizing hazard individual...
Abstract Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless this, it remains unknown whether could act as an endocrine disruptor reported for fellow analgesics paracetamol and aspirin. To investigate we exposed human fetal testes (7–17 gestational weeks (GW)) using ex vivo culture xenograft systems. Ibuprofen suppressed testosterone Leydig cell hormone INSL3 during 8–9 GW concomitant reduction in expression...
Few studies have been undertaken to assess the possible effects of bisphenol A (BPA) on reproductive hormone balance in animals or humans with often contradictory results. We investigated direct endocrine disruption by BPA fetal testes 2 rat strains (14.5-17.5 days post-coitum) and (8-12 gestational weeks) under different culture conditions. concentrations 10(-8)M 10(-5)M for 72 h reduced testosterone production Sprague-Dawley testes, while only 10-5M suppressed it Wistar strain. The...
Abstract In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, angiogenesis. However, the factors conferring inflammatory protumor properties on human remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed impact of monocyte differentiation. report that prolonged lactic acidosis induces differentiation monocytes into with a phenotype including...
The purpose of this study was to develop a nomogram predict 'poor prognosis recurrence' (PPR) in women treated for endometrial cancer (EC). data 861 who received primary surgical treatment between January 2001 and December 2013 were abstracted from prospective multicenter database. Data randomly split into two sets: training validation with predefined 2/3 ratio. A Cox proportional hazards multivariate model selected prognostic features performed the cohort (n=574) predicting PPRs. validated...
Unconventional T cells are defined by their capacity to respond signals other than the well-known complex of peptides and major histocompatibility proteins. Among burgeoning family unconventional cells, innate-like CD8(+) in mouse were discovered early 2000s. This subset bears a memory phenotype without having encountered foreign antigen can IL-12 + IL-18 stimulation. Although concept innate is now well established mice, whether an equivalent NK-like T-cell population exists humans remains...