A5066052362- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- HER2/EGFR in Cancer Research
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Retinal Development and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Eosinophilic Esophagitis
- Lymphoma Diagnosis and Treatment
- Cellular transport and secretion
- Chemical Synthesis and Analysis
- Immune responses and vaccinations
- Multiple Myeloma Research and Treatments
- Prostate Cancer Treatment and Research
- Inflammasome and immune disorders
- Neuropeptides and Animal Physiology
- Trace Elements in Health
- Chemokine receptors and signaling
- Cytomegalovirus and herpesvirus research
- Natural product bioactivities and synthesis
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
Inserm
2011-2024
Centre Hospitalier Universitaire de Poitiers
2017-2024
Université de Poitiers
2014-2024
Ischémie Reperfusion, Métabolisme et Inflammation Stérile en Transplantation
2023-2024
Polymères, Biopolymères, Surfaces
2014-2017
Université de Sherbrooke
2012
Unit of Virus Host Cell Interactions
2011
Unconventional T cells are defined by their capacity to respond signals other than the well-known complex of peptides and major histocompatibility proteins. Among burgeoning family unconventional cells, innate-like CD8(+) in mouse were discovered early 2000s. This subset bears a memory phenotype without having encountered foreign antigen can IL-12 + IL-18 stimulation. Although concept innate is now well established mice, whether an equivalent NK-like T-cell population exists humans remains...
An endoproteolytic cleavage termed α-cleavage between residues 111/112 is a characteristic feature of the cellular prion protein (PrP C ). This generates soluble N-terminal fragment (PrPN1) and glycosylphosphatidylinositol-anchored C-terminal (PrPC1). Independent studies demonstrate that modulating PrP represents potential therapeutic strategy in diseases. The regulation unclear. only known domain essential for to occur hydrophobic (HD). Importantly, HD also formation homodimers. To explore...
Immunological mechanisms of treatment-free remission (TFR) in chronic myeloid leukaemia (CML) are poorly defined and, to date, no correlation between successful TFR and CD8(+) T-cell subsets has been found. We analysed a new identified human subset T-cells, namely innate CML patients with ≥ 2 years. demonstrated dramatic increase functionally active T-cells these as compared control subjects under tyrosine kinase inhibitors. Moreover, we found positive frequencies natural killer cells,...
The switch of human melanoma cell phenotype from non to highly tumorigenic and metastatic is triggered by the increase procathepsin L secretion, which modifies tumour microenvironment. aim present study was identify components involved in regulation secretion cells. We focused on Rab family members, i.e. Rab3A, Rab4A, Rab4B, Rab5A, Rab8A, Rab11A, Rab27A Rab33A, are distinct regulatory pathways. From analysis mRNA protein expression these their knockdown specific siRNAs (small interfering...
We recently identified a new human subset of NK-like [KIR/NKG2A(+)] CD8(+) T cells with marked/memory phenotype, high Eomesodermin expression, potent antigen-independent cytotoxic activity, and the capacity to generate IFN-γ rapidly after exposure pro-inflammatory cytokines. These features support hypothesis that this member innate cell family in humans, hereafter referred as cells, has role cancer immune surveillance analogous invariant natural killer (iNKT) cells. Here, we report first...
Immunosenescence is a physiological process that associated with changes in the immune system, particularly among CD8 T-cells. Recent studies have hypothesized senescent T-cells are produced chronologic age by chronic stimulation, leading to acquisition of hallmarks innate-like While conventional quite well characterized, sharing features NK cells and memory T-cells, newly described cell population. They can be distinguished from their combined expression panKIR/NKG2A Eomesodermin (E),...
High-risk human papillomavirus oncoproteins E6 and E7 play a major role in HPV-related cancers. One of the main functions is degradation pRb, while promotes p53, inactivating p14ARF-p53 pathway. pRb p14ARF can repress ribosomal DNA (rDNA) transcription part by targeting Upstream Binding Factor 1 (UBF1), key factor activation RNA polymerase I machinery. We showed, through ectopic expression siRNA silencing and/or E7, that stimulates UBF1-mediated rDNA gene transcription, partly because...
Over the past thirty years, complexity of αβ-T cell compartment has been enriched by identification innate-like T cells (ITCs), which are composed mainly invariant natural killer (iNKT) and mucosal-associated (MAIT) cells. Based on animal studies using ischemia-reperfusion (IR) models, a key role attributed to iNKT in close connection with alarmin/cytokine interleukin (IL)-33, as early sensors cell-stress initiation acute sterile inflammation. Here we have investigated whether new concept...
Abstract Kinase inhibitors hold great potential as targeted therapy against malignant cells. Among them, the tyrosine kinase inhibitor dasatinib is known for a number of clinically relevant off-target actions, attributed in part to effects on components immune system, especially conventional T-cells and natural killer (NK)-cells. Here, we have hypothesized that also influences non-conventional T-αβ cell subsets their anti-tumoral properties, namely iNKT cells distinct new innate CD8 T-cell...
The EGF-family of tyrosine-kinase receptors activates cytoplasmic pathways involved in cell proliferation, migration and differentiation response to specific extracellular ligands. Beside these canonical pathways, the nuclear localization ErbB primary tumours cancer lines led investigate their role as transcriptional regulators genes. ErbB3 has been reported various tissues but functions putative correlation with tumour progression resistance therapy remain unclear. We first assessed...
Considering the general view that unconventional immune effectors play a major role in antitumor immunity, we recently postulated distinct new innate CD8 T-cell pool (co-expressing transcription factor Eomesodermin and markers such as KIR/NKG2A) may counteract tumor cells, thereby be potential target for cancer therapy. Here, to test this assumption, used successfully targeted anti-leukemic therapy discontinuation (TFR) chronic myeloid leukemia (CML). Numerical functional status of T-cells,...
Abstract Starting with our recent identification in healthy individuals of a new distinct CD8+ T cell subset harboring Eomes and exhibiting marked “innate” (panKIR/NKG2A+) phenotype, we present here the first report on this unique population physiopathological context, namely chronic myelogenous leukemia (CML), clonal myeloproliferative disorder. The current first-line therapies for hematopoietic malignancy are tyrosine kinase inhibitors such as Imatinib (IM). Knowing that generation innate...
come from teaching and research institutions in France or abroad, public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.
Abstract Among the burgeoning family of unconventional T cells, innate-like CD8(+) cells bear a memory phenotype without having encountered foreign antigen and can respond to IL-12+IL-18 stimulation. Although concept innate (IM) is now well-established in mice, whether an equivalent NK-like T-cell population exists humans remains under debate. We recently reported that responding stimulation co-expressing transcription factor Eomesodermin (Eomes) KIR/NKG2A membrane receptors with memory/EMRA...